Incidental versus symptomatic venous thrombosis in cancer: a prospective observational study of 340 consecutive patients
The clinical significance of incidental venous thrombosis (IVT) is uncertain. The objective of this study was to compare the clinical characteristics and the outcome of cancer patients with IVT with those of patients with symptomatic venous thrombosis (SVT). Prospective observational study enrolling...
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| Veröffentlicht in: | Annals of oncology 2011-09, Vol.22 (9), p.2101-2106 |
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| container_title | Annals of oncology |
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| creator | Font, C. Farrús, B. Vidal, L. Caralt, T.M. Visa, L. Mellado, B. Tàssies, D. Monteagudo, J. Reverter, J.C. Gascon, P. |
| description | The clinical significance of incidental venous thrombosis (IVT) is uncertain. The objective of this study was to compare the clinical characteristics and the outcome of cancer patients with IVT with those of patients with symptomatic venous thrombosis (SVT).
Prospective observational study enrolling consecutive cancer patients newly diagnosed with venous thromboembolism (May 2006–April 2009). Diagnosis of IVT was based on vascular filling defects in scheduled computed tomography scans in the absence of clinical symptoms. Anticoagulant therapy was routinely prescribed regardless of SVT or IVT.
IVT was diagnosed in 94 out of 340 (28%) patients. Patients with IVT were older (63.7±10.5 versus 60.8±10.5 years, P = 0.035), more frequently had metastatic cancer (82% versus 65%, P = 0.01) and were less likely to be receiving chemotherapy at the time of the thrombotic event (53% versus 67%, P = 0.018). Mean follow-up was 477 days. A lower risk of venous rethromboses was observed in patients with IVT (log-rank P = 0.043), with no differences in major bleeding and overall survival compared with SVT patients.
A high proportion of venous thrombotic events in cancer patients are diagnosed incidentally during scheduled imaging. Prospective controlled trials evaluating the optimal therapy in this setting are required. |
| doi_str_mv | 10.1093/annonc/mdq720 |
| format | Article |
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Prospective observational study enrolling consecutive cancer patients newly diagnosed with venous thromboembolism (May 2006–April 2009). Diagnosis of IVT was based on vascular filling defects in scheduled computed tomography scans in the absence of clinical symptoms. Anticoagulant therapy was routinely prescribed regardless of SVT or IVT.
IVT was diagnosed in 94 out of 340 (28%) patients. Patients with IVT were older (63.7±10.5 versus 60.8±10.5 years, P = 0.035), more frequently had metastatic cancer (82% versus 65%, P = 0.01) and were less likely to be receiving chemotherapy at the time of the thrombotic event (53% versus 67%, P = 0.018). Mean follow-up was 477 days. A lower risk of venous rethromboses was observed in patients with IVT (log-rank P = 0.043), with no differences in major bleeding and overall survival compared with SVT patients.
A high proportion of venous thrombotic events in cancer patients are diagnosed incidentally during scheduled imaging. Prospective controlled trials evaluating the optimal therapy in this setting are required.</description><identifier>ISSN: 0923-7534</identifier><identifier>EISSN: 1569-8041</identifier><identifier>DOI: 10.1093/annonc/mdq720</identifier><identifier>PMID: 21325446</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Anticoagulants - therapeutic use ; Antineoplastic agents ; Biological and medical sciences ; Blood and lymphatic vessels ; cancer-related venous thromboembolism ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Follow-Up Studies ; Humans ; Incidence ; incidental thrombosis ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasms - blood ; Neoplasms - epidemiology ; Pharmacology. Drug treatments ; Prospective Studies ; Spain - epidemiology ; symptomatic thrombosis ; Treatment Outcome ; Venous Thrombosis - diagnosis ; Venous Thrombosis - drug therapy ; Venous Thrombosis - epidemiology ; Venous Thrombosis - etiology</subject><ispartof>Annals of oncology, 2011-09, Vol.22 (9), p.2101-2106</ispartof><rights>2011 European Society for Medical Oncology</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-321a02b000f6435b3848b578f1fedb1cb46a26f448e4c5c1957d623b1ec2b37c3</citedby><cites>FETCH-LOGICAL-c409t-321a02b000f6435b3848b578f1fedb1cb46a26f448e4c5c1957d623b1ec2b37c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24492522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21325446$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Font, C.</creatorcontrib><creatorcontrib>Farrús, B.</creatorcontrib><creatorcontrib>Vidal, L.</creatorcontrib><creatorcontrib>Caralt, T.M.</creatorcontrib><creatorcontrib>Visa, L.</creatorcontrib><creatorcontrib>Mellado, B.</creatorcontrib><creatorcontrib>Tàssies, D.</creatorcontrib><creatorcontrib>Monteagudo, J.</creatorcontrib><creatorcontrib>Reverter, J.C.</creatorcontrib><creatorcontrib>Gascon, P.</creatorcontrib><title>Incidental versus symptomatic venous thrombosis in cancer: a prospective observational study of 340 consecutive patients</title><title>Annals of oncology</title><addtitle>Ann Oncol</addtitle><description>The clinical significance of incidental venous thrombosis (IVT) is uncertain. The objective of this study was to compare the clinical characteristics and the outcome of cancer patients with IVT with those of patients with symptomatic venous thrombosis (SVT).
