Physical therapy assessment tools to evaluate disease progression and phenotype variability in Golden Retriever muscular dystrophy
Dogs suffering from Golden Retriever muscular dystrophy (GRMD) present symptoms that are similar to human patients with Duchenne muscular dystrophy (DMD). Phenotypic variability is common in both cases and correlates with disease progression and response to therapy. Physical therapy assessment tools...
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| Veröffentlicht in: | Research in veterinary science 2011-10, Vol.91 (2), p.188-193 |
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| creator | Gaiad, T.P. Silva, M.B. Silva, G.C.A. Caromano, F.A. Miglino, M.A. Ambrósio, C.E. |
| description | Dogs suffering from Golden Retriever muscular dystrophy (GRMD) present symptoms that are similar to human patients with Duchenne muscular dystrophy (DMD). Phenotypic variability is common in both cases and correlates with disease progression and response to therapy. Physical therapy assessment tools were used to study disease progression and assess phenotypic variability in dogs with GRMD. At 5 (T0), 9 (T1), 13 (T2) and 17 (T3)
months of age, the physical features, joint ranges of motion (ROM), limb and thorax circumferences, weight and creatine kinase (CK) levels were assessed in 11 dogs with GRMD. Alterations of physical features were higher at 13
months, and different disease progression rates were observed. Passive ROM decreased until 1
year old, which was followed by a decline of elbow and tarsal ROM. Limb and thorax circumferences, which were corrected for body weight, decreased significantly between T0 and T3. These measurements can be used to evaluate disease progression in dogs with GRMD and to help discover new therapies for DMD patients. |
| doi_str_mv | 10.1016/j.rvsc.2011.01.007 |
| format | Article |
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months of age, the physical features, joint ranges of motion (ROM), limb and thorax circumferences, weight and creatine kinase (CK) levels were assessed in 11 dogs with GRMD. Alterations of physical features were higher at 13
months, and different disease progression rates were observed. Passive ROM decreased until 1
year old, which was followed by a decline of elbow and tarsal ROM. Limb and thorax circumferences, which were corrected for body weight, decreased significantly between T0 and T3. These measurements can be used to evaluate disease progression in dogs with GRMD and to help discover new therapies for DMD patients.</description><identifier>ISSN: 0034-5288</identifier><identifier>EISSN: 1532-2661</identifier><identifier>DOI: 10.1016/j.rvsc.2011.01.007</identifier><identifier>PMID: 21315399</identifier><language>eng</language><publisher>England: Elsevier India Pvt Ltd</publisher><subject>Animals ; Brazil ; Canine model ; Disease Models, Animal ; Disease Progression ; Dog Diseases - diagnosis ; Dog Diseases - physiopathology ; Dog Diseases - therapy ; Dogs ; Duchenne muscular dystrophy ; Female ; Humans ; Limb circumference ; Male ; Muscle, Skeletal - physiopathology ; Muscular Dystrophy, Animal - diagnosis ; Muscular Dystrophy, Animal - physiopathology ; Muscular Dystrophy, Animal - therapy ; Muscular Dystrophy, Duchenne - physiopathology ; Muscular Dystrophy, Duchenne - therapy ; Pathology, Veterinary - methods ; Phenotype ; Phenotypic variability ; Physical Examination - veterinary ; Physical features ; Physical Therapy Modalities - veterinary ; Range of motion ; Veterinary medicine</subject><ispartof>Research in veterinary science, 2011-10, Vol.91 (2), p.188-193</ispartof><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-d8ebe9c7f5b55408692f9e4d762b0c2efd3124c65bfcd0de30b6a46e94f9bb443</citedby><cites>FETCH-LOGICAL-c383t-d8ebe9c7f5b55408692f9e4d762b0c2efd3124c65bfcd0de30b6a46e94f9bb443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rvsc.2011.01.007$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21315399$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gaiad, T.P.</creatorcontrib><creatorcontrib>Silva, M.B.</creatorcontrib><creatorcontrib>Silva, G.C.A.</creatorcontrib><creatorcontrib>Caromano, F.A.</creatorcontrib><creatorcontrib>Miglino, M.A.</creatorcontrib><creatorcontrib>Ambrósio, C.E.</creatorcontrib><title>Physical therapy assessment tools to evaluate disease progression and phenotype variability in Golden Retriever muscular dystrophy</title><title>Research in veterinary science</title><addtitle>Res Vet Sci</addtitle><description>Dogs suffering from Golden Retriever muscular dystrophy (GRMD) present symptoms that are similar to human patients with Duchenne muscular dystrophy (DMD). Phenotypic variability is common in both cases and correlates with disease progression and response to therapy. Physical therapy assessment tools were used to study disease progression and assess phenotypic variability in dogs with GRMD. At 5 (T0), 9 (T1), 13 (T2) and 17 (T3)
