Impact of endogenous luteinizing hormone serum levels on progesterone elevation on the day of human chorionic gonadotropin administration
Objective To assess the relationship between endogenous LH serum levels after GnRH analogue administration and serum P elevation on the day of hCG administration (P hCG). Design Retrospective study. Setting Reproductive medicine center in a university hospital. Patient(s) A total of 708 patients und...
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| Veröffentlicht in: | Fertility and sterility 2011-09, Vol.96 (3), p.600-604 |
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| creator | Hugues, Jean-noêl, M.D., Ph.D Massé-Laroche, Emmanuelle, M.D Reboul-Marty, Jeanne, M.D Boîko, Oksana, M.D Meynant, Céline, M.D Cédrin-Durnerin, Isabelle, M.D |
| description | Objective To assess the relationship between endogenous LH serum levels after GnRH analogue administration and serum P elevation on the day of hCG administration (P hCG). Design Retrospective study. Setting Reproductive medicine center in a university hospital. Patient(s) A total of 708 patients undergoing a GnRH agonist or antagonist protocol for IVF intracytoplasmic sperm injection. Intervention(s) Controlled ovarian stimulation. Main Outcome Measure(s) Serum P values according to GnRH analogue; correlation between serum LH measurements and P hCG values. Result(s) Serum P hCG values were significantly lower following the GnRH antagonist than agonist protocol. A positive correlation between serum P hCG and LH area under the curve or day 6 LH values was found in the GnRH agonist group and between P hCG and LH hCG levels in both GnRH analogue regimens. With multivariate analysis, P hCG values were positively correlated with serum E2 levels on hCG administration day and with the total FSH dose in both GnRH analogue–treated groups. Additionally, the correlation between serum P hCG and LH hCG values was positive in patients treated with the GnRH agonist protocol. Conclusion(s) The lower serum P levels on hCG administration day following the GnRH antagonist protocol are mainly explained by lower granulosa cell steroidogenic activity. The correlation with serum LH hCG values was positive in the GnRH agonist–treated group. |
| doi_str_mv | 10.1016/j.fertnstert.2011.06.061 |
| format | Article |
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Design Retrospective study. Setting Reproductive medicine center in a university hospital. Patient(s) A total of 708 patients undergoing a GnRH agonist or antagonist protocol for IVF intracytoplasmic sperm injection. Intervention(s) Controlled ovarian stimulation. Main Outcome Measure(s) Serum P values according to GnRH analogue; correlation between serum LH measurements and P hCG values. Result(s) Serum P hCG values were significantly lower following the GnRH antagonist than agonist protocol. A positive correlation between serum P hCG and LH area under the curve or day 6 LH values was found in the GnRH agonist group and between P hCG and LH hCG levels in both GnRH analogue regimens. With multivariate analysis, P hCG values were positively correlated with serum E2 levels on hCG administration day and with the total FSH dose in both GnRH analogue–treated groups. Additionally, the correlation between serum P hCG and LH hCG values was positive in patients treated with the GnRH agonist protocol. Conclusion(s) The lower serum P levels on hCG administration day following the GnRH antagonist protocol are mainly explained by lower granulosa cell steroidogenic activity. The correlation with serum LH hCG values was positive in the GnRH agonist–treated group.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2011.06.061</identifier><identifier>PMID: 21880277</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Biological and medical sciences ; blood serum ; Chorionic Gonadotropin - administration & dosage ; controlled ovarian stimulation ; endogenous LH ; Female ; GnRH agonist ; GnRH antagonist ; Gonadotropin-Releasing Hormone - agonists ; Gonadotropin-Releasing Hormone - antagonists & inhibitors ; Granulosa Cells - drug effects ; Granulosa Cells - physiology ; Gynecology. Andrology. Obstetrics ; hormone agonists ; hormone antagonists ; human chorionic gonadotropin ; Humans ; Infertility, Female - drug therapy ; Internal Medicine ; intracytoplasmic sperm injection ; luteinizing hormone ; Luteinizing Hormone - blood ; Medical sciences ; Multivariate Analysis ; Obstetrics and Gynecology ; Ovulation Induction - methods ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Progesterone ; Progesterone - blood ; Retrospective Studies ; Sperm Injections, Intracytoplasmic - methods</subject><ispartof>Fertility and sterility, 2011-09, Vol.96 (3), p.600-604</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2011 