Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: A review
The terahertz region of the electromagnetic spectrum spans the frequency range between the infrared and the microwave. Traditionally the exploitation of this spectral region has been difficult owing to the lack of suitable source and detector. Over the last ten years or so, terahertz technology has...
Gespeichert in:
| Veröffentlicht in: | International journal of pharmaceutics 2011-09, Vol.417 (1), p.48-60 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 60 |
|---|---|
| container_issue | 1 |
| container_start_page | 48 |
| container_title | International journal of pharmaceutics |
| container_volume | 417 |
| creator | Shen, Yao-Chun |
| description | The terahertz region of the electromagnetic spectrum spans the frequency range between the infrared and the microwave. Traditionally the exploitation of this spectral region has been difficult owing to the lack of suitable source and detector. Over the last ten years or so, terahertz technology has advanced considerably with both terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) instruments now commercially available. This review outlines some of the recent pharmaceutical applications of terahertz pulsed spectroscopy and imaging. The following application areas are highlighted: (1) discrimination and quantification of polymorphs/hydrates, (2) analysis of solid form transformation dynamics, (3) quantitative characterisation of tablet coatings: off-line and on-line, (4) tablet coating and dissolution, (5) spectroscopic imaging and chemical mapping. This review does not attempt to offer an exhaustive assessment of all anticipated pharmaceutical applications; rather it is an attempt to raise the awareness of the emerging opportunities and usefulness offered by this exciting technology. |
| doi_str_mv | 10.1016/j.ijpharm.2011.01.012 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_885903625</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378517311000263</els_id><sourcerecordid>885903625</sourcerecordid><originalsourceid>FETCH-LOGICAL-c454t-ff9805f2ede394284164b611b257b7a2ae83fe6afbd74b55e2c357cf70a04f963</originalsourceid><addsrcrecordid>eNqFkMtu2zAQRYmiRe0k_YS23HUll2_K2RSGkUeBAFkkWRMUNbRpyJJKSimcry9VO9kGGGBmce-dmYPQV0oWlFD1c7cIu35r437BCKULMhX7gOa01LzgQquPaE64LgtJNZ-hs5R2hBDFKP-MZowyrpkic_TwCNFuIQ4vuB-bBDVOPbghdsl1_QHbtsZhbzeh3WDfRfx_o3UwDsHZBtu-b_IwhK5Nl3iFIzwH-HuBPnmbs76c-jl6ur56XN8Wd_c3v9eru8IJKYbC-2VJpGdQA18KVgqqRKUorZjUlbbMQsk9KOurWotKSmCOS-28JpYIv1T8HP045vax-zNCGsw-JAdNY1voxmTKUi4JV0xmpTwqXX4sRfCmj_mteDCUmAmn2ZkTTjPhNGQqln3fThvGag_1m-uVXxZ8Pwq87YzdxJDM00NOkCTbhZDTkb-OCsgkMp1okgvQOqhDzKBN3YV3jvgH-PKTIQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>885903625</pqid></control><display><type>article</type><title>Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: A review</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Shen, Yao-Chun</creator><creatorcontrib>Shen, Yao-Chun</creatorcontrib><description>The terahertz region of the electromagnetic spectrum spans the frequency range between the infrared and the microwave. Traditionally the exploitation of this spectral region has been difficult owing to the lack of suitable source and detector. Over the last ten years or so, terahertz technology has advanced considerably with both terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) instruments now commercially available. This review outlines some of the recent pharmaceutical applications of terahertz pulsed spectroscopy and imaging. The following application areas are highlighted: (1) discrimination and quantification of polymorphs/hydrates, (2) analysis of solid form transformation dynamics, (3) quantitative characterisation of tablet coatings: off-line and on-line, (4) tablet coating and dissolution, (5) spectroscopic imaging and chemical mapping. This review does not attempt to offer an exhaustive assessment of all anticipated pharmaceutical applications; rather it is an attempt to raise the awareness of the emerging opportunities and usefulness offered by this exciting technology.</description><identifier>ISSN: 0378-5173</identifier><identifier>EISSN: 1873-3476</identifier><identifier>DOI: 10.1016/j.ijpharm.2011.01.012</identifier><identifier>PMID: 21237260</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Chemistry, Pharmaceutical - methods ; Coating ; coatings ; Humans ; image analysis ; Imaging ; Pharmaceutical Preparations - chemistry ; Polymorph ; Spectroscopy ; Tablet ; Technology, Pharmaceutical - methods ; Terahertz ; Terahertz Imaging - methods ; Terahertz Spectroscopy - methods</subject><ispartof>International journal of pharmaceutics, 2011-09, Vol.417 (1), p.48-60</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-ff9805f2ede394284164b611b257b7a2ae83fe6afbd74b55e2c357cf70a04f963</citedby><cites>FETCH-LOGICAL-c454t-ff9805f2ede394284164b611b257b7a2ae83fe6afbd74b55e2c357cf70a04f963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijpharm.2011.01.