NBS1 Recruits RAD18 via a RAD6-like Domain and Regulates Pol η-Dependent Translesion DNA Synthesis

Translesion DNA synthesis, a process orchestrated by monoubiquitinated PCNA, is critical for DNA damage tolerance. While the ubiquitin-conjugating enzyme RAD6 and ubiquitin ligase RAD18 are known to monoubiquitinate PCNA, how they are regulated by DNA damage is not fully understood. We show that NBS...

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Veröffentlicht in:	Molecular cell 2011-09, Vol.43 (5), p.788-797
Hauptverfasser:	Yanagihara, Hiromi, Kobayashi, Junya, Tateishi, Satoshi, Kato, Akihiro, Matsuura, Shinya, Tauchi, Hiroshi, Yamada, Kouichi, Takezawa, Jun, Sugasawa, Kaoru, Masutani, Chikahide, Hanaoka, Fumio, Weemaes, Corry M., Mori, Toshio, Zou, Lee, Komatsu, Kenshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line Cells, Cultured DNA DNA - metabolism DNA Damage DNA Repair DNA Replication - physiology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Humans Mice Mice, Knockout Mutation Nuclear Proteins - genetics Nuclear Proteins - metabolism proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism Ubiquitin-Conjugating Enzymes - genetics Ubiquitin-Conjugating Enzymes - metabolism ubiquitin-protein ligase Ubiquitination ultraviolet radiation Ultraviolet Rays
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