Diosgenin from Dioscorea nipponica Ameliorates Diabetic Neuropathy by Inducing Nerve Growth Factor

Diabetic neuropathy is characterized by axonal degeneration, demyelination, and atrophy in association with failed axonal regeneration, remyelination, and synaptogenesis. Recent reports suggest that reduced levels of nerve growth factor (NGF) may play a significant role in the pathogenesis of diabet...

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Veröffentlicht in:	Biological & Pharmaceutical Bulletin 2011/09/01, Vol.34(9), pp.1493-1498
Hauptverfasser:	Kang, Tong Ho, Moon, Eunjung, Hong, Bin Na, Choi, Sang Zin, Son, Miwon, Park, Ji-Ho, Kim, Sun Yeou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Atrophy Axonogenesis Axons Cell Line, Tumor Chromatography, High Pressure Liquid Data processing Demyelination Diabetes mellitus Diabetic Neuropathies - physiopathology Diabetic Neuropathies - prevention & control diabetic neuropathy Dioscorea Dioscorea - chemistry diosgenin Diosgenin - analysis Diosgenin - therapeutic use Enzyme-Linked Immunosorbent Assay Mice Microscopes Myelin Nerve conduction nerve conductivity Nerve growth factor Nerve Growth Factor - biosynthesis neurite outgrowth Neuropathy PC12 Cells Pheochromocytoma cells Polyneuropathy Rats Regeneration sapogenins Sciatic nerve Sciatic Nerve - physiopathology Steroid hormones Synaptogenesis
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