Prospective observational study enrolling consecutive cancer patients newly diagnosed with venous thromboembolism (May 2006–April 2009). Diagnosis of IVT was based on vascular filling defects in scheduled computed tomography scans in the absence of clinical symptoms. Anticoagulant therapy was routinely prescribed regardless of SVT or IVT.
IVT was diagnosed in 94 out of 340 (28%) patients. Patients with IVT were older (63.7±10.5 versus 60.8±10.5 years, P = 0.035), more frequently had metastatic cancer (82% versus 65%, P = 0.01) and were less likely to be receiving chemotherapy at the time of the thrombotic event (53% versus 67%, P = 0.018). Mean follow-up was 477 days. A lower risk of venous rethromboses was observed in patients with IVT (log-rank P = 0.043), with no differences in major bleeding and overall survival compared with SVT patients.
A high proportion of venous thrombotic events in cancer patients are diagnosed incidentally during scheduled imaging. Prospective controlled trials evaluating the optimal therapy in this setting are required.</description><subject>Anticoagulants - therapeutic use</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>cancer-related venous thromboembolism</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Incidence</subject><subject>incidental thrombosis</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - epidemiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Prospective Studies</subject><subject>Spain - epidemiology</subject><subject>symptomatic thrombosis</subject><subject>Treatment Outcome</subject><subject>Venous Thrombosis - diagnosis</subject><subject>Venous Thrombosis - drug therapy</subject><subject>Venous Thrombosis - epidemiology</subject><subject>Venous Thrombosis - etiology</subject><issn>0923-7534</issn><issn>1569-8041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kEtv1TAQRi0EoreFJVvkDWIV6mce7FAFpVIlNrCO7MlEGCV26kmuuP--hlxgxcrS6Mznbw5jr6R4J0Wnr12MKcL1PDw0SjxhB2nrrmqFkU_ZQXRKV43V5oJdEv0QQtSd6p6zCyW1ssbUB_bzLkIYMK5u4kfMtBGn07ysaXZrgDKKqYzW7znNPlEgHiIHFwHze-74khMtCGs4Ik-eMB_LVooli9ZtOPE0cm0EhxQJYfuNLYUo39EL9mx0E-HL83vFvn36-PXmc3X_5fbu5sN9BUZ0a6WVdEL5Un2sjbZet6b1tmlHOeLgJXhTO1WPxrRowILsbDPUSnuJoLxuQF-xt3tu6fqwIa39HAhwmlzEclrftnUnG2FlIaudhHIVZRz7JYfZ5VMvRf_Ldb-77nfXhX99Tt78jMNf-o_cArw5A47ATWMu3gL944zplFWqcM3OYfFwDJh7guIIcAi5yO2HFP5T4RH-CJ-e</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Font, C.</creator><creator>Farrús, B.</creator><creator>Vidal, L.</creator><creator>Caralt, T.M.</creator><creator>Visa, L.</creator><creator>Mellado, B.</creator><creator>Tàssies, D.</creator><creator>Monteagudo, J.</creator><creator>Reverter, J.C.</creator><creator>Gascon, P.</creator><general>Elsevier Ltd</general><general>Oxford University Press</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Incidental versus symptomatic venous thrombosis in cancer: a prospective observational study of 340 consecutive patients</title><author>Font, C. ; Farrús, B. ; Vidal, L. ; Caralt, T.M. ; Visa, L. ; Mellado, B. ; Tàssies, D. ; Monteagudo, J. ; Reverter, J.C. ; Gascon, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-321a02b000f6435b3848b578f1fedb1cb46a26f448e4c5c1957d623b1ec2b37c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Anticoagulants - therapeutic use</topic><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>cancer-related venous thromboembolism</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Incidence</topic><topic>incidental thrombosis</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - epidemiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Prospective Studies</topic><topic>Spain - epidemiology</topic><topic>symptomatic thrombosis</topic><topic>Treatment Outcome</topic><topic>Venous Thrombosis - diagnosis</topic><topic>Venous Thrombosis - drug therapy</topic><topic>Venous Thrombosis - epidemiology</topic><topic>Venous Thrombosis - etiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Font, C.