Genetic Contribution of Catechol-O-Methyltransferase Polymorphism (Val158Met) in Children With Chronic Tension-Type Headache
Our aim was to investigate the relationship between Val158Met polymorphisms, headache, and pressure hypersensitivity in children with chronic tension-type headache (CTTH). A case–control study with blinded assessor was conducted. Seventy children with CTTH associated with pericranial tenderness and...
Gespeichert in:
| Veröffentlicht in: | Pediatric research 2011-10, Vol.70 (4), p.395-399 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 399 |
|---|---|
| container_issue | 4 |
| container_start_page | 395 |
| container_title | Pediatric research |
| container_volume | 70 |
| creator | Fernández-de-Las-Peñas, César Ambite-Quesada, Silvia Rivas-Martínez, Inés Ortega-Santiago, Ricardo de-la-Llave-Rincón, Ana Isabel Fernández-Mayoralas, Daniel M Pareja, Juan A |
| description | Our aim was to investigate the relationship between Val158Met polymorphisms, headache, and pressure hypersensitivity in children with chronic tension-type headache (CTTH). A case–control study with blinded assessor was conducted. Seventy children with CTTH associated with pericranial tenderness and 70 healthy children participated. After amplifying Val158Met polymorphism by polymerase chain reactions, we assessed genotype frequencies and allele distributions. We classified children according to their Val158Met polymorphism: Val/Val, Val/Met, Met/Met. Pressure pain thresholds (PPT) were bilaterally assessed over the temporalis, upper trapezius, second metacarpal, and tibialis anterior muscles. The distribution of Val158Met genotypes was not significantly different (
p
= 0.335), between children with CTTH and healthy children, and between boys and girls (
p
= 0.872). Children with CTTH with the Met/Met genotype showed a longer headache history compared with those with Met/Val (
p
= 0.001) or Val/Val (
p
= 0.002) genotype. Children with CTTH with Met/Met genotype showed lower PPT over upper trapezius and temporalis muscles than children with CTTH with Met/Val or Val/Val genotype (
p
< 0.01). The Val158Met catechol-
O
-methyltransferase (COMT) polymorphism does not appear to be involved in predisposition to suffer from CTTH in children; nevertheless, this genetic factor may be involved in the phenotypic expression, as pressure hypersensitivity was greater in those CTTH children with the Met/Met genotype. |
| doi_str_mv | 10.1203/PDR.0b013e318229448a |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_887503147</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>887503147</sourcerecordid><originalsourceid>FETCH-LOGICAL-c428t-d333bde194859de29241cd84302f28d89f93cba00bf5752096180f2120a104d53</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi0EokvhHyDkCwIOKf7s2kcUoK1U1AotcIwce0xcJfbWTg4r9cfX1S5U4sBpNJpn3hk9CL2m5IQywj9ef_5-QnpCOXCqGNNCKPMErajkpCFCrJ-iFSGcNlxrdYRelHJDCBVSiefoiNFTTZlQK3R3BhHmYHGb4pxDv8whRZw8bs0Mdkhjc9V8g3nYjXM2sXjIpgC-TuNuSnk7hDLh9z_NSKWq1AccIm6HMLoMEf8K81C7nGKN30AsNbnZ7LaAz8E4Ywd4iZ55MxZ4dajH6MfXL5v2vLm8OrtoP102VjA1N45z3jugWiipHTDNBLVOCU6YZ8op7TW3vSGk93ItGdGnVBHPqiVDiXCSH6N3-9xtTrcLlLmbQrEwjiZCWkqn1FpWVWJdSbEnbU6lZPDdNofJ5F1HSfegvavau3-117U3hwNLP4H7u_THcwXeHgBTrBl9dWlDeeSElEzxB07uuVJH8Tfk7iYtOVY5_3_gHr3fm9I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>887503147</pqid></control><display><type>article</type><title>Genetic Contribution of Catechol-O-Methyltransferase Polymorphism (Val158Met) in Children With Chronic Tension-Type Headache</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Fernández-de-Las-Peñas, César ; Ambite-Quesada, Silvia ; Rivas-Martínez, Inés ; Ortega-Santiago, Ricardo ; de-la-Llave-Rincón, Ana Isabel ; Fernández-Mayoralas, Daniel M ; Pareja, Juan A</creator><creatorcontrib>Fernández-de-Las-Peñas, César ; Ambite-Quesada, Silvia ; Rivas-Martínez, Inés ; Ortega-Santiago, Ricardo ; de-la-Llave-Rincón, Ana Isabel ; Fernández-Mayoralas, Daniel M ; Pareja, Juan A</creatorcontrib><description>Our aim was to investigate the relationship between Val158Met polymorphisms, headache, and pressure