Crushing Artifacts Resulting in Small Blue Cellular Clusters That Simulate Small Cell Carcinoma

The presence of “crushing” artifacts in histological sections is a very common finding and represents a potentially major pitfall for the surgical pathologist, particularly in small biopsy specimens. Microscopically, it appears as bluish clusters in which the cellular details are not recognizable. H...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of surgical pathology 2011-08, Vol.19 (4), p.487-491
Hauptverfasser: Flamminio, Federica, Tosi, Anna Lisa, Fellegara, Giovanni
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 491
container_issue 4
container_start_page 487
container_title International journal of surgical pathology
container_volume 19
creator Flamminio, Federica
Tosi, Anna Lisa
Fellegara, Giovanni
description The presence of “crushing” artifacts in histological sections is a very common finding and represents a potentially major pitfall for the surgical pathologist, particularly in small biopsy specimens. Microscopically, it appears as bluish clusters in which the cellular details are not recognizable. Here the authors report examples of this phenomenon that have been reported or that they have personally observed and emphasize some diagnostic clue to avoid its overinterpretation and the dire clinical consequences that this may entail.
doi_str_mv 10.1177/1066896911411187
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_886909066</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_1066896911411187</sage_id><sourcerecordid>886909066</sourcerecordid><originalsourceid>FETCH-LOGICAL-c336t-c174241a7625bbe443b1c6fd86c02c74c7b70d7f88ca3d0e6a251254c212e5ad3</originalsourceid><addsrcrecordid>eNp1kE1PwzAMhiMEYmNw54Ry41SI0zRpj6PiS5qExMa5StN065S2Ix8H_j2ZNjggIVmyZT9-Zb8IXQO5AxDiHgjnecELAAYAuThBUygYSSjj2Wms4zjZzyfowrktIYRyCudoQoGnNMYUVaUNbtMNazy3vmul8g6_axeM3_e6AS97aQx-MEHjUhsTjLS4NMF5bR1ebaTHy66PXa-P6J7CpbSqG8ZeXqKzVhqnr455hj6eHlflS7J4e34t54tEpSn3iQLBKAMpOM3qWjOW1qB42-RcEaoEU6IWpBFtniuZNkRzSTOgGVMUqM5kk87Q7UF3Z8fPoJ2v-s6peIoc9Bhclee8IEX0I5LkQCo7Omd1W-1s10v7VQGp9q5Wf12NKzdH8VD3uvld-LExAskBcHKtq-0Y7BCf_V_wG3pifq4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>886909066</pqid></control><display><type>article</type><title>Crushing Artifacts Resulting in Small Blue Cellular Clusters That Simulate Small Cell Carcinoma</title><source>MEDLINE</source><source>SAGE Complete</source><creator>Flamminio, Federica ; Tosi, Anna Lisa ; Fellegara, Giovanni</creator><creatorcontrib>Flamminio, Federica ; Tosi, Anna Lisa ; Fellegara, Giovanni</creatorcontrib><description>The presence of “crushing” artifacts in histological sections is a very common finding and represents a potentially major pitfall for the surgical pathologist, particularly in small biopsy specimens. Microscopically, it appears as bluish clusters in which the cellular details are not recognizable. Here the authors report examples of this phenomenon that have been reported or that they have personally observed and emphasize some diagnostic clue to avoid its overinterpretation and the dire clinical consequences that this may entail.