Coevolution of Morphology and Virulence in Candida Species
Many of the major human fungal pathogens are known to undergo morphological changes, which in certain cases are associated with virulence. Although there has been an intense research focus on morphology in fungi, very little is known about how morphology evolved in conjunction with a variety of othe...
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Veröffentlicht in: | Eukaryotic Cell 2011-09, Vol.10 (9), p.1173-1182 |
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creator | Thompson, Delma S Carlisle, Patricia L Kadosh, David |
description | Many of the major human fungal pathogens are known to undergo morphological changes, which in certain cases are associated with virulence. Although there has been an intense research focus on morphology in fungi, very little is known about how morphology evolved in conjunction with a variety of other virulence properties. However, several recent important discoveries, primarily in Candida species, are beginning to shed light on this important area and answer many longstanding questions. In this minireview, we first provide a description of the major fungal morphologies, as well as the roles of morphology and morphology-associated gene expression in virulence. Next, focusing largely on Candida species, we examine the evolutionary relationships among specific morphological forms. Finally, drawing on recent findings, we begin to address the question of how specific morphological changes came to be associated with virulence of Candida species during evolution. |
doi_str_mv | 10.1128/EC.05085-11 |
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subjects | Candida Candida - cytology Candida - genetics Candida - pathogenicity Candidiasis - microbiology coevolution fungi Fungi - genetics Fungi - pathogenicity Gene Expression Humans Hyphae - cytology Hyphae - genetics Minireviews Models, Biological pathogens Phenotype virulence Virulence - genetics Virulence Factors - genetics Yeasts - cytology Yeasts - genetics |
title | Coevolution of Morphology and Virulence in Candida Species |
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