hypersensitivity in children with chronic tension-type headache (CTTH). A case–control study with blinded assessor was conducted. Seventy children with CTTH associated with pericranial tenderness and 70 healthy children participated. After amplifying Val158Met polymorphism by polymerase chain reactions, we assessed genotype frequencies and allele distributions. We classified children according to their Val158Met polymorphism: Val/Val, Val/Met, Met/Met. Pressure pain thresholds (PPT) were bilaterally assessed over the temporalis, upper trapezius, second metacarpal, and tibialis anterior muscles. The distribution of Val158Met genotypes was not significantly different (
p
= 0.335), between children with CTTH and healthy children, and between boys and girls (
p
= 0.872). Children with CTTH with the Met/Met genotype showed a longer headache history compared with those with Met/Val (
p
= 0.001) or Val/Val (
p
= 0.002) genotype. Children with CTTH with Met/Met genotype showed lower PPT over upper trapezius and temporalis muscles than children with CTTH with Met/Val or Val/Val genotype (
p
< 0.01). The Val158Met catechol-
O
-methyltransferase (COMT) polymorphism does not appear to be involved in predisposition to suffer from CTTH in children; nevertheless, this genetic factor may be involved in the phenotypic expression, as pressure hypersensitivity was greater in those CTTH children with the Met/Met genotype.</description><identifier>ISSN: 0031-3998</identifier><identifier>EISSN: 1530-0447</identifier><identifier>DOI: 10.1203/PDR.0b013e318229448a</identifier><identifier>PMID: 21691248</identifier><identifier>CODEN: PEREBL</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/208/2489/144 ; 692/699/375/226 ; 692/700/1720 ; Biological and medical sciences ; Case-Control Studies ; Catechol O-Methyltransferase - genetics ; Child ; clinical-investigation ; Female ; Gene Frequency ; General aspects ; Genotype ; Humans ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Methionine - genetics ; Pain Threshold - physiology ; Pediatric Surgery ; Pediatrics ; Polymorphism, Genetic ; Pressure ; Tension-Type Headache - enzymology ; Tension-Type Headache - genetics ; Tension-Type Headache - physiopathology ; Valine - genetics</subject><ispartof>Pediatric research, 2011-10, Vol.70 (4), p.395-399</ispartof><rights>International Pediatrics Research Foundation, Inc. 2011</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-d333bde194859de29241cd84302f28d89f93cba00bf5752096180f2120a104d53</citedby><cites>FETCH-LOGICAL-c428t-d333bde194859de29241cd84302f28d89f93cba00bf5752096180f2120a104d53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24552838$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21691248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fernández-de-Las-Peñas, César</creatorcontrib><creatorcontrib>Ambite-Quesada, Silvia</creatorcontrib><creatorcontrib>Rivas-Martínez, Inés</creatorcontrib><creatorcontrib>Ortega-Santiago, Ricardo</creatorcontrib><creatorcontrib>de-la-Llave-Rincón, Ana Isabel</creatorcontrib><creatorcontrib>Fernández-Mayoralas, Daniel M</creatorcontrib><creatorcontrib>Pareja, Juan A</creatorcontrib><title>Genetic Contribution of Catechol-O-Methyltransferase Polymorphism (Val158Met) in Children With Chronic Tension-Type Headache</title><title>Pediatric research</title><addtitle>Pediatr Res</addtitle><addtitle>Pediatr Res</addtitle><description>Our aim was to investigate the relationship between Val158Met polymorphisms, headache, and pressure hypersensitivity in children with chronic tension-type headache (CTTH). A case–control study with blinded assessor was conducted. Seventy children with CTTH associated with pericranial tenderness and 70 healthy children participated. After amplifying Val158Met polymorphism by polymerase chain reactions, we assessed genotype frequencies and allele distributions. We classified children according to their Val158Met polymorphism: Val/Val, Val/Met, Met/Met. Pressure pain thresholds (PPT) were bilaterally assessed over the temporalis, upper trapezius, second metacarpal, and tibialis anterior muscles. The distribution of Val158Met genotypes was not significantly different (