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21237260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Yao-Chun</creatorcontrib><title>Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: A review</title><title>International journal of pharmaceutics</title><addtitle>Int J Pharm</addtitle><description>The terahertz region of the electromagnetic spectrum spans the frequency range between the infrared and the microwave. Traditionally the exploitation of this spectral region has been difficult owing to the lack of suitable source and detector. Over the last ten years or so, terahertz technology has advanced considerably with both terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) instruments now commercially available. This review outlines some of the recent pharmaceutical applications of terahertz pulsed spectroscopy and imaging. The following application areas are highlighted: (1) discrimination and quantification of polymorphs/hydrates, (2) analysis of solid form transformation dynamics, (3) quantitative characterisation of tablet coatings: off-line and on-line, (4) tablet coating and dissolution, (5) spectroscopic imaging and chemical mapping. This review does not attempt to offer an exhaustive assessment of all anticipated pharmaceutical applications; rather it is an attempt to raise the awareness of the emerging opportunities and usefulness offered by this exciting technology.</description><subject>Chemistry, Pharmaceutical - methods</subject><subject>Coating</subject><subject>coatings</subject><subject>Humans</subject><subject>image analysis</subject><subject>Imaging</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Polymorph</subject><subject>Spectroscopy</subject><subject>Tablet</subject><subject>Technology, Pharmaceutical - methods</subject><subject>Terahertz</subject><subject>Terahertz Imaging - methods</subject><subject>Terahertz Spectroscopy - methods</subject><issn>0378-5173</issn><issn>1873-3476</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtu2zAQRYmiRe0k_YS23HUll2_K2RSGkUeBAFkkWRMUNbRpyJJKSimcry9VO9kGGGBmce-dmYPQV0oWlFD1c7cIu35r437BCKULMhX7gOa01LzgQquPaE64LgtJNZ-hs5R2hBDFKP-MZowyrpkic_TwCNFuIQ4vuB-bBDVOPbghdsl1_QHbtsZhbzeh3WDfRfx_o3UwDsHZBtu-b_IwhK5Nl3iFIzwH-HuBPnmbs76c-jl6ur56XN8Wd_c3v9eru8IJKYbC-2VJpGdQA18KVgqqRKUorZjUlbbMQsk9KOurWotKSmCOS-28JpYIv1T8HP045vax-zNCGsw-JAdNY1voxmTKUi4JV0xmpTwqXX4sRfCmj_mteDCUmAmn2ZkTTjPhNGQqln3fThvGag_1m-uVXxZ8Pwq87YzdxJDM00NOkCTbhZDTkb-OCsgkMp1okgvQOqhDzKBN3YV3jvgH-PKTIQ</recordid><startdate>20110930</startdate><enddate>20110930</enddate><creator>Shen, Yao-Chun</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110930</creationdate><title>Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: A review</title><author>Shen, Yao-Chun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-ff9805f2ede394284164b611b257b7a2ae83fe6afbd74b55e2c357cf70a04f963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Chemistry, Pharmaceutical - methods</topic><topic>Coating</topic><topic>coatings</topic><topic>Humans</topic><topic>image analysis</topic><topic>Imaging</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Polymorph</topic><topic>Spectroscopy</topic><topic>Tablet</topic><topic>Technology, Pharmaceutical - methods</topic><topic>Terahertz</topic><topic>Terahertz Imaging - methods</topic><topic>Terahertz Spectroscopy - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Yao-Chun</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of pharmaceutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Yao-Chun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: A review</atitle><jtitle>International journal of pharmaceutics</jtitle><addtitle>Int J Pharm</addtitle><date>2011-09-30</date><risdate>2011</risdate><volume>417</volume><issue>1</issue><spage>48</spage><epage>60</epage><pages>48-60</pages><issn>0378-5173</issn><eissn>1873-3476</eissn><abstract>The terahertz region of the electromagnetic spectrum spans the frequency range between the infrared and the microwave. Traditionally the exploitation of this spectral region has been difficult owing to the lack of suitable source and detector. Over the last ten years or so, terahertz technology has advanced considerably with both terahertz pulsed spectroscopy (TPS) and terahertz pulsed imaging (TPI) instruments now commercially available. This review outlines some of the recent pharmaceutical applications of terahertz pulsed spectroscopy and imaging. The following application areas are highlighted: (1) discrimination and quantification of polymorphs/hydrates, (2) analysis of solid form transformation dynamics, (3) quantitative characterisation of tablet coatings: off-line and on-line, (4) tablet coating and dissolution, (5) spectroscopic imaging and chemical mapping. This review does not attempt to offer an exhaustive assessment of all anticipated pharmaceutical applications; rather it is an attempt to raise the awareness of the emerging opportunities and usefulness offered by this exciting technology.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21237260</pmid><doi>10.1016/j.ijpharm.2011.01.012</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-5173 |
| ispartof | International journal of pharmaceutics, 2011-09, Vol.417 (1), p.48-60 |
| issn | 0378-5173 1873-3476 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_885903625 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Chemistry, Pharmaceutical - methods Coating coatings Humans image analysis Imaging Pharmaceutical Preparations - chemistry Polymorph Spectroscopy Tablet Technology, Pharmaceutical - methods Terahertz Terahertz Imaging - methods Terahertz Spectroscopy - methods |
| title | Terahertz pulsed spectroscopy and imaging for pharmaceutical applications: A review |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-06T13%3A59%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Terahertz%20pulsed%20spectroscopy%20and%20imaging%20for%20pharmaceutical%20applications:%20A%20review&rft.jtitle=International%20journal%20of%20pharmaceutics&rft.au=Shen,%20Yao-Chun&rft.date=2011-09-30&rft.volume=417&rft.issue=1&rft.spage=48&rft.epage=60&rft.pages=48-60&rft.issn=0378-5173&rft.eissn=1873-3476&rft_id=info:doi/10.1016/j.ijpharm.2011.01.012&rft_dat=%3Cproquest_cross%3E885903625%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=885903625&rft_id=info:pmid/21237260&rft_els_id=S0378517311000263&rfr_iscdi=true |