A case of colorectal cancer with double-activating epidermal growth factor receptor mutations
We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year...
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| Veröffentlicht in: | Japanese journal of clinical oncology 2011-09, Vol.41 (9), p.1138-1141 |
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| container_title | Japanese journal of clinical oncology |
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| creator | Rai, Kammei Fujiwara, Keiichi Tsushima, Mizuho Kudo, Kenichiro Mizuta, Makoto Matsuo, Kiyoshi Yonei, Toshiro Yamadori, Ichiro Kiura, Katsuyuki Sato, Toshio |
| description | We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal growth factor receptor mutations. Histological review by immunostaining concluded that the primary lung tumor was composed of metastatic tumors from rectal cancer. In addition, genetic analysis revealed that the primary rectal cancer contained nearly the same types of double-activating epidermal growth factor receptor mutations as were present in the lung tumor. This is the first report of a case of rectal adenocarcinoma with double-activating epidermal growth factor receptor mutations. |
| doi_str_mv | 10.1093/jjco/hyr113 |
| format | Article |
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She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal growth factor receptor mutations. Histological review by immunostaining concluded that the primary lung tumor was composed of metastatic tumors from rectal cancer. In addition, genetic analysis revealed that the primary rectal cancer contained nearly the same types of double-activating epidermal growth factor receptor mutations as were present in the lung tumor. This is the first report of a case of rectal adenocarcinoma with double-activating epidermal growth factor receptor mutations.</description><identifier>ISSN: 0368-2811</identifier><identifier>EISSN: 1465-3621</identifier><identifier>DOI: 10.1093/jjco/hyr113</identifier><identifier>PMID: 21835826</identifier><language>eng</language><publisher>England</publisher><subject><![CDATA[Adenocarcinoma - chemistry ; Adenocarcinoma - genetics ; Adenocarcinoma - secondary ; Aged ; Antineoplastic Agents - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - administration & dosage ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biomarkers, Tumor - analysis ; Biomarkers, Tumor - genetics ; Camptothecin - administration & dosage ; Camptothecin - analogs & derivatives ; Colorectal Neoplasms - chemistry ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; DNA Mutational Analysis ; Erlotinib Hydrochloride ; Female ; Fluorouracil - administration & dosage ; Humans ; Immunohistochemistry ; Leucovorin - administration & dosage ; Lung Neoplasms - chemistry ; Lung Neoplasms - drug therapy ; Lung Neoplasms - genetics ; Lung Neoplasms - secondary ; Mutation ; Neoplasms, Second Primary - diagnosis ; Organoplatinum Compounds - administration & dosage ; Quinazolines - therapeutic use ; Receptor, Epidermal Growth Factor - antagonists & inhibitors ; Receptor, Epidermal Growth Factor - genetics ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - secondary ; Transcriptional Activation ; Treatment Failure ; Treatment Outcome]]></subject><ispartof>Japanese journal of clinical oncology, 2011-09, Vol.41 (9), p.1138-1141</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-223f16b49f876e7f11b1658df98360acbbc2269772a2fbeb432c1f1729f413b33</citedby><cites>FETCH-LOGICAL-c349t-223f16b49f876e7f11b1658df98360acbbc2269772a2fbeb432c1f1729f413b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21835826$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rai, Kammei</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Tsushima, Mizuho</creatorcontrib><creatorcontrib>Kudo, Kenichiro</creatorcontrib><creatorcontrib>Mizuta, Makoto</creatorcontrib><creatorcontrib>Matsuo, Kiyoshi</creatorcontrib><creatorcontrib>Yonei, Toshiro</creatorcontrib><creatorcontrib>Yamadori, Ichiro</creatorcontrib><creatorcontrib>Kiura, Katsuyuki</creatorcontrib><creatorcontrib>Sato, Toshio</creatorcontrib><title>A case of colorectal cancer with double-activating epidermal growth factor receptor mutations</title><title>Japanese