p
= 0.335), between children with CTTH and healthy children, and between boys and girls (
p
= 0.872). Children with CTTH with the Met/Met genotype showed a longer headache history compared with those with Met/Val (
p
= 0.001) or Val/Val (
p
= 0.002) genotype. Children with CTTH with Met/Met genotype showed lower PPT over upper trapezius and temporalis muscles than children with CTTH with Met/Val or Val/Val genotype (
p
< 0.01). The Val158Met catechol-
O
-methyltransferase (COMT) polymorphism does not appear to be involved in predisposition to suffer from CTTH in children; nevertheless, this genetic factor may be involved in the phenotypic expression, as pressure hypersensitivity was greater in those CTTH children with the Met/Met genotype.</description><subject>631/208/2489/144</subject><subject>692/699/375/226</subject><subject>692/700/1720</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Catechol O-Methyltransferase - genetics</subject><subject>Child</subject><subject>clinical-investigation</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>General aspects</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Methionine - genetics</subject><subject>Pain Threshold - physiology</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Polymorphism, Genetic</subject><subject>Pressure</subject><subject>Tension-Type Headache - enzymology</subject><subject>Tension-Type Headache - genetics</subject><subject>Tension-Type Headache - physiopathology</subject><subject>Valine - genetics</subject><issn>0031-3998</issn><issn>1530-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EokvhHyDkCwIOKf7s2kcUoK1U1AotcIwce0xcJfbWTg4r9cfX1S5U4sBpNJpn3hk9CL2m5IQywj9ef_5-QnpCOXCqGNNCKPMErajkpCFCrJ-iFSGcNlxrdYRelHJDCBVSiefoiNFTTZlQK3R3BhHmYHGb4pxDv8whRZw8bs0Mdkhjc9V8g3nYjXM2sXjIpgC-TuNuSnk7hDLh9z_NSKWq1AccIm6HMLoMEf8K81C7nGKN30AsNbnZ7LaAz8E4Ywd4iZ55MxZ4dajH6MfXL5v2vLm8OrtoP102VjA1N45z3jugWiipHTDNBLVOCU6YZ8op7TW3vSGk93ItGdGnVBHPqiVDiXCSH6N3-9xtTrcLlLmbQrEwjiZCWkqn1FpWVWJdSbEnbU6lZPDdNofJ5F1HSfegvavau3-117U3hwNLP4H7u_THcwXeHgBTrBl9dWlDeeSElEzxB07uuVJH8Tfk7iYtOVY5_3_gHr3fm9I</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Fernández-de-Las-Peñas, César</creator><creator>Ambite-Quesada, Silvia</creator><creator>Rivas-Martínez, Inés</creator><creator>Ortega-Santiago, Ricardo</creator><creator>de-la-Llave-Rincón, Ana Isabel</creator><creator>Fernández-Mayoralas, Daniel M</creator><creator>Pareja, Juan A</creator><general>Nature Publishing Group US</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Genetic Contribution of Catechol-O-Methyltransferase Polymorphism (Val158Met) in Children With Chronic Tension-Type Headache</title><author>Fernández-de-Las-Peñas, César ; Ambite-Quesada, Silvia ; Rivas-Martínez, Inés ; Ortega-Santiago, Ricardo ; de-la-Llave-Rincón, Ana Isabel ; Fernández-Mayoralas, Daniel M ; Pareja, Juan A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-d333bde194859de29241cd84302f28d89f93cba00bf5752096180f2120a104d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>631/208/2489/144</topic><topic>692/699/375/226</topic><topic>692/700/1720</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Catechol O-Methyltransferase - genetics</topic><topic>Child</topic><topic>clinical-investigation</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>General aspects</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Methionine - genetics</topic><topic>Pain Threshold - physiology</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Polymorphism, Genetic</topic><topic>Pressure</topic><topic>Tension-Type Headache - enzymology</topic><topic>Tension-Type Headache - genetics</topic><topic>Tension-Type Headache - physiopathology</topic><topic>Valine - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernández-de-Las-Peñas, César</creatorcontrib><creatorcontrib>Ambite-Quesada, Silvia</creatorcontrib><creatorcontrib>Rivas-Martínez, Inés</creatorcontrib><creatorcontrib>Ortega-Santiago, Ricardo</creatorcontrib><creatorcontrib>de-la-Llave-Rincón, Ana