</description><identifier>ISSN: 1066-8969</identifier><identifier>EISSN: 1940-2465</identifier><identifier>DOI: 10.1177/1066896911411187</identifier><identifier>PMID: 21632632</identifier><language>eng</language><publisher>Los Angeles, CA: SAGE Publications</publisher><subject>Biopsy, Needle ; Carcinoid Tumor - diagnosis ; Carcinoma, Small Cell - diagnosis ; Diagnosis, Differential ; Diagnostic Errors - prevention &amp; control ; Dura Mater - pathology ; Hematopoiesis, Extramedullary ; Histocytological Preparation Techniques - methods ; Humans ; Lung Neoplasms - diagnosis ; Lymphoid Tissue - pathology ; Male ; Spermatocele - diagnosis ; Testicular Hydrocele - diagnosis ; Thyroid Diseases - diagnosis ; Urinary Bladder - pathology</subject><ispartof>International journal of surgical pathology, 2011-08, Vol.19 (4), p.487-491</ispartof><rights>The Author(s) 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c336t-c174241a7625bbe443b1c6fd86c02c74c7b70d7f88ca3d0e6a251254c212e5ad3</citedby><cites>FETCH-LOGICAL-c336t-c174241a7625bbe443b1c6fd86c02c74c7b70d7f88ca3d0e6a251254c212e5ad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/1066896911411187$$EPDF$$P50$$Gsage$$H</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/1066896911411187$$EHTML$$P50$$Gsage$$H</linktohtml><link.rule.ids>314,776,780,21798,27901,27902,43597,43598</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21632632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Flamminio, Federica</creatorcontrib><creatorcontrib>Tosi, Anna Lisa</creatorcontrib><creatorcontrib>Fellegara, Giovanni</creatorcontrib><title>Crushing Artifacts Resulting in Small Blue Cellular Clusters That Simulate Small Cell Carcinoma</title><title>International journal of surgical pathology</title><addtitle>Int J Surg Pathol</addtitle><description>The presence of “crushing” artifacts in histological sections is a very common finding and represents a potentially major pitfall for the surgical pathologist, particularly in small biopsy specimens. Microscopically, it appears as bluish clusters in which the cellular details are not recognizable. Here the authors report examples of this phenomenon that have been reported or that they have personally observed and emphasize some diagnostic clue to avoid its overinterpretation and the dire clinical consequences that this may entail.</description><subject>Biopsy, Needle</subject><subject>Carcinoid Tumor - diagnosis</subject><subject>Carcinoma, Small Cell - diagnosis</subject><subject>Diagnosis, Differential</subject><subject>Diagnostic Errors - prevention &amp; control</subject><subject>Dura Mater - pathology</subject><subject>Hematopoiesis, Extramedullary</subject><subject>Histocytological Preparation Techniques - methods</subject><subject>Humans</subject><subject>Lung Neoplasms - diagnosis</subject><subject>Lymphoid Tissue - pathology</subject><subject>Male</subject><subject>Spermatocele - diagnosis</subject><subject>Testicular Hydrocele - diagnosis</subject><subject>Thyroid Diseases - diagnosis</subject><subject>Urinary Bladder - pathology</subject><issn>1066-8969</issn><issn>1940-2465</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1PwzAMhiMEYmNw54Ry41SI0zRpj6PiS5qExMa5StN065S2Ix8H_j2ZNjggIVmyZT9-Zb8IXQO5AxDiHgjnecELAAYAuThBUygYSSjj2Wms4zjZzyfowrktIYRyCudoQoGnNMYUVaUNbtMNazy3vmul8g6_axeM3_e6AS97aQx-MEHjUhsTjLS4NMF5bR1ebaTHy66PXa-P6J7CpbSqG8ZeXqKzVhqnr455hj6eHlflS7J4e34t54tEpSn3iQLBKAMpOM3qWjOW1qB42-RcEaoEU6IWpBFtniuZNkRzSTOgGVMUqM5kk87Q7UF3Z8fPoJ2v-s6peIoc9Bhclee8IEX0I5LkQCo7Omd1W-1s10v7VQGp9q5Wf12NKzdH8VD3uvld-LExAskBcHKtq-0Y7BCf_V_wG3pifq4</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Flamminio, Federica</creator><creator>Tosi, Anna Lisa</creator><creator>Fellegara, Giovanni</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201108</creationdate><title>Crushing Artifacts Resulting in Small Blue Cellular Clusters That Simulate Small Cell Carcinoma</title><author>Flamminio, Federica ; Tosi, Anna Lisa ; Fellegara, Giovanni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c336t-c174241a7625bbe443b1c6fd86c02c74c7b70d7f88ca3d0e6a251254c212e5ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biopsy, Needle</topic><topic>Carcinoid