Peptides derived from the bifunctional kinase/RNase enzyme IRE1α modulate IRE1α activity and protect cells from endoplasmic reticulum stress

ABSTRACT Activation of the bifunctional kinase/RNase enzyme IRE1α is part of an adaptive response triggered on accumulation of misfolded proteins in the endoplasmic reticulum (ER). To facilitate recovery of ER homeostasis, IRE1α molecules oligomerize, allowing for their transautophosphorylation and...

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Veröffentlicht in:	The FASEB journal 2011-09, Vol.25 (9), p.3115-3129
Hauptverfasser:	Bouchecareilh, Marion, Higa, Arisa, Fribourg, Sébastien, Moenner, Michel, Chevet, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	alphascreen Animals Caenorhabditis elegans Cell Line, Tumor DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Endoplasmic Reticulum - metabolism Endoribonucleases - genetics Endoribonucleases - metabolism Gene Expression Regulation Humans MAP Kinase Kinase 4 - genetics MAP Kinase Kinase 4 - metabolism Models, Molecular Peptides Protein Conformation Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Regulatory Factor X Transcription Factors RIDD RNA, Messenger - genetics RNA, Messenger - metabolism Signal Transduction Stress, Physiological Transcription Factors - genetics Transcription Factors - metabolism UPR X-Box Binding Protein 1
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