Second-Generation Total Synthesis of Spirastrellolide F Methyl Ester: The Alkyne Route

Outlandish: The spiroketal embedded in spirastrellolide F methyl ester is a daring site for ring closure, yet it has allowed the power of catalytic alkyne scission and activation to be showcased (see scheme). An improved strategy for the introduction of the labile side chain was also developed.

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Bibliographische Detailangaben
Veröffentlicht in:	Angewandte Chemie International Edition 2011-09, Vol.50 (37), p.8739-8744
Hauptverfasser:	Benson, Stefan, Collin, Marie-Pierre, Arlt, Alexander, Gabor, Barbara, Goddard, Richard, Fürstner, Alois
Format:	Artikel
Sprache:	eng
Schlagworte:	alkyne metathesis Alkynes - chemistry Crystallography, X-Ray gold Macrolides - chemical synthesis Macrolides - chemistry Models, Molecular Molecular Conformation molybdenum natural products Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Stereoisomerism total synthesis
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Beschreibung
Zusammenfassung:	Outlandish: The spiroketal embedded in spirastrellolide F methyl ester is a daring site for ring closure, yet it has allowed the power of catalytic alkyne scission and activation to be showcased (see scheme). An improved strategy for the introduction of the labile side chain was also developed.
ISSN:	1433-7851 1521-3773
DOI:	10.1002/anie.201103270