months of age, the physical features, joint ranges of motion (ROM), limb and thorax circumferences, weight and creatine kinase (CK) levels were assessed in 11 dogs with GRMD. Alterations of physical features were higher at 13
months, and different disease progression rates were observed. Passive ROM decreased until 1
year old, which was followed by a decline of elbow and tarsal ROM. Limb and thorax circumferences, which were corrected for body weight, decreased significantly between T0 and T3. These measurements can be used to evaluate disease progression in dogs with GRMD and to help discover new therapies for DMD patients.</description><subject>Animals</subject><subject>Brazil</subject><subject>Canine model</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Dog Diseases - diagnosis</subject><subject>Dog Diseases - physiopathology</subject><subject>Dog Diseases - therapy</subject><subject>Dogs</subject><subject>Duchenne muscular dystrophy</subject><subject>Female</subject><subject>Humans</subject><subject>Limb circumference</subject><subject>Male</subject><subject>Muscle, Skeletal - physiopathology</subject><subject>Muscular Dystrophy, Animal - diagnosis</subject><subject>Muscular Dystrophy, Animal - physiopathology</subject><subject>Muscular Dystrophy, Animal - therapy</subject><subject>Muscular Dystrophy, Duchenne - physiopathology</subject><subject>Muscular Dystrophy, Duchenne - therapy</subject><subject>Pathology, Veterinary - methods</subject><subject>Phenotype</subject><subject>Phenotypic variability</subject><subject>Physical Examination - veterinary</subject><subject>Physical features</subject><subject>Physical Therapy Modalities - veterinary</subject><subject>Range of motion</subject><subject>Veterinary medicine</subject><issn>0034-5288</issn><issn>1532-2661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGL1TAUhYM4OM_RP-BCAi5c9U2SNm0DbmQYR2FgRHQd0uTWl0fb1Ny00O38cvN4owsXwuHezXcPh3sIecPZnjNeXx_3cUW7F4zzPctizTOy47IUhahr_pzsGCurQoq2vSQvEY-MsYrz5gW5FLzMnFI78vj1sKG3ZqDpANHMGzWIgDjClGgKYcA8KaxmWEwC6jyCQaBzDD9jxnyYqJkcnQ8whbTNQFcTven84NNG_UTvwuBgot8gRQ8rRDouaJfBROo2TDHMh-0VuejNgPD6aV-RH59uv998Lu4f7r7cfLwvbNmWqXAtdKBs08tOyoq1tRK9gso1teiYFdC7kovK1rLrrWMOStbVpqpBVb3quqoqr8j7s28O_2sBTHr0aGEYzARhQd22UrFGKpXJd_-Qx7DEKYfTnJUyf1HIk584UzYGxAi9nqMfTdwypE8F6aM-FaRPBWmWxZp89PbJeulGcH9P_jSSgQ9nAPIrVg9Ro_UwWXA-gk3aBf8__99DXqWq</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Gaiad, T.P.</creator><creator>Silva, M.B.</creator><creator>Silva, G.C.A.</creator><creator>Caromano, F.A.</creator><creator>Miglino, M.A.</creator><creator>Ambrósio, C.E.</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Physical therapy assessment tools to evaluate disease progression and phenotype variability in Golden Retriever muscular dystrophy</title><author>Gaiad, T.P. ; 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Phenotypic variability is common in both cases and correlates with disease progression and response to therapy. Physical therapy assessment tools were used to study disease progression and assess phenotypic variability in dogs with GRMD. At 5 (T0), 9 (T1), 13 (T2) and 17 (T3)
months of age, the physical features, joint ranges of motion (ROM), limb and thorax circumferences, weight and creatine kinase (CK) levels were assessed in 11 dogs with GRMD. Alterations of physical features were higher at 13
months, and different disease progression rates were observed. Passive ROM decreased until 1
year old, which was followed by a decline of elbow and tarsal ROM. Limb and thorax circumferences, which were corrected for body weight, decreased significantly between T0 and T3. These measurements can be used to evaluate disease progression in dogs with GRMD and to help discover new therapies for DMD patients.</abstract><cop>England</cop><pub>Elsevier India Pvt Ltd</pub><pmid>21315399</pmid><doi>10.1016/j.rvsc.2011.01.007</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Brazil Canine model Disease Models, Animal Disease Progression Dog Diseases - diagnosis Dog Diseases - physiopathology Dog Diseases - therapy Dogs Duchenne muscular dystrophy Female Humans Limb circumference Male Muscle, Skeletal - physiopathology Muscular Dystrophy, Animal - diagnosis Muscular Dystrophy, Animal - physiopathology Muscular Dystrophy, Animal - therapy Muscular Dystrophy, Duchenne - physiopathology Muscular Dystrophy, Duchenne - therapy Pathology, Veterinary - methods Phenotype Phenotypic variability Physical Examination - veterinary Physical features Physical Therapy Modalities - veterinary Range of motion Veterinary medicine |
| title | Physical therapy assessment tools to evaluate disease progression and phenotype variability in Golden Retriever muscular dystrophy |
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