High-Molecular-Weight Polyethyleneimine Conjuncted Pluronic for Gene Transfer Agents

In order to enhance the gene delivery efficiency and decrease cytotoxicity of polyplexes, copolymers consisting of branched polyethyleneimine (PEI) 25 kDa grafted with Pluronic (F127, F68, P105) were successfully synthesized using a simple two-step procedure. The copolymers were tested for cytotoxic...

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Veröffentlicht in:	Chemical & Pharmaceutical Bulletin 2011/09/01, Vol.59(9), pp.1094-1101
Hauptverfasser:	Liang, Wenqing, Gong, Haiyang, Yin, Dongfeng, Lu, Shiyong, Fu, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor cytotoxicity gene delivery Humans Liposomes Molecular Weight Plasmids - chemistry Plasmids - metabolism Pluronic Poloxamer - chemistry Polyethyleneimine - chemical synthesis Polyethyleneimine - chemistry Polyethyleneimine - toxicity polyethylenimine Polymers - chemical synthesis Polymers - chemistry Polymers - toxicity polyplex Transfection
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