Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: A multicenter, retrospective analysis in Japan
We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI–FL. Of the 125 patients, the small intestine was examined in 70 patients, with d...
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| Veröffentlicht in: | Cancer science 2011-08, Vol.102 (8), p.1532-1536 |
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| creator | Takata, Katsuyoshi Okada, Hiroyuki Ohmiya, Naoki Nakamura, Shotaro Kitadai, Yasuhiko Tari, Akira Akamatsu, Taiji Kawai, Hiroki Tanaka, Shu Araki, Hiroshi Yoshida, Takashi Okumura, Hirokazu Nishisaki, Hogara Sagawa, Tamotsu Watanabe, Norihiko Arima, Nobuyoshi Takatsu, Noritaka Nakamura, Masanao Yanai, Shunichi Kaya, Hiroyasu Morito, Toshiaki Sato, Yasuharu Moriwaki, Hisataka Sakamoto, Choitsu Niwa, Yasumasa Goto, Hidemi Chiba, Tsutomu Matsumoto, Takayuki Ennishi, Daisuke Kinoshita, Tomohiro Yoshino, Tadashi |
| description | We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI–FL. Of the 125 patients, the small intestine was examined in 70 patients, with double‐balloon endoscopy and/or capsule endoscopy. The most frequently involved GI–FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP‐positive group. During a median follow up of 40 months, six patients showed disease progression. Patients with involvement of the DSP had better progression‐free survival (PFS) than those without such involvement (P = 0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI–FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course. (Cancer Sci 2011; 102: 1532–1536) |
| doi_str_mv | 10.1111/j.1349-7006.2011.01980.x |
| format | Article |
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This study included 125 patients with stage I and II1 GI–FL. Of the 125 patients, the small intestine was examined in 70 patients, with double‐balloon endoscopy and/or capsule endoscopy. The most frequently involved GI–FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP‐positive group. During a median follow up of 40 months, six patients showed disease progression. Patients with involvement of the DSP had better progression‐free survival (PFS) than those without such involvement (P = 0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI–FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course. (Cancer Sci 2011; 102: 1532–1536)</description><identifier>ISSN: 1347-9032</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2011.01980.x</identifier><identifier>PMID: 21561531</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Disease-Free Survival ; Duodenum - pathology ; Female ; Gastrointestinal Neoplasms - mortality ; Gastrointestinal Neoplasms - pathology ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphoma, Follicular - mortality ; Lymphoma, Follicular - pathology ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Prognosis ; Retrospective Studies ; Tumors</subject><ispartof>Cancer science, 2011-08, Vol.102 (8), p.1532-1536</ispartof><rights>2011 Japanese Cancer Association</rights><rights>2015 INIST-CNRS</rights><rights>2011 Japanese Cancer Association.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5670-89170c57119105502375c4022f0971c256ca8d9919333c46c679b1260953d9293</citedby><cites>FETCH-LOGICAL-c5670-89170c57119105502375c4022f0971c256ca8d9919333c46c679b1260953d9293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1349-7006.2011.01980.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1349-7006.2011.01980.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,11541,27901,27902,45550,45551,46027,46451</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2011.01980.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24465976$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21561531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takata, Katsuyoshi</creatorcontrib><creatorcontrib>Okada, Hiroyuki</creatorcontrib><creatorcontrib>Ohmiya, Naoki</creatorcontrib><creatorcontrib>Nakamura, Shotaro</creatorcontrib><creatorcontrib>Kitadai, Yasuhiko</creatorcontrib><creatorcontrib>Tari, Akira</creatorcontrib><creatorcontrib>Akamatsu, Taiji</creatorcontrib><creatorcontrib>Kawai, Hiroki</creatorcontrib><creatorcontrib>Tanaka, Shu</creatorcontrib><creatorcontrib>Araki, Hiroshi</creatorcontrib><creatorcontrib>Yoshida, Takashi</creatorcontrib><creatorcontrib>Okumura, Hirokazu</creatorcontrib><creatorcontrib>Nishisaki, Hogara</creatorcontrib><creatorcontrib>Sagawa, Tamotsu</creatorcontrib><creatorcontrib>Watanabe, Norihiko</creatorcontrib><creatorcontrib>Arima, Nobuyoshi</creatorcontrib><creatorcontrib>Takatsu, Noritaka</creatorcontrib><creatorcontrib>Nakamura, Masanao</creatorcontrib><creatorcontrib>Yanai, Shunichi</creatorcontrib><creatorcontrib>Kaya, Hiroyasu</creatorcontrib><creatorcontrib>Morito, Toshiaki</creatorcontrib><creatorcontrib>Sato, Yasuharu</creatorcontrib><creatorcontrib>Moriwaki, Hisataka</creatorcontrib><creatorcontrib>Sakamoto, Choitsu</creatorcontrib><creatorcontrib>Niwa, Yasumasa</creatorcontrib><creatorcontrib>Goto, Hidemi</creatorcontrib><creatorcontrib>Chiba, Tsutomu</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>Ennishi, Daisuke</creatorcontrib><creatorcontrib>Kinoshita, Tomohiro</creatorcontrib><creatorcontrib>Yoshino, Tadashi</creatorcontrib><title>Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: A multicenter, retrospective analysis in Japan</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI–FL. Of the 125 patients, the small intestine was examined in 70 patients, with double‐balloon endoscopy and/or capsule endoscopy. The most frequently involved GI–FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP‐positive group. During a median follow up of 40 months, six patients showed disease progression. Patients with involvement of the DSP had better progression‐free survival (PFS) than those without such involvement (P = 0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI–FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course. (Cancer Sci 2011; 102: 1532–1536)</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Disease-Free Survival</subject><subject>Duodenum - pathology</subject><subject>Female</subject><subject>Gastrointestinal Neoplasms - mortality</subject><subject>Gastrointestinal Neoplasms - pathology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphoma, Follicular - mortality</subject><subject>Lymphoma, Follicular - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Tumors</subject><issn>1347-9032</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1v1DAQhiMEoqXwF5AviAtJ_RHbMRKH1YqPVpVAAs6W6zitV44dbGdpfgl_F6e7LVd88Yz8zDvjeasKINigcs53DSKtqDmErMEQoQYi0cHm7kl1-vjw9D7mtYAEn1QvUtpBSFgr2ufVCUaUIUrQafXnW7Sjigu4USnHYH02KVuvHBiCc1bPTkXglnG6DaMC1u-D21t_A_KtAf0cerOiyejgezCFmG3wwCagQG9XHZ2B8dnm5T3YgHF22eqSm_gORFPapcnobPcGqCKzpFJoPbhUk_Ivq2eDcsm8Ot5n1c9PH39sv9RXXz9fbDdXtaaMw7oTiENNOUICQUohJpzqFmI8QMGRxpRp1fVCIEEI0S3TjItrhBkUlPQCC3JWvT3oTjH8msvf5WiTNs4pb8KcZNdxCjlmrJDdgdRl7hTNIKfD6iSCcnVF7uS6fLkuX66uyHtX5F0pfX1sMl-Ppn8sfLChAG-OgEpauSEqr236x7Uto4KvM3w4cL-tM8t_DyC3m-9rRP4ClQSpsg</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Takata, Katsuyoshi</creator><creator>Okada, Hiroyuki</creator><creator>Ohmiya, Naoki</creator><creator>Nakamura, Shotaro</creator><creator>Kitadai, Yasuhiko</creator><creator>Tari, Akira</creator><creator>Akamatsu, Taiji</creator><creator>Kawai, Hiroki</creator><creator>Tanaka, Shu</creator><creator>Araki, Hiroshi</creator><creator>Yoshida, Takashi</creator><creator>Okumura, Hirokazu</creator><creator>Nishisaki, Hogara</creator><creator>Sagawa, Tamotsu</creator><creator>Watanabe, Norihiko</creator><creator>Arima, Nobuyoshi</creator><creator>Takatsu, Noritaka</creator><creator>Nakamura, Masanao</creator><creator>Yanai, Shunichi</creator><creator>Kaya, Hiroyasu</creator><creator>Morito, Toshiaki</creator><creator>Sato, Yasuharu</creator><creator>Moriwaki, Hisataka</creator><creator>Sakamoto, Choitsu</creator><creator>Niwa, Yasumasa</creator><creator>Goto, Hidemi</creator><creator>Chiba, Tsutomu</creator><creator>Matsumoto, Takayuki</creator><creator>Ennishi, Daisuke</creator><creator>Kinoshita, Tomohiro</creator><creator>Yoshino, Tadashi</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: A multicenter, retrospective analysis in Japan</title><author>Takata, Katsuyoshi ; Okada, Hiroyuki ; Ohmiya, Naoki ; Nakamura, Shotaro ; Kitadai, Yasuhiko ; Tari, Akira ; Akamatsu, Taiji ; Kawai, Hiroki ; Tanaka, Shu ; Araki, Hiroshi ; Yoshida, Takashi ; Okumura, Hirokazu ; Nishisaki, Hogara ; Sagawa, Tamotsu ; Watanabe, Norihiko ; Arima, Nobuyoshi ; Takatsu, Noritaka ; Nakamura, Masanao ; Yanai, Shunichi ; Kaya, Hiroyasu ; Morito, Toshiaki ; Sato, Yasuharu ; Moriwaki, Hisataka ; Sakamoto, Choitsu ; Niwa, Yasumasa ; Goto, Hidemi ; Chiba, Tsutomu ; Matsumoto, Takayuki ; Ennishi, Daisuke ; Kinoshita, Tomohiro ; Yoshino, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5670-89170c57119105502375c4022f0971c256ca8d9919333c46c679b1260953d9293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Disease-Free Survival</topic><topic>Duodenum - pathology</topic><topic>Female</topic><topic>Gastrointestinal Neoplasms - mortality</topic><topic>Gastrointestinal Neoplasms - pathology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphoma, Follicular - mortality</topic><topic>Lymphoma, Follicular - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takata, Katsuyoshi</creatorcontrib><creatorcontrib>Okada, Hiroyuki</creatorcontrib><creatorcontrib>Ohmiya, Naoki</creatorcontrib><creatorcontrib>Nakamura, Shotaro</creatorcontrib><creatorcontrib>Kitadai, Yasuhiko</creatorcontrib><creatorcontrib>Tari, Akira</creatorcontrib><creatorcontrib>Akamatsu, Taiji</creatorcontrib><creatorcontrib>Kawai, Hiroki</creatorcontrib><creatorcontrib>Tanaka, Shu</creatorcontrib><creatorcontrib>Araki, Hiroshi</creatorcontrib><creatorcontrib>Yoshida, Takashi</creatorcontrib><creatorcontrib>Okumura, Hirokazu</creatorcontrib><creatorcontrib>Nishisaki, Hogara</creatorcontrib><creatorcontrib>Sagawa, Tamotsu</creatorcontrib><creatorcontrib>Watanabe, Norihiko</creatorcontrib><creatorcontrib>Arima, Nobuyoshi</creatorcontrib><creatorcontrib>Takatsu, Noritaka</creatorcontrib><creatorcontrib>Nakamura, Masanao</creatorcontrib><creatorcontrib>Yanai, Shunichi</creatorcontrib><creatorcontrib>Kaya, Hiroyasu</creatorcontrib><creatorcontrib>Morito, Toshiaki</creatorcontrib><creatorcontrib>Sato, Yasuharu</creatorcontrib><creatorcontrib>Moriwaki, Hisataka</creatorcontrib><creatorcontrib>Sakamoto, Choitsu</creatorcontrib><creatorcontrib>Niwa, Yasumasa</creatorcontrib><creatorcontrib>Goto, Hidemi</creatorcontrib><creatorcontrib>Chiba, Tsutomu</creatorcontrib><creatorcontrib>Matsumoto, Takayuki</creatorcontrib><creatorcontrib>Ennishi, Daisuke</creatorcontrib><creatorcontrib>Kinoshita, Tomohiro</creatorcontrib><creatorcontrib>Yoshino, Tadashi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Takata, Katsuyoshi</au><au>Okada, Hiroyuki</au><au>Ohmiya, Naoki</au><au>Nakamura, Shotaro</au><au>Kitadai, Yasuhiko</au><au>Tari, Akira</au><au>Akamatsu, Taiji</au><au>Kawai, Hiroki</au><au>Tanaka, Shu</au><au>Araki, Hiroshi</au><au>Yoshida, Takashi</au><au>Okumura, Hirokazu</au><au>Nishisaki, Hogara</au><au>Sagawa, Tamotsu</au><au>Watanabe, Norihiko</au><au>Arima, Nobuyoshi</au><au>Takatsu, Noritaka</au><au>Nakamura, Masanao</au><au>Yanai, Shunichi</au><au>Kaya, Hiroyasu</au><au>Morito, Toshiaki</au><au>Sato, Yasuharu</au><au>Moriwaki, Hisataka</au><au>Sakamoto, Choitsu</au><au>Niwa, Yasumasa</au><au>Goto, Hidemi</au><au>Chiba, Tsutomu</au><au>Matsumoto, Takayuki</au><au>Ennishi, Daisuke</au><au>Kinoshita, Tomohiro</au><au>Yoshino, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: A multicenter, retrospective analysis in Japan</atitle><jtitle>Cancer science</jtitle><addtitle>Cancer Sci</addtitle><date>2011-08</date><risdate>2011</risdate><volume>102</volume><issue>8</issue><spage>1532</spage><epage>1536</epage><pages>1532-1536</pages><issn>1347-9032</issn><eissn>1349-7006</eissn><abstract>We conducted a multicenter, retrospective study to determine the anatomical distribution and prognostic factors of gastrointestinal (GI) follicular lymphoma (FL). This study included 125 patients with stage I and II1 GI–FL. Of the 125 patients, the small intestine was examined in 70 patients, with double‐balloon endoscopy and/or capsule endoscopy. The most frequently involved GI–FL site was the duodenal second portion (DSP) (81%), followed by the jejunum (40%); 85% of patients with involvement of the DSP also had jejunal or ileal lesions. The absence of abdominal symptoms and macroscopic appearance of multiple nodules were significantly present in the DSP‐positive group. During a median follow up of 40 months, six patients showed disease progression. Patients with involvement of the DSP had better progression‐free survival (PFS) than those without such involvement (P = 0.001). A multivariate analysis revealed that male sex, the presence of abdominal symptoms, and negative involvement of the DSP were independently associated with poor PFS. In conclusion, most patients with GI–FL have duodenal lesions associated with multiple jejunal or ileal lesions. Gastrointestinal follicular lymphomas involving the DSP might be a distinct entity showing a favorable clinical course. (Cancer Sci 2011; 102: 1532–1536)</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>21561531</pmid><doi>10.1111/j.1349-7006.2011.01980.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences Disease-Free Survival Duodenum - pathology Female Gastrointestinal Neoplasms - mortality Gastrointestinal Neoplasms - pathology Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Follicular - mortality Lymphoma, Follicular - pathology Male Medical sciences Middle Aged Multivariate Analysis Prognosis Retrospective Studies Tumors |
| title | Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: A multicenter, retrospective analysis in Japan |
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