journal of clinical oncology</title><addtitle>Jpn J Clin Oncol</addtitle><description>We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal growth factor receptor mutations. Histological review by immunostaining concluded that the primary lung tumor was composed of metastatic tumors from rectal cancer. In addition, genetic analysis revealed that the primary rectal cancer contained nearly the same types of double-activating epidermal growth factor receptor mutations as were present in the lung tumor. This is the first report of a case of rectal adenocarcinoma with double-activating epidermal growth factor receptor mutations.</description><subject>Adenocarcinoma - chemistry</subject><subject>Adenocarcinoma - genetics</subject><subject>Adenocarcinoma - secondary</subject><subject>Aged</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Camptothecin - administration & dosage</subject><subject>Camptothecin - analogs & derivatives</subject><subject>Colorectal Neoplasms - chemistry</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>DNA Mutational Analysis</subject><subject>Erlotinib Hydrochloride</subject><subject>Female</subject><subject>Fluorouracil - administration & dosage</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Leucovorin - administration & dosage</subject><subject>Lung Neoplasms - chemistry</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - secondary</subject><subject>Mutation</subject><subject>Neoplasms, Second Primary - diagnosis</subject><subject>Organoplatinum Compounds - administration & dosage</subject><subject>Quinazolines - therapeutic use</subject><subject>Receptor, Epidermal Growth Factor - antagonists & inhibitors</subject><subject>Receptor, Epidermal Growth Factor - genetics</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - secondary</subject><subject>Transcriptional Activation</subject><subject>Treatment Failure</subject><subject>Treatment Outcome</subject><issn>0368-2811</issn><issn>1465-3621</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAQhi0EoqUwsaNsDCjUZzuOM1YVX1IlFhhRZDt2myqJg51Q9d_jqoXpTvc-9w4PQreAHwEXdL7dajff7D0APUNTYDxLKSdwjqaYcpESATBBVyFsMcaZYPklmhAQNBOET9HXItEymMTZRLvGeaMH2cRTp41PdvWwSSo3qsakUg_1jxzqbp2Yvq6MbyO39m4XERtD55P4bPrD0o5DJF0XrtGFlU0wN6c5Q5_PTx_L13T1_vK2XKxSTVkxpIRQC1yxwoqcm9wCKOCZqGwhKMdSK6UJ4UWeE0msMopRosFCTgrLgCpKZ-j-2Nt79z2aMJRtHbRpGtkZN4ZSCM4xo4xH8uFIau9C8MaWva9b6fcl4PKgszzoLI86I3136h1Va6p_9s8f_QVgQ3Lr</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Rai, Kammei</creator><creator>Fujiwara, Keiichi</creator><creator>Tsushima, Mizuho</creator><creator>Kudo, Kenichiro</creator><creator>Mizuta, Makoto</creator><creator>Matsuo, Kiyoshi</creator><creator>Yonei, Toshiro</creator><creator>Yamadori, Ichiro</creator><creator>Kiura, Katsuyuki</creator><creator>Sato, Toshio</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>A case of colorectal cancer with double-activating epidermal growth factor receptor mutations</title><author>Rai, Kammei ; Fujiwara, Keiichi ; Tsushima, Mizuho ; Kudo, Kenichiro ; Mizuta, Makoto ; Matsuo, Kiyoshi ; Yonei, Toshiro ; Yamadori, Ichiro ; Kiura, Katsuyuki ; Sato, Toshio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-223f16b49f876e7f11b1658df98360acbbc2269772a2fbeb432c1f1729f413b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adenocarcinoma - chemistry</topic><topic>Adenocarcinoma - genetics</topic><topic>Adenocarcinoma - secondary</topic><topic>Aged</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Antineoplastic Combined Chemotherapy Protocols - administration & dosage</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Camptothecin - administration & dosage</topic><topic>Camptothecin - analogs & derivatives</topic><topic>Colorectal Neoplasms - chemistry</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>DNA Mutational Analysis</topic><topic>Erlotinib Hydrochloride</topic><topic>Female</topic><topic>Fluorouracil - administration & dosage</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Leucovorin - administration & dosage</topic><topic>Lung Neoplasms - chemistry</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - secondary</topic><topic>Mutation</topic><topic>Neoplasms, Second Primary - diagnosis</topic><topic>Organoplatinum Compounds - administration & dosage</topic><topic>Quinazolines - therapeutic use</topic><topic>Receptor, Epidermal Growth Factor - antagonists & inhibitors</topic><topic>Receptor, Epidermal Growth Factor - genetics</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - secondary</topic><topic>Transcriptional Activation</topic><topic>Treatment Failure</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rai, Kammei</creatorcontrib><creatorcontrib>Fujiwara, Keiichi</creatorcontrib><creatorcontrib>Tsushima, Mizuho</creatorcontrib><creatorcontrib>Kudo, Kenichiro</creatorcontrib><creatorcontrib>Mizuta, Makoto</creatorcontrib><creatorcontrib>Matsuo, Kiyoshi</creatorcontrib><creatorcontrib>Yonei, Toshiro</creatorcontrib><creatorcontrib>Yamadori, Ichiro</creatorcontrib><creatorcontrib>Kiura, Katsuyuki</creatorcontrib><creatorcontrib>Sato, Toshio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rai, Kammei</au><au>Fujiwara, Keiichi</au><au>Tsushima, Mizuho</au><au>Kudo, Kenichiro</au><au>Mizuta, Makoto</au><au>Matsuo, Kiyoshi</au><au>Yonei, Toshiro</au><au>Yamadori, Ichiro</au><au>Kiura, Katsuyuki</au><au>Sato, Toshio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A case of colorectal cancer with double-activating epidermal growth factor receptor mutations</atitle><jtitle>Japanese journal of clinical oncology</jtitle><addtitle>Jpn J Clin Oncol</addtitle><date>2011-09</date><risdate>2011</risdate><volume>41</volume><issue>9</issue><spage>1138</spage><epage>1141</epage><pages>1138-1141</pages><issn>0368-2811</issn><eissn>1465-3621</eissn><abstract>We describe the case of a 72-year-old woman with locally advanced lung tumor mimicking primary lung cancer. She was diagnosed with rectal cancer at the age of 65 years and was initially treated with platinum-based chemotherapy and thoracic irradiation as a treatment for primary lung cancer. One year later, a thyroid tumor was detected in her right thyroid lobe and was confirmed to have metastasized from rectal cancer based on pathological findings. Therefore, we suspected that she had metachronous double cancers and treated her with conventional chemotherapy for colorectal cancer. However, new life-threatening multiple lung metastases appeared. We treated her with the drug erlotinib because additional genetic analysis against primary lung tumor revealed typical double-activating epidermal growth factor receptor mutations. Histological review by immunostaining concluded that the primary lung tumor was composed of metastatic tumors from rectal cancer. In addition, genetic analysis revealed that the primary rectal cancer contained nearly the same types of double-activating epidermal growth factor receptor mutations as were present in the lung tumor. This is the first report of a case of rectal adenocarcinoma with double-activating epidermal growth factor receptor mutations.</abstract><cop>England</cop><pmid>21835826</pmid><doi>10.1093/jjco/hyr113</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Japanese journal of clinical oncology, 2011-09, Vol.41 (9), p.1138-1141 |
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| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adenocarcinoma - chemistry Adenocarcinoma - genetics Adenocarcinoma - secondary Aged Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biomarkers, Tumor - analysis Biomarkers, Tumor - genetics Camptothecin - administration & dosage Camptothecin - analogs & derivatives Colorectal Neoplasms - chemistry Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA Mutational Analysis Erlotinib Hydrochloride Female Fluorouracil - administration & dosage Humans Immunohistochemistry Leucovorin - administration & dosage Lung Neoplasms - chemistry Lung Neoplasms - drug therapy Lung Neoplasms - genetics Lung Neoplasms - secondary Mutation Neoplasms, Second Primary - diagnosis Organoplatinum Compounds - administration & dosage Quinazolines - therapeutic use Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Thyroid Neoplasms - genetics Thyroid Neoplasms - secondary Transcriptional Activation Treatment Failure Treatment Outcome |
| title | A case of colorectal cancer with double-activating epidermal growth factor receptor mutations |
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