Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth
Maternal separation and poor maternal care in animals have been shown to have important effects on the developing hippocampus and amygdala. In humans, children exposed to abuse/maltreatment or orphanage rearing do not present changes in hippocampal volumes. However, children reared in orphanages pre...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2011-08, Vol.108 (34), p.14324-14329 |
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| creator | Lupien, Sonia J Parent, Sophie Evans, Alan C Tremblay, Richard E Zelazo, Philip David Corbo, Vincent Pruessner, Jens C Séguin, Jean R |
| description | Maternal separation and poor maternal care in animals have been shown to have important effects on the developing hippocampus and amygdala. In humans, children exposed to abuse/maltreatment or orphanage rearing do not present changes in hippocampal volumes. However, children reared in orphanages present enlarged amygdala volumes, suggesting that the amygdala may be particularly sensitive to severely disturbed (i.e., discontinous, neglectful) care in infancy. Maternal depressive symptomatology has been associated with reductions in overall sensitivity to the infant, and with an increased rate of withdrawn, disengaged behaviors. To determine if poor maternal care associated with maternal depressive symptomatology has a similar pattern of association to the volumes of the hippocampus and amygdala in children, as is the case for severely disturbed infant care (orphanage rearing), we measured hippocampal and amygdala volumes as well as stress hormone (glucocorticoid) levels in children exposed (n = 17) or not (n = 21) to maternal depressive symptomatology since birth. Results revealed no group difference in hippocampal volumes, but larger left and right amygdala volumes and increased levels of glucocorticoids in the children of mothers presenting depressive symptomatology since birth. Moreover, a significant positive correlation was observed between mothers' mean depressive scores and amygdala volumes in their children. The results of this study suggest that amygdala volume in human children may represent an early marker of biological sensitivity to quality of maternal care. |
| doi_str_mv | 10.1073/pnas.1105371108 |
| format | Article |
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In humans, children exposed to abuse/maltreatment or orphanage rearing do not present changes in hippocampal volumes. However, children reared in orphanages present enlarged amygdala volumes, suggesting that the amygdala may be particularly sensitive to severely disturbed (i.e., discontinous, neglectful) care in infancy. Maternal depressive symptomatology has been associated with reductions in overall sensitivity to the infant, and with an increased rate of withdrawn, disengaged behaviors. To determine if poor maternal care associated with maternal depressive symptomatology has a similar pattern of association to the volumes of the hippocampus and amygdala in children, as is the case for severely disturbed infant care (orphanage rearing), we measured hippocampal and amygdala volumes as well as stress hormone (glucocorticoid) levels in children exposed (n = 17) or not (n = 21) to maternal depressive symptomatology since birth. Results revealed no group difference in hippocampal volumes, but larger left and right amygdala volumes and increased levels of glucocorticoids in the children of mothers presenting depressive symptomatology since birth. Moreover, a significant positive correlation was observed between mothers' mean depressive scores and amygdala volumes in their children. The results of this study suggest that amygdala volume in human children may represent an early marker of biological sensitivity to quality of maternal care.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1105371108</identifier><identifier>PMID: 21844357</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Adolescent ; Amygdala ; Amygdala - pathology ; Behavioral neuroscience ; Biological Sciences ; Brain ; Child ; child care ; Child development ; Child rearing ; Child, Preschool ; Childhood ; Childhood mental disorders ; Children ; Children & youth ; Correlation analysis ; Depressive Disorder - pathology ; Depressive disorders ; Female ; Glucocorticoids ; Hippocampus ; Hippocampus - pathology ; Humans ; Hydrocortisone - metabolism ; infancy ; Infant ; Infant, Newborn ; Male ; Maternal Behavior ; Mental depression ; mothers ; Organ Size ; parturition ; Quality of care ; rearing ; Saliva - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2011-08, Vol.108 (34), p.14324-14329</ispartof><rights>copyright © 1993–2008 National Academy of Sciences of the United States of America</rights><rights>Copyright National Academy of Sciences Aug 23, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c490t-5d8ad8d67195bb647ebd1c364449856165bc1a271ea3230196fc4dfa2ffebbe83</citedby><cites>FETCH-LOGICAL-c490t-5d8ad8d67195bb647ebd1c364449856165bc1a271ea3230196fc4dfa2ffebbe83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/108/34.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/27979505$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/27979505$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21844357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lupien, Sonia J</creatorcontrib><creatorcontrib>Parent, Sophie</creatorcontrib><creatorcontrib>Evans, Alan C</creatorcontrib><creatorcontrib>Tremblay, Richard E</creatorcontrib><creatorcontrib>Zelazo, Philip David</creatorcontrib><creatorcontrib>Corbo, Vincent</creatorcontrib><creatorcontrib>Pruessner, Jens C</creatorcontrib><creatorcontrib>Séguin, Jean R</creatorcontrib><title>Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Maternal separation and poor maternal care in animals have been shown to have important effects on the developing hippocampus and amygdala. In humans, children exposed to abuse/maltreatment or orphanage rearing do not present changes in hippocampal volumes. However, children reared in orphanages present enlarged amygdala volumes, suggesting that the amygdala may be particularly sensitive to severely disturbed (i.e., discontinous, neglectful) care in infancy. Maternal depressive symptomatology has been associated with reductions in overall sensitivity to the infant, and with an increased rate of withdrawn, disengaged behaviors. To determine if poor maternal care associated with maternal depressive symptomatology has a similar pattern of association to the volumes of the hippocampus and amygdala in children, as is the case for severely disturbed infant care (orphanage rearing), we measured hippocampal and amygdala volumes as well as stress hormone (glucocorticoid) levels in children exposed (n = 17) or not (n = 21) to maternal depressive symptomatology since birth. Results revealed no group difference in hippocampal volumes, but larger left and right amygdala volumes and increased levels of glucocorticoids in the children of mothers presenting depressive symptomatology since birth. Moreover, a significant positive correlation was observed between mothers' mean depressive scores and amygdala volumes in their children. 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Results revealed no group difference in hippocampal volumes, but larger left and right amygdala volumes and increased levels of glucocorticoids in the children of mothers presenting depressive symptomatology since birth. Moreover, a significant positive correlation was observed between mothers' mean depressive scores and amygdala volumes in their children. The results of this study suggest that amygdala volume in human children may represent an early marker of biological sensitivity to quality of maternal care.</abstract><cop>United States</cop><pub>National Academy of Sciences</pub><pmid>21844357</pmid><doi>10.1073/pnas.1105371108</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Amygdala Amygdala - pathology Behavioral neuroscience Biological Sciences Brain Child child care Child development Child rearing Child, Preschool Childhood Childhood mental disorders Children Children & youth Correlation analysis Depressive Disorder - pathology Depressive disorders Female Glucocorticoids Hippocampus Hippocampus - pathology Humans Hydrocortisone - metabolism infancy Infant Infant, Newborn Male Maternal Behavior Mental depression mothers Organ Size parturition Quality of care rearing Saliva - metabolism |
| title | Larger amygdala but no change in hippocampal volume in 10-year-old children exposed to maternal depressive symptomatology since birth |
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