Deletion mapping and paternal origin of a Mexican AMELY negative male
Abstract The amelogenin represents the gender marker most widely used for human identification and biomedical purposes. However, some failures in sex-typing have been observed globally. In this study, we could approximate the population frequency of AMELY negative males in 1230 individuals from five...
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| Veröffentlicht in: | Legal medicine (Tokyo, Japan) Japan), 2011-09, Vol.13 (5), p.262-264 |
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| creator | Velarde-Félix, J.S Salazar-Flores, J Martínez-Cortés, G Flores García, A Muñoz-Valle, J.F Ríos-Tostado, J.J Rubi-Castellanos, R Rangel-Villalobos, H |
| description | Abstract The amelogenin represents the gender marker most widely used for human identification and biomedical purposes. However, some failures in sex-typing have been observed globally. In this study, we could approximate the population frequency of AMELY negative males in 1230 individuals from five states of Mexico (0.081%). For the sole AMELY negative male detected, we constructed a deletion map by means of 10 markers (7 STS and 3 Y-STRs). This allowed classifying the case into the most common category (Class I deletion), according to the nomenclature proposed by Jobling et al. (2007). Interestingly, the Mexican sample was R1a1∗ , a Y-chromosome haplogroup non-previously reported for AMELY negative cases. The geographic distribution of R1a1∗ , and the Y-STR haplotype similarity with a reported case from Slovenia, suggests an Eastern-Europe paternal origin for this case from Mexico. To our knowledge, this is the first report in Latin America that implies a low population frequency and European paternal origin of AMELY negative cases. |
| doi_str_mv | 10.1016/j.legalmed.2011.06.001 |
| format | Article |
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However, some failures in sex-typing have been observed globally. In this study, we could approximate the population frequency of AMELY negative males in 1230 individuals from five states of Mexico (0.081%). For the sole AMELY negative male detected, we constructed a deletion map by means of 10 markers (7 STS and 3 Y-STRs). This allowed classifying the case into the most common category (Class I deletion), according to the nomenclature proposed by Jobling et al. (2007). Interestingly, the Mexican sample was R1a1∗ , a Y-chromosome haplogroup non-previously reported for AMELY negative cases. The geographic distribution of R1a1∗ , and the Y-STR haplotype similarity with a reported case from Slovenia, suggests an Eastern-Europe paternal origin for this case from Mexico. To our knowledge, this is the first report in Latin America that implies a low population frequency and European paternal origin of AMELY negative cases.</description><identifier>ISSN: 1344-6223</identifier><identifier>EISSN: 1873-4162</identifier><identifier>DOI: 10.1016/j.legalmed.2011.06.001</identifier><identifier>PMID: 21821457</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Amelogenin - genetics ; AMELY deletions ; AMELY negative ; Base Sequence ; Chromosome Deletion ; Female ; Gender-typing ; Genetics, Population ; Humans ; Internal Medicine ; Mexican population ; Mexico - ethnology ; Paternity ; Sex-typing</subject><ispartof>Legal medicine (Tokyo, Japan), 2011-09, Vol.13 (5), p.262-264</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2011 Elsevier Ireland Ltd</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c446t-452c24e440a2fd0695e946f3f03484fb3ad58cd28d3105215c1a0d623278c0ae3</citedby><cites>FETCH-LOGICAL-c446t-452c24e440a2fd0695e946f3f03484fb3ad58cd28d3105215c1a0d623278c0ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1344622311000812$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21821457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Velarde-Félix, J.S</creatorcontrib><creatorcontrib>Salazar-Flores, J</creatorcontrib><creatorcontrib>Martínez-Cortés, G</creatorcontrib><creatorcontrib>Flores García, A</creatorcontrib><creatorcontrib>Muñoz-Valle, J.F</creatorcontrib><creatorcontrib>Ríos-Tostado, J.J</creatorcontrib><creatorcontrib>Rubi-Castellanos, R</creatorcontrib><creatorcontrib>Rangel-Villalobos, H</creatorcontrib><title>Deletion mapping and paternal origin of a Mexican AMELY negative male</title><title>Legal medicine (Tokyo, Japan)</title><addtitle>Leg Med (Tokyo)</addtitle><description>Abstract The amelogenin represents the gender marker most widely used for human identification and biomedical purposes. However, some failures in sex-typing have been observed globally. In this study, we could approximate the population frequency of AMELY negative males in 1230 individuals from five states of Mexico (0.081%). For the sole AMELY negative male detected, we constructed a deletion map by means of 10 markers (7 STS and 3 Y-STRs). This allowed classifying the case into the most common category (Class I deletion), according to the nomenclature proposed by Jobling et al. (2007). Interestingly, the Mexican sample was R1a1∗ , a Y-chromosome haplogroup non-previously reported for AMELY negative cases. The geographic distribution of R1a1∗ , and the Y-STR haplotype similarity with a reported case from Slovenia, suggests an Eastern-Europe paternal origin for this case from Mexico. To our knowledge, this is the first report in Latin America that implies a low population frequency and European paternal origin of AMELY negative cases.