Edaravone-loaded liposomes for retinal protection against oxidative stress-induced retinal damage

Edaravone-loaded liposomes significantly reduced N-methyl- d-aspartate(NMDA)-induced retinal damage compared with free edaravone after intravitreal injection. To optimize the retinal protective effects of submicron-sized liposomes (ssLips) containing edaravone for intravitreal administration, we inv...

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Veröffentlicht in:	European journal of pharmaceutics and biopharmaceutics 2011-09, Vol.79 (1), p.119-125
Hauptverfasser:	Hironaka, Kohei, Inokuchi, Yuta, Fujisawa, Takuya, Shimazaki, Hiroki, Akane, Mai, Tozuka, Yuichi, Tsuruma, Kazuhiro, Shimazawa, Masamitsu, Hara, Hideaki, Takeuchi, Hirofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipyrine - analogs & derivatives Antipyrine - chemistry Antipyrine - pharmacology Calcium acetate gradient method Cell Line Drug Compounding Drug Delivery Systems Edaravone Excitatory Amino Acid Agonists - metabolism Eye - metabolism Eye - pathology Free Radical Scavengers - analysis Free Radical Scavengers - chemistry Intravitreal injection Intravitreal Injections Liposome Liposomes - analysis Liposomes - chemistry Male Mice Molecular Targeted Therapy N-Methylaspartate - metabolism Oxidative stress Oxidative Stress - drug effects Oxidative Stress - physiology Phospholipids - chemistry Phospholipids - metabolism Protective Agents - chemistry Protective Agents - pharmacology Retina Retina - drug effects Retina - metabolism Retina - pathology Retinal Diseases - chemically induced Retinal Diseases - drug therapy Retinal Diseases - metabolism Retinal Diseases - prevention & control
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