Association of −308 TNF-α promoter polymorphism with clinical aggressiveness in patients with head and neck squamous cell carcinoma

Summary Genetic polymorphisms in the promoter region of the tumour necrosis factor-α ( TNF-α ) gene are involved in the regulation of the expression levels of its cytokine. Besides, these polymorphisms have been associated with the clinical behaviour of cancer. We investigated the −308 promoter regi...

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Veröffentlicht in:	Oral oncology 2011-09, Vol.47 (9), p.888-894
Hauptverfasser:	Corrêa, Gefter Thiago Batista, Bandeira, Gabriela Alencar, Cavalcanti, Bruna Gonçalves, de Carvalho Fraga, Carlos Alberto, dos Santos, Erivelton Pereira, Silva, Thiago Fonseca, Gomez, Ricardo Santiago, Guimarães, André Luiz Sena, De Paula, Alfredo Maurício Batista
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Clinicopathological factors Dermatology Female Follow-Up Studies Genetic Predisposition to Disease Head and neck Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Hematology, Oncology and Palliative Medicine Humans Male Medical sciences Middle Aged Otolaryngology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Polymerase Chain Reaction - methods Polymorphism Polymorphism, Restriction Fragment Length - genetics Prognosis Promoter Regions, Genetic - genetics Retrospective Studies Risk Factors Squamous cell carcinoma Survival Survival Analysis TNF-α Tumor Necrosis Factor-alpha - genetics Tumors Tumors of the skin and soft tissue. Premalignant lesions
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