</description><subject>Adult</subject><subject>Amelogenin - genetics</subject><subject>AMELY deletions</subject><subject>AMELY negative</subject><subject>Base Sequence</subject><subject>Chromosome Deletion</subject><subject>Female</subject><subject>Gender-typing</subject><subject>Genetics, Population</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Mexican population</subject><subject>Mexico - ethnology</subject><subject>Paternity</subject><subject>Sex-typing</subject><issn>1344-6223</issn><issn>1873-4162</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0Eoh_wF6rcOCXM2I6TvSCqdqFIW3EADpws156svHidYGcr-u9xtN0LF0625OedV36GsSuEBgHV-10TaGvCnlzDAbEB1QDgC3aOfSdqiYq_LHchZa04F2fsIuddATqE7jU749hzlG13zta3FGj2Y6z2Zpp83FYmumoyM6VoQjUmv_WxGofKVPf0x1sTq-v79eZnFUv97B-p5AK9Ya8GEzK9fT4v2Y9P6-83d_Xm6-cvN9eb2kqp5lq23HJJUoLhgwO1amkl1SAGELKXw4Mwru2t470TCC3H1qIBp7jgXW_BkLhk745zpzT-PlCe9d5nSyGYSOMh675X7WqF2BZSHUmbxpwTDXpKfm_Sk0bQi0G90yeDejGoQekiqASvnisOD8vbKXZSVoCPR4DKRx89JZ2tp2jJ-UR21m70_-_48M8IG3wscsMveqK8Gw-L_KxRZ65Bf1v2uKwREQB65OIvnKCX4Q</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Velarde-Félix, J.S</creator><creator>Salazar-Flores, J</creator><creator>Martínez-Cortés, G</creator><creator>Flores García, A</creator><creator>Muñoz-Valle, J.F</creator><creator>Ríos-Tostado, J.J</creator><creator>Rubi-Castellanos, R</creator><creator>Rangel-Villalobos, H</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Deletion mapping and paternal origin of a Mexican AMELY negative male</title><author>Velarde-Félix, J.S ; Salazar-Flores, J ; Martínez-Cortés, G ; Flores García, A ; Muñoz-Valle, J.F ; Ríos-Tostado, J.J ; Rubi-Castellanos, R ; Rangel-Villalobos, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-452c24e440a2fd0695e946f3f03484fb3ad58cd28d3105215c1a0d623278c0ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Amelogenin - genetics</topic><topic>AMELY deletions</topic><topic>AMELY negative</topic><topic>Base Sequence</topic><topic>Chromosome Deletion</topic><topic>Female</topic><topic>Gender-typing</topic><topic>Genetics, Population</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Mexican population</topic><topic>Mexico - ethnology</topic><topic>Paternity</topic><topic>Sex-typing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velarde-Félix, J.S</creatorcontrib><creatorcontrib>Salazar-Flores, J</creatorcontrib><creatorcontrib>Martínez-Cortés, G</creatorcontrib><creatorcontrib>Flores García, A</creatorcontrib><creatorcontrib>Muñoz-Valle, J.F</creatorcontrib><creatorcontrib>Ríos-Tostado, J.J</creatorcontrib><creatorcontrib>Rubi-Castellanos, R</creatorcontrib><creatorcontrib>Rangel-Villalobos, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Legal medicine (Tokyo, Japan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velarde-Félix, J.S</au><au>Salazar-Flores, J</au><au>Martínez-Cortés, G</au><au>Flores García, A</au><au>Muñoz-Valle, J.F</au><au>Ríos-Tostado, J.J</au><au>Rubi-Castellanos, R</au><au>Rangel-Villalobos, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Deletion mapping and paternal origin of a Mexican AMELY negative male</atitle><jtitle>Legal medicine (Tokyo, Japan)</jtitle><addtitle>Leg Med (Tokyo)</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>13</volume><issue>5</issue><spage>262</spage><epage>264</epage><pages>262-264</pages><issn>1344-6223</issn><eissn>1873-4162</eissn><abstract>Abstract The amelogenin represents the gender marker most widely used for human identification and biomedical purposes. However, some failures in sex-typing have been observed globally. In this study, we could approximate the population frequency of AMELY negative males in 1230 individuals from five states of Mexico (0.081%). For the sole AMELY negative male detected, we constructed a deletion map by means of 10 markers (7 STS and 3 Y-STRs). This allowed classifying the case into the most common category (Class I deletion), according to the nomenclature proposed by Jobling et al. (2007). Interestingly, the Mexican sample was R1a1∗ , a Y-chromosome haplogroup non-previously reported for AMELY negative cases. The geographic distribution of R1a1∗ , and the Y-STR haplotype similarity with a reported case from Slovenia, suggests an Eastern-Europe paternal origin for this case from Mexico. To our knowledge, this is the first report in Latin America that implies a low population frequency and European paternal origin of AMELY negative cases.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>21821457</pmid><doi>10.1016/j.legalmed.2011.06.001</doi><tpages>3</tpages></addata></record> |
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| subjects | Adult Amelogenin - genetics AMELY deletions AMELY negative Base Sequence Chromosome Deletion Female Gender-typing Genetics, Population Humans Internal Medicine Mexican population Mexico - ethnology Paternity Sex-typing |
| title | Deletion mapping and paternal origin of a Mexican AMELY negative male |
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