In Situ Follicular Lymphoma Associated With Progressive Transformation of Germinal Centers
The authors report here a case of in situ follicular lymphoma (FL) associated with progressive transformation of the germinal center (PTGC). A 39-year-old Japanese male developed a mass in the right cervical region. Biopsy of the enlarged lymph node led to a diagnosis of PTGC. Then, 5 years later, t...
Gespeichert in:
| Veröffentlicht in: | International journal of surgical pathology 2011-08, Vol.19 (4), p.521-523 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 523 |
|---|---|
| container_issue | 4 |
| container_start_page | 521 |
| container_title | International journal of surgical pathology |
| container_volume | 19 |
| creator | Handa, Tomoyuki Maki, Kazuhiro Segawa, Asuki Masawa, Nobuhide Mitani, Kinuko |
| description | The authors report here a case of in situ follicular lymphoma (FL) associated with progressive transformation of the germinal center (PTGC). A 39-year-old Japanese male developed a mass in the right cervical region. Biopsy of the enlarged lymph node led to a diagnosis of PTGC. Then, 5 years later, the lymphadenopathy recurred. The second biopsy specimens contained numerous germinal centers, including PTGC. Although most follicles were cytologically reactive, a few GCs appeared to be somewhat monotonous, composed predominantly of centrocytes and lacking mitotic figures and tangible body macrophages. Immunohistochemical studies demonstrated that these atypical GCs were CD10+, CD20+, and bcl-2+, with λ-light-chain restriction. A previous report emphasized the differential diagnostic problem between PTGC and the floral variant of FL. However, the present case indicated that in situ FL should be added to the list of differential diagnoses for PTGC. |
| doi_str_mv | 10.1177/1066896909350174 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_886917540</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1066896909350174</sage_id><sourcerecordid>886917540</sourcerecordid><originalsourceid>FETCH-LOGICAL-c336t-44080ef64e0d79c4186ecfa5941f0aa316b54cf9bf5522b9af9e6e92d7be49593</originalsourceid><addsrcrecordid>eNp1kMFLwzAUxoMobk7vniQ3T9WkTdPmOIabg4GCE8FLSbOXLaNtZl4r7L-3YwNB8PQefL_vO_wIueXsgfMse-RMylxJxVSSMp6JMzLkSrAoFjI97_8-jg75gFwhbhljsYz5JRlwpUQuEzUkn_OGvrm2o1NfVc50lQ50sa93G19rOkb0xukWVvTDtRv6Gvw6AKL7BroMukHrQ61b5xvqLZ1BqF2jKzqBpoWA1-TC6grh5nRH5H36tJw8R4uX2XwyXkQmSWQbCcFyBlYKYKtMGcFzCcbqVAlumdYJl2UqjFWlTdM4LpW2CiSoeJWVIFSqkhG5P-7ugv_qANuidmigqnQDvsMiz6XiWSpYT7IjaYJHDGCLXXC1DvuCs-IgtPgrtK_cnca7sobVb-FksAeiI4B6DcXWd6FXgP8P_gDr9X4-</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>886917540</pqid></control><display><type>article</type><title>In Situ Follicular Lymphoma Associated With Progressive Transformation of Germinal Centers</title><source>MEDLINE</source><source>SAGE Complete A-Z List</source><creator>Handa, Tomoyuki ; Maki, Kazuhiro ; Segawa, Asuki ; Masawa, Nobuhide ; Mitani, Kinuko</creator><creatorcontrib>Handa, Tomoyuki ; Maki, Kazuhiro ; Segawa, Asuki ; Masawa, Nobuhide ; Mitani, Kinuko</creatorcontrib><description>The authors report here a case of in situ follicular lymphoma (FL) associated with progressive transformation of the germinal center (PTGC). A 39-year-old Japanese male developed a mass in the right cervical region. Biopsy of the enlarged lymph node led to a diagnosis of PTGC. Then, 5 years later, the lymphadenopathy recurred. The second biopsy specimens contained numerous germinal centers, including PTGC. Although most follicles were cytologically reactive, a few GCs appeared to be somewhat monotonous, composed predominantly of centrocytes and lacking mitotic figures and tangible body macrophages. Immunohistochemical studies demonstrated that these atypical GCs were CD10+, CD20+, and bcl-2+, with λ-light-chain restriction. A previous report emphasized the differential diagnostic problem between PTGC and the floral variant of FL. However, the present case indicated that in situ FL should be added to the list of differential diagnoses for PTGC.