Induction of diabetes with signs of autoimmunity in primates by the injection of multiple-low-dose streptozotocin

► Diabetes can be induced in primates in a reliable and consistent manner with MLD-STZ. ► The induced diabetes was associated with autoimmune responses to pancreatic islet β cells. ► The first report demonstrating success at inducing the β cell directed autoimmunity in primates. To develop a preclin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2011-08, Vol.412 (2), p.373-378
Hauptverfasser:	Wei, Lingling, Lu, Yanrong, He, Sirong, Jin, Xi, Zeng, Li, Zhang, Shuang, Chen, Younan, Tian, Bole, Mai, Gang, Yang, Guang, Zhang, Jie, Wang, Li, Li, Hongxia, Markmann, James F., Cheng, Jingqiu, Deng, Shaoping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal model Animal models Animals Autoantibodies - blood Autoimmunity Diabetes Mellitus, Type 1 - chemically induced Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - pathology Disease Models, Animal Dose-Response Relationship, Drug Female Islets of Langerhans - immunology Islets of Langerhans - pathology Macaca mulatta Male Multiple-low-dose streptozotocin Rhesus monkey Streptozocin - administration & dosage Type 1 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!