Isabel</creatorcontrib><creatorcontrib>Fernández-Mayoralas, Daniel M</creatorcontrib><creatorcontrib>Pareja, Juan A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernández-de-Las-Peñas, César</au><au>Ambite-Quesada, Silvia</au><au>Rivas-Martínez, Inés</au><au>Ortega-Santiago, Ricardo</au><au>de-la-Llave-Rincón, Ana Isabel</au><au>Fernández-Mayoralas, Daniel M</au><au>Pareja, Juan A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic Contribution of Catechol-O-Methyltransferase Polymorphism (Val158Met) in Children With Chronic Tension-Type Headache</atitle><jtitle>Pediatric research</jtitle><stitle>Pediatr Res</stitle><addtitle>Pediatr Res</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>70</volume><issue>4</issue><spage>395</spage><epage>399</epage><pages>395-399</pages><issn>0031-3998</issn><eissn>1530-0447</eissn><coden>PEREBL</coden><abstract>Our aim was to investigate the relationship between Val158Met polymorphisms, headache, and pressure hypersensitivity in children with chronic tension-type headache (CTTH). A case–control study with blinded assessor was conducted. Seventy children with CTTH associated with pericranial tenderness and 70 healthy children participated. After amplifying Val158Met polymorphism by polymerase chain reactions, we assessed genotype frequencies and allele distributions. We classified children according to their Val158Met polymorphism: Val/Val, Val/Met, Met/Met. Pressure pain thresholds (PPT) were bilaterally assessed over the temporalis, upper trapezius, second metacarpal, and tibialis anterior muscles. The distribution of Val158Met genotypes was not significantly different (
p
= 0.335), between children with CTTH and healthy children, and between boys and girls (
p
= 0.872). Children with CTTH with the Met/Met genotype showed a longer headache history compared with those with Met/Val (
p
= 0.001) or Val/Val (
p
= 0.002) genotype. Children with CTTH with Met/Met genotype showed lower PPT over upper trapezius and temporalis muscles than children with CTTH with Met/Val or Val/Val genotype (
p
< 0.01). The Val158Met catechol-
O
-methyltransferase (COMT) polymorphism does not appear to be involved in predisposition to suffer from CTTH in children; nevertheless, this genetic factor may be involved in the phenotypic expression, as pressure hypersensitivity was greater in those CTTH children with the Met/Met genotype.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>21691248</pmid><doi>10.1203/PDR.0b013e318229448a</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-3998 |
| ispartof | Pediatric research, 2011-10, Vol.70 (4), p.395-399 |
| issn | 0031-3998 1530-0447 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_887503147 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 631/208/2489/144 692/699/375/226 692/700/1720 Biological and medical sciences Case-Control Studies Catechol O-Methyltransferase - genetics Child clinical-investigation Female Gene Frequency General aspects Genotype Humans Male Medical sciences Medicine Medicine & Public Health Methionine - genetics Pain Threshold - physiology Pediatric Surgery Pediatrics Polymorphism, Genetic Pressure Tension-Type Headache - enzymology Tension-Type Headache - genetics Tension-Type Headache - physiopathology Valine - genetics |
| title | Genetic Contribution of Catechol-O-Methyltransferase Polymorphism (Val158Met) in Children With Chronic Tension-Type Headache |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T13%3A04%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Genetic%20Contribution%20of%20Catechol-O-Methyltransferase%20Polymorphism%20(Val158Met)%20in%20Children%20With%20Chronic%20Tension-Type%20Headache&rft.jtitle=Pediatric%20research&rft.au=Fern%C3%A1ndez-de-Las-Pe%C3%B1as,%20C%C3%A9sar&rft.date=2011-10-01&rft.volume=70&rft.issue=4&rft.spage=395&rft.epage=399&rft.pages=395-399&rft.issn=0031-3998&rft.eissn=1530-0447&rft.coden=PEREBL&rft_id=info:doi/10.1203/PDR.0b013e318229448a&rft_dat=%3Cproquest_cross%3E887503147%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=887503147&rft_id=info:pmid/21691248&rfr_iscdi=true |