Characterization of IgA and IgM binding and internalization by surface-expressed human Fcα/μ receptor

► Recombinant human Fcα/μreceptor expressed on surface of human cell line. ► Dissociation constants for binding of human IgA and IgM to Fcα/μR are reported. ► IgM polymers do not require J chain for binding to Fcα/μR. ► IgA lacking N-linked glycans can associate with Fcα/μR. ► IgA can be internalize...

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Veröffentlicht in:	Molecular immunology 2011-09, Vol.48 (15-16), p.1818-1826
Hauptverfasser:	Yoo, Esther M., Trinh, K. Ryan, Lim, Hana, Wims, Letitia A., Morrison, Sherie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Cell Separation Fc receptor Fcα/μR Flow Cytometry Humans IgA IgM Immunoglobulin A - chemistry Immunoglobulin A - metabolism Immunoglobulin M - chemistry Immunoglobulin M - metabolism Internalization Receptors, Fc - metabolism Transfection
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