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/1066896909350174</identifier><identifier>PMID: 19948639</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Adult ; Antigens, CD - metabolism ; Biomarkers, Tumor - metabolism ; Cell Transformation, Neoplastic ; Germinal Center - metabolism ; Germinal Center - pathology ; Humans ; Immunoglobulin gamma-Chains - genetics ; Immunoglobulin gamma-Chains - metabolism ; Lymphoma, Follicular - genetics ; Lymphoma, Follicular - metabolism ; Lymphoma, Follicular - pathology ; Male ; Neck ; Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><ispartof>International journal of surgical pathology, 2011-08, Vol.19 (4), p.521-523</ispartof><rights>The Author(s) 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-44080ef64e0d79c4186ecfa5941f0aa316b54cf9bf5522b9af9e6e92d7be49593</citedby><cites>FETCH-LOGICAL-c336t-44080ef64e0d79c4186ecfa5941f0aa316b54cf9bf5522b9af9e6e92d7be49593</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1066896909350174$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1066896909350174$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,780,784,21818,27923,27924,43620,43621</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19948639$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Handa, Tomoyuki</creatorcontrib><creatorcontrib>Maki, Kazuhiro</creatorcontrib><creatorcontrib>Segawa, Asuki</creatorcontrib><creatorcontrib>Masawa, Nobuhide</creatorcontrib><creatorcontrib>Mitani, Kinuko</creatorcontrib><title>In Situ Follicular Lymphoma Associated With Progressive Transformation of Germinal Centers</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>The authors report here a case of in situ follicular lymphoma (FL) associated with progressive transformation of the germinal center (PTGC). A 39-year-old Japanese male developed a mass in the right cervical region. Biopsy of the enlarged lymph node led to a diagnosis of PTGC. Then, 5 years later, the lymphadenopathy recurred. The second biopsy specimens contained numerous germinal centers, including PTGC. Although most follicles were cytologically reactive, a few GCs appeared to be somewhat monotonous, composed predominantly of centrocytes and lacking mitotic figures and tangible body macrophages. Immunohistochemical studies demonstrated that these atypical GCs were CD10+, CD20+, and bcl-2+, with λ-light-chain restriction. A previous report emphasized the differential diagnostic problem between PTGC and the floral variant of FL. However, the present case indicated that in situ FL should be added to the list of differential diagnoses for PTGC.</description><subject>Adult</subject><subject>Antigens, CD - metabolism</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cell Transformation, Neoplastic</subject><subject>Germinal Center - metabolism</subject><subject>Germinal Center - pathology</subject><subject>Humans</subject><subject>Immunoglobulin gamma-Chains - genetics</subject><subject>Immunoglobulin gamma-Chains - metabolism</subject><subject>Lymphoma, Follicular - genetics</subject><subject>Lymphoma, Follicular - metabolism</subject><subject>Lymphoma, Follicular - pathology</subject><subject>Male</subject><subject>Neck</subject><subject>Proto-Oncogene Proteins c-bcl-2 - metabolism</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFLwzAUxoMobk7vniQ3T9WkTdPmOIabg4GCE8FLSbOXLaNtZl4r7L-3YwNB8PQefL_vO_wIueXsgfMse-RMylxJxVSSMp6JMzLkSrAoFjI97_8-jg75gFwhbhljsYz5JRlwpUQuEzUkn_OGvrm2o1NfVc50lQ50sa93G19rOkb0xukWVvTDtRv6Gvw6AKL7BroMukHrQ61b5xvqLZ1BqF2jKzqBpoWA1-TC6grh5nRH5H36tJw8R4uX2XwyXkQmSWQbCcFyBlYKYKtMGcFzCcbqVAlumdYJl2UqjFWlTdM4LpW2CiSoeJWVIFSqkhG5P-7ugv_qANuidmigqnQDvsMiz6XiWSpYT7IjaYJHDGCLXXC1DvuCs-IgtPgrtK_cnca7sobVb-FksAeiI4B6DcXWd6FXgP8P_gDr9X4-</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Handa, Tomoyuki</creator><creator>Maki, Kazuhiro</creator><creator>Segawa, Asuki</creator><creator>Masawa, Nobuhide</creator><creator>Mitani, Kinuko</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>In Situ Follicular Lymphoma Associated With Progressive Transformation of Germinal Centers</title><author>Handa, Tomoyuki ; Maki, Kazuhiro ; Segawa, Asuki ; Masawa, Nobuhide ; Mitani, Kinuko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-44080ef64e0d79c4186ecfa5941f0aa316b54cf9bf5522b9af9e6e92d7be49593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Antigens, CD - metabolism</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cell Transformation, Neoplastic</topic><topic>Germinal Center - metabolism</topic><topic>Germinal Center - pathology</topic><topic>Humans</topic><topic>Immunoglobulin gamma-Chains - genetics</topic><topic>Immunoglobulin gamma-Chains - metabolism</topic><topic>Lymphoma, Follicular - genetics</topic><topic>Lymphoma, Follicular - metabolism</topic><topic>Lymphoma, Follicular - pathology</topic><topic>Male</topic><topic>Neck</topic><topic>Proto-Oncogene Proteins c-bcl-2 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Handa, Tomoyuki</creatorcontrib><creatorcontrib>Maki, Kazuhiro</creatorcontrib><creatorcontrib>Segawa, Asuki</creatorcontrib><creatorcontrib>Masawa, Nobuhide</creatorcontrib><creatorcontrib>Mitani, Kinuko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Handa, Tomoyuki</au><au>Maki, Kazuhiro</au><au>Segawa, Asuki</au><au>Masawa, Nobuhide</au><au>Mitani, Kinuko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Situ Follicular Lymphoma Associated With Progressive Transformation of Germinal Centers</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2011-08</date><risdate>2011</risdate><volume>19</volume><issue>4</issue><spage>521</spage><epage>523</epage><pages>521-523</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>The authors report here a case of in situ follicular lymphoma (FL) associated with progressive transformation of the germinal center (PTGC). A 39-year-old Japanese male developed a mass in the right cervical region. Biopsy of the enlarged lymph node led to a diagnosis of PTGC. Then, 5 years later, the lymphadenopathy recurred. The second biopsy specimens contained numerous germinal centers, including PTGC. Although most follicles were cytologically reactive, a few GCs appeared to be somewhat monotonous, composed predominantly of centrocytes and lacking mitotic figures and tangible body macrophages. Immunohistochemical studies demonstrated that these atypical GCs were CD10+, CD20+, and bcl-2+, with λ-light-chain restriction. A previous report emphasized the differential diagnostic problem between PTGC and the floral variant of FL. However, the present case indicated that in situ FL should be added to the list of differential diagnoses for PTGC.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>19948639</pmid><doi>10.1177/1066896909350174</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1066-8969 |
| ispartof | International journal of surgical pathology, 2011-08, Vol.19 (4), p.521-523 |
| issn | 1066-8969 1940-2465 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_886917540 |
| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Adult Antigens, CD - metabolism Biomarkers, Tumor - metabolism Cell Transformation, Neoplastic Germinal Center - metabolism Germinal Center - pathology Humans Immunoglobulin gamma-Chains - genetics Immunoglobulin gamma-Chains - metabolism Lymphoma, Follicular - genetics Lymphoma, Follicular - metabolism Lymphoma, Follicular - pathology Male Neck Proto-Oncogene Proteins c-bcl-2 - metabolism |
| title | In Situ Follicular Lymphoma Associated With Progressive Transformation of Germinal Centers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T13%3A16%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20Situ%20Follicular%20Lymphoma%20Associated%20With%20Progressive%20Transformation%20of%20Germinal%20Centers&rft.jtitle=International%20journal%20of%20surgical%20pathology&rft.au=Handa,%20Tomoyuki&rft.date=2011-08&rft.volume=19&rft.issue=4&rft.spage=521&rft.epage=523&rft.pages=521-523&rft.issn=1066-8969&rft.eissn=1940-2465&rft_id=info:doi/10.1177/1066896909350174&rft_dat=%3Cproquest_cross%3E886917540%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=886917540&rft_id=info:pmid/19948639&rft_sage_id=10.1177_1066896909350174&rfr_iscdi=true |