Characterization of four conventional dendritic cell subsets in human skin-draining lymph nodes in relation to T-cell activation

To increase (tumor) vaccine efficacy, there is an urgent need for phenotypic and functional characterization of human dendritic cell (DC) subsets residing in lymphoid tissues. In this study we identified and functionally tested 4 human conventional DC (cDC) subsets within skin-draining sentinel lymp...

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Veröffentlicht in:	Blood 2011-09, Vol.118 (9), p.2502-2510
Hauptverfasser:	van de Ven, Rieneke, van den Hout, Mari F.C.M., Lindenberg, Jelle J., Sluijter, Berbel J.R., van Leeuwen, Paul A.M., Lougheed, Sinéad M., Meijer, Sybren, van den Tol, M. Petrousjka, Scheper, Rik J., de Gruijl, Tanja D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - analysis Antigens, CD1 - analysis Antigens, Surface - analysis Biological and medical sciences Cadherins - analysis CD11c Antigen - analysis Dendritic Cells - chemistry Dendritic Cells - classification Dendritic Cells - immunology Flow Cytometry Hematologic and hematopoietic diseases Humans Immunophenotyping Integrin alpha Chains - analysis Langerhans Cells - chemistry Langerhans Cells - immunology Lectins, C-Type - analysis Lipopolysaccharide Receptors - analysis Lymph Nodes - cytology Lymph Nodes - immunology Lymphocyte Activation Lymphocyte Culture Test, Mixed Lymphokines - metabolism Mannose-Binding Lectins - analysis Medical sciences Melanoma - immunology Melanoma - pathology Melanoma - surgery Sentinel Lymph Node Biopsy Skin - immunology Skin Neoplasms - immunology Skin Neoplasms - pathology Skin Neoplasms - surgery T-Lymphocytes - immunology
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