Tumor - diagnosis</topic><topic>Carcinoma, Small Cell - diagnosis</topic><topic>Diagnosis, Differential</topic><topic>Diagnostic Errors - prevention &amp; control</topic><topic>Dura Mater - pathology</topic><topic>Hematopoiesis, Extramedullary</topic><topic>Histocytological Preparation Techniques - methods</topic><topic>Humans</topic><topic>Lung Neoplasms - diagnosis</topic><topic>Lymphoid Tissue - pathology</topic><topic>Male</topic><topic>Spermatocele - diagnosis</topic><topic>Testicular Hydrocele - diagnosis</topic><topic>Thyroid Diseases - diagnosis</topic><topic>Urinary Bladder - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Flamminio, Federica</creatorcontrib><creatorcontrib>Tosi, Anna Lisa</creatorcontrib><creatorcontrib>Fellegara, Giovanni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of surgical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Flamminio, Federica</au><au>Tosi, Anna Lisa</au><au>Fellegara, Giovanni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crushing Artifacts Resulting in Small Blue Cellular Clusters That Simulate Small Cell Carcinoma</atitle><jtitle>International journal of surgical pathology</jtitle><addtitle>Int J Surg Pathol</addtitle><date>2011-08</date><risdate>2011</risdate><volume>19</volume><issue>4</issue><spage>487</spage><epage>491</epage><pages>487-491</pages><issn>1066-8969</issn><eissn>1940-2465</eissn><abstract>The presence of “crushing” artifacts in histological sections is a very common finding and represents a potentially major pitfall for the surgical pathologist, particularly in small biopsy specimens. Microscopically, it appears as bluish clusters in which the cellular details are not recognizable. Here the authors report examples of this phenomenon that have been reported or that they have personally observed and emphasize some diagnostic clue to avoid its overinterpretation and the dire clinical consequences that this may entail.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>21632632</pmid><doi>10.1177/1066896911411187</doi><tpages>5</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1066-8969
ispartof International journal of surgical pathology, 2011-08, Vol.19 (4), p.487-491
issn 1066-8969
1940-2465
language eng
recordid cdi_proquest_miscellaneous_886909066
source MEDLINE; SAGE Complete
subjects Biopsy, Needle
Carcinoid Tumor - diagnosis
Carcinoma, Small Cell - diagnosis
Diagnosis, Differential
Diagnostic Errors - prevention & control
Dura Mater - pathology
Hematopoiesis, Extramedullary
Histocytological Preparation Techniques - methods
Humans
Lung Neoplasms - diagnosis
Lymphoid Tissue - pathology
Male
Spermatocele - diagnosis
Testicular Hydrocele - diagnosis
Thyroid Diseases - diagnosis
Urinary Bladder - pathology
title Crushing Artifacts Resulting in Small Blue Cellular Clusters That Simulate Small Cell Carcinoma
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T11%3A38%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Crushing%20Artifacts%20Resulting%20in%20Small%20Blue%20Cellular%20Clusters%20That%20Simulate%20Small%20Cell%20Carcinoma&rft.jtitle=International%20journal%20of%20surgical%20pathology&rft.au=Flamminio,%20Federica&rft.date=2011-08&rft.volume=19&rft.issue=4&rft.spage=487&rft.epage=491&rft.pages=487-491&rft.issn=1066-8969&rft.eissn=1940-2465&rft_id=info:doi/10.1177/1066896911411187&rft_dat=%3Cproquest_cross%3E886909066%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=886909066&rft_id=info:pmid/21632632&rft_sage_id=10.1177_1066896911411187&rfr_iscdi=true