Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images

Standard optical coherence tomography (OCT) in combination with software tools can be harnessed to generate vascular maps in vivo. In this study we have successfully combined a software algorithm based on correlation statistic to reveal microcirculation morphology on OCT intensity images of a mouse...

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Veröffentlicht in:Journal of biophotonics 2011-09, Vol.4 (9), p.583-587
Hauptverfasser: Jonathan, Enock, Enfield, Joey, Leahy, Martin J.
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creator Jonathan, Enock
Enfield, Joey
Leahy, Martin J.
description Standard optical coherence tomography (OCT) in combination with software tools can be harnessed to generate vascular maps in vivo. In this study we have successfully combined a software algorithm based on correlation statistic to reveal microcirculation morphology on OCT intensity images of a mouse brain in vivo captured trans‐cranially and through a cranial window. We were able to estimate vessel geometry at bifurcation as well as along vessel segments down‐to mean diameters of about 24 μm. Our technique has potential applications in cardiovascular‐related parameter measurements such as volumetric flow as well as in assessing vascular density of normal and diseased tissue. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
doi_str_mv 10.1002/jbio.201000103
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Algorithms
Animals
Brain - blood supply
Brain - metabolism
Brain - pathology
Cardiovascular System - metabolism
Cardiovascular System - pathology
correlation
Image Processing, Computer-Assisted - methods
imaging
Mice
Microcirculation
morphology
optical coherence tomography
Sensitivity and Specificity
Software
Tomography, Optical Coherence - methods
title Correlation mapping method for generating microcirculation morphology from optical coherence tomography (OCT) intensity images
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