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-8ad84a767d1b57bce65feb14198bfde841e50107eaa4b185a0a82212a12201273</citedby><cites>FETCH-LOGICAL-c482t-8ad84a767d1b57bce65feb14198bfde841e50107eaa4b185a0a82212a12201273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2011.06.061$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24533169$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21880277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hugues, Jean-noêl, M.D., Ph.D</creatorcontrib><creatorcontrib>Massé-Laroche, Emmanuelle, M.D</creatorcontrib><creatorcontrib>Reboul-Marty, Jeanne, M.D</creatorcontrib><creatorcontrib>Boîko, Oksana, M.D</creatorcontrib><creatorcontrib>Meynant, Céline, M.D</creatorcontrib><creatorcontrib>Cédrin-Durnerin, Isabelle, M.D</creatorcontrib><title>Impact of endogenous luteinizing hormone serum levels on progesterone elevation on the day of human chorionic gonadotropin administration</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To assess the relationship between endogenous LH serum levels after GnRH analogue administration and serum P elevation on the day of hCG administration (P hCG). Design Retrospective study. Setting Reproductive medicine center in a university hospital. Patient(s) A total of 708 patients undergoing a GnRH agonist or antagonist protocol for IVF intracytoplasmic sperm injection. Intervention(s) Controlled ovarian stimulation. Main Outcome Measure(s) Serum P values according to GnRH analogue; correlation between serum LH measurements and P hCG values. Result(s) Serum P hCG values were significantly lower following the GnRH antagonist than agonist protocol. A positive correlation between serum P hCG and LH area under the curve or day 6 LH values was found in the GnRH agonist group and between P hCG and LH hCG levels in both GnRH analogue regimens. With multivariate analysis, P hCG values were positively correlated with serum E2 levels on hCG administration day and with the total FSH dose in both GnRH analogue–treated groups. Additionally, the correlation between serum P hCG and LH hCG values was positive in patients treated with the GnRH agonist protocol. Conclusion(s) The lower serum P levels on hCG administration day following the GnRH antagonist protocol are mainly explained by lower granulosa cell steroidogenic activity. The correlation with serum LH hCG values was positive in the GnRH agonist–treated group.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>blood serum</subject><subject>Chorionic Gonadotropin - administration & dosage</subject><subject>controlled ovarian stimulation</subject><subject>endogenous LH</subject><subject>Female</subject><subject>GnRH agonist</subject><subject>GnRH antagonist</subject><subject>Gonadotropin-Releasing Hormone - agonists</subject><subject>Gonadotropin-Releasing Hormone - antagonists & inhibitors</subject><subject>Granulosa Cells - drug effects</subject><subject>Granulosa Cells - physiology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>hormone agonists</subject><subject>hormone antagonists</subject><subject>human chorionic gonadotropin</subject><subject>Humans</subject><subject>Infertility, Female - drug therapy</subject><subject>Internal Medicine</subject><subject>intracytoplasmic sperm injection</subject><subject>luteinizing hormone</subject><subject>Luteinizing Hormone - blood</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Obstetrics and Gynecology</subject><subject>Ovulation Induction - methods</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Rate</subject><subject>Progesterone</subject><subject>Progesterone - blood</subject><subject>Retrospective Studies</subject><subject>Sperm Injections, Intracytoplasmic - methods</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNks-O0zAQxi0EYkvhFcAXxKnF48SJe0FiV_xZaSUOy54tx5m0Lold7GSl8ga8NRNaWIkT0siW7N98M-PPjHEQaxBQvd2vO0xjyCOtaykA1qKigEdsAUpVK1Wp4jFbCAFqJaSWF-xZznshCKnlU3YhQWsh63rBfl4PB-tGHjuOoY1bDHHKvJ9G9MH_8GHLdzENMSDPmKaB93iPfeYx8EMieu5gvkQ6t6OnY4pxh7y1x1lzNw02cEcadOcd38Zg2zimePCB23agInlMvzOfsyed7TO-OO9Ldvfxw9erz6ubL5-ur97frFyp5bjSttWlrau6hUbVjcNKddhACRvddC3qElAJEDVaWzaglRVWSwnSgqSHknWxZG9OujTA94kmMIPPDvveBqTZjda1EmojBJH6RLoUc07YmUPyg01HA8LMPpi9efDBzD4YUVEApb48F5maAdu_iX8enoDXZ8BmZ_su2eB8fuBKVRRQbYh7deI6G43dJmLubqmSIm-lFoQt2eWJIF_w3mMy2XkMDluf0I2mjf5_-n33j4jryRvq7BseMe_jlAKZYsBkaYS5nX_W_LGAZEWh6-IXtknNZg</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Hugues, Jean-noêl, M.D., Ph.D</creator><creator>Massé-Laroche, Emmanuelle, M.D</creator><creator>Reboul-Marty, Jeanne, M.D</creator><creator>Boîko, Oksana, M.D</creator><creator>Meynant, Céline, M.D</creator><creator>Cédrin-Durnerin, Isabelle, M.