</creatorcontrib><creatorcontrib>Farrús, B.</creatorcontrib><creatorcontrib>Vidal, L.</creatorcontrib><creatorcontrib>Caralt, T.M.</creatorcontrib><creatorcontrib>Visa, L.</creatorcontrib><creatorcontrib>Mellado, B.</creatorcontrib><creatorcontrib>Tàssies, D.</creatorcontrib><creatorcontrib>Monteagudo, J.</creatorcontrib><creatorcontrib>Reverter, J.C.</creatorcontrib><creatorcontrib>Gascon, P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Font, C.</au><au>Farrús, B.</au><au>Vidal, L.</au><au>Caralt, T.M.</au><au>Visa, L.</au><au>Mellado, B.</au><au>Tàssies, D.</au><au>Monteagudo, J.</au><au>Reverter, J.C.</au><au>Gascon, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Incidental versus symptomatic venous thrombosis in cancer: a prospective observational study of 340 consecutive patients</atitle><jtitle>Annals of oncology</jtitle><addtitle>Ann Oncol</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>22</volume><issue>9</issue><spage>2101</spage><epage>2106</epage><pages>2101-2106</pages><issn>0923-7534</issn><eissn>1569-8041</eissn><abstract>The clinical significance of incidental venous thrombosis (IVT) is uncertain. The objective of this study was to compare the clinical characteristics and the outcome of cancer patients with IVT with those of patients with symptomatic venous thrombosis (SVT).
Prospective observational study enrolling consecutive cancer patients newly diagnosed with venous thromboembolism (May 2006–April 2009). Diagnosis of IVT was based on vascular filling defects in scheduled computed tomography scans in the absence of clinical symptoms. Anticoagulant therapy was routinely prescribed regardless of SVT or IVT.
IVT was diagnosed in 94 out of 340 (28%) patients. Patients with IVT were older (63.7±10.5 versus 60.8±10.5 years, P = 0.035), more frequently had metastatic cancer (82% versus 65%, P = 0.01) and were less likely to be receiving chemotherapy at the time of the thrombotic event (53% versus 67%, P = 0.018). Mean follow-up was 477 days. A lower risk of venous rethromboses was observed in patients with IVT (log-rank P = 0.043), with no differences in major bleeding and overall survival compared with SVT patients.
A high proportion of venous thrombotic events in cancer patients are diagnosed incidentally during scheduled imaging. Prospective controlled trials evaluating the optimal therapy in this setting are required.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>21325446</pmid><doi>10.1093/annonc/mdq720</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Annals of oncology, 2011-09, Vol.22 (9), p.2101-2106 |
| issn | 0923-7534 1569-8041 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Anticoagulants - therapeutic use Antineoplastic agents Biological and medical sciences Blood and lymphatic vessels cancer-related venous thromboembolism Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Female Follow-Up Studies Humans Incidence incidental thrombosis Male Medical sciences Middle Aged Multivariate Analysis Neoplasms - blood Neoplasms - epidemiology Pharmacology. Drug treatments Prospective Studies Spain - epidemiology symptomatic thrombosis Treatment Outcome Venous Thrombosis - diagnosis Venous Thrombosis - drug therapy Venous Thrombosis - epidemiology Venous Thrombosis - etiology |
| title | Incidental versus symptomatic venous thrombosis in cancer: a prospective observational study of 340 consecutive patients |
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