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Impact of endogenous luteinizing hormone serum levels on progesterone elevation on the day of human chorionic gonadotropin administration</title><author>Hugues, Jean-noêl, M.D., Ph.D ; Massé-Laroche, Emmanuelle, M.D ; Reboul-Marty, Jeanne, M.D ; Boîko, Oksana, M.D ; Meynant, Céline, M.D ; Cédrin-Durnerin, Isabelle, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-8ad84a767d1b57bce65feb14198bfde841e50107eaa4b185a0a82212a12201273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>blood serum</topic><topic>Chorionic Gonadotropin - administration & dosage</topic><topic>controlled ovarian stimulation</topic><topic>endogenous LH</topic><topic>Female</topic><topic>GnRH agonist</topic><topic>GnRH antagonist</topic><topic>Gonadotropin-Releasing Hormone - agonists</topic><topic>Gonadotropin-Releasing Hormone - antagonists & inhibitors</topic><topic>Granulosa Cells - drug effects</topic><topic>Granulosa Cells - physiology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>hormone agonists</topic><topic>hormone antagonists</topic><topic>human chorionic gonadotropin</topic><topic>Humans</topic><topic>Infertility, Female - drug therapy</topic><topic>Internal Medicine</topic><topic>intracytoplasmic sperm injection</topic><topic>luteinizing hormone</topic><topic>Luteinizing Hormone - blood</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Obstetrics and Gynecology</topic><topic>Ovulation Induction - methods</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Rate</topic><topic>Progesterone</topic><topic>Progesterone - blood</topic><topic>Retrospective Studies</topic><topic>Sperm Injections, Intracytoplasmic - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hugues, Jean-noêl, M.D., Ph.D</creatorcontrib><creatorcontrib>Massé-Laroche, Emmanuelle, M.D</creatorcontrib><creatorcontrib>Reboul-Marty, Jeanne, M.D</creatorcontrib><creatorcontrib>Boîko, Oksana, M.D</creatorcontrib><creatorcontrib>Meynant, Céline, M.D</creatorcontrib><creatorcontrib>Cédrin-Durnerin, Isabelle, M.D</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hugues, Jean-noêl, M.D., Ph.D</au><au>Massé-Laroche, Emmanuelle, M.D</au><au>Reboul-Marty, Jeanne, M.D</au><au>Boîko, Oksana, M.D</au><au>Meynant, Céline, M.D</au><au>Cédrin-Durnerin, Isabelle, M.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of endogenous luteinizing hormone serum levels on progesterone elevation on the day of human chorionic gonadotropin administration</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>96</volume><issue>3</issue><spage>600</spage><epage>604</epage><pages>600-604</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To assess the relationship between endogenous LH serum levels after GnRH analogue administration and serum P elevation on the day of hCG administration (P hCG). Design Retrospective study. Setting Reproductive medicine center in a university hospital. Patient(s) A total of 708 patients undergoing a GnRH agonist or antagonist protocol for IVF intracytoplasmic sperm injection. Intervention(s) Controlled ovarian stimulation. Main Outcome Measure(s) Serum P values according to GnRH analogue; correlation between serum LH measurements and P hCG values. Result(s) Serum P hCG values were significantly lower following the GnRH antagonist than agonist protocol. A positive correlation between serum P hCG and LH area under the curve or day 6 LH values was found in the GnRH agonist group and between P hCG and LH hCG levels in both GnRH analogue regimens. With multivariate analysis, P hCG values were positively correlated with serum E2 levels on hCG administration day and with the total FSH dose in both GnRH analogue–treated groups. Additionally, the correlation between serum P hCG and LH hCG values was positive in patients treated with the GnRH agonist protocol. Conclusion(s) The lower serum P levels on hCG administration day following the GnRH antagonist protocol are mainly explained by lower granulosa cell steroidogenic activity. The correlation with serum LH hCG values was positive in the GnRH agonist–treated group.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>21880277</pmid><doi>10.1016/j.fertnstert.2011.06.061</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Biological and medical sciences blood serum Chorionic Gonadotropin - administration & dosage controlled ovarian stimulation endogenous LH Female GnRH agonist GnRH antagonist Gonadotropin-Releasing Hormone - agonists Gonadotropin-Releasing Hormone - antagonists & inhibitors Granulosa Cells - drug effects Granulosa Cells - physiology Gynecology. Andrology. Obstetrics hormone agonists hormone antagonists human chorionic gonadotropin Humans Infertility, Female - drug therapy Internal Medicine intracytoplasmic sperm injection luteinizing hormone Luteinizing Hormone - blood Medical sciences Multivariate Analysis Obstetrics and Gynecology Ovulation Induction - methods Pregnancy Pregnancy Outcome Pregnancy Rate Progesterone Progesterone - blood Retrospective Studies Sperm Injections, Intracytoplasmic - methods |
| title | Impact of endogenous luteinizing hormone serum levels on progesterone elevation on the day of human chorionic gonadotropin administration |
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