Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates
Abstract In this study, 112 Escherichia coli and 55 Klebsiella pneumoniae isolates with a multidrug-resistant (MDR) phenotype were collected from 2007 to 2009. All isolates simultaneously exhibited resistance to cefotaxime (or ceftazidime), ciprofloxacin (or levofloxacin) and amikacin. Plasmid-media...
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| Veröffentlicht in: | International journal of antimicrobial agents 2011-10, Vol.38 (4), p.348-351 |
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| description | Abstract In this study, 112 Escherichia coli and 55 Klebsiella pneumoniae isolates with a multidrug-resistant (MDR) phenotype were collected from 2007 to 2009. All isolates simultaneously exhibited resistance to cefotaxime (or ceftazidime), ciprofloxacin (or levofloxacin) and amikacin. Plasmid-mediated 16S rRNA methylases, including armA , rmtA , rmtB , rmtC , rmtD , rmtE and npmA , were detected by polymerase chain reaction (PCR) amplification. Common β-lactamase genes, including blaTEM , blaSHV , blaCTX-M , blaPER , blaVEB , blaGES and blaOXA , as well as plasmid-mediated blaAmpC and plasmid-mediated quinolone resistance (PMQR) determinants, including qnrA , qnrB , qnrS , qepA and aac(6 ′ )-Ib-cr , were also screened. The transferable capacity of resistance plasmids was established by conjugation testing. The genetic relatedness of isolates was analysed by pulsed-field gel electrophoresis (PFGE). Only armA and rmtB genes were detected in this study. Data showed that 93.8% of MDR E. coli and 94.5% of MDR K. pneumoniae carried at least one of armA or rmtB . The armA and rmtB genes were present in 11.6% and 82.1% of MDR E. coli , respectively. In parallel, 58.2% and 40.0% of MDR K. pneumoniae were armA - and rmtB -positive, respectively. Furthermore, the qepA gene was present in 66.3% of rmtB -carrying MDR E. coli , but it was rarely detected in MDR K. pneumoniae . Approximately 71.9% of armA -positive MDR K. pneumoniae simultaneously co-carried qnrB and blaDHA . Moreover, 78.1% and 63.6%, respectively, of armA -positive and rmtB -positive MDR K. pneumoniae strains harboured qnr alleles and 53.1% and 59.1% harboured aac(6 ′ )-Ib-cr . In addition, MDR E. coli strains exhibited a low prevalence of qnr alleles and aac(6 ′ )-Ib-cr . PFGE analysis revealed divergent genetic relatedness, suggesting horizontal dissemination of armA and rmtB along with common β-lactamases and PMQR determinants amongst clinical MDR E. coli and K. pneumoniae isolates. |
| doi_str_mv | 10.1016/j.ijantimicag.2011.04.021 |
| format | Article |
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All isolates simultaneously exhibited resistance to cefotaxime (or ceftazidime), ciprofloxacin (or levofloxacin) and amikacin. Plasmid-mediated 16S rRNA methylases, including armA , rmtA , rmtB , rmtC , rmtD , rmtE and npmA , were detected by polymerase chain reaction (PCR) amplification. Common β-lactamase genes, including blaTEM , blaSHV , blaCTX-M , blaPER , blaVEB , blaGES and blaOXA , as well as plasmid-mediated blaAmpC and plasmid-mediated quinolone resistance (PMQR) determinants, including qnrA , qnrB , qnrS , qepA and aac(6 ′ )-Ib-cr , were also screened. The transferable capacity of resistance plasmids was established by conjugation testing. The genetic relatedness of isolates was analysed by pulsed-field gel electrophoresis (PFGE). Only armA and rmtB genes were detected in this study. Data showed that 93.8% of MDR E. coli and 94.5% of MDR K. pneumoniae carried at least one of armA or rmtB . The armA and rmtB genes were present in 11.6% and 82.1% of MDR E. coli , respectively. In parallel, 58.2% and 40.0% of MDR K. pneumoniae were armA - and rmtB -positive, respectively. Furthermore, the qepA gene was present in 66.3% of rmtB -carrying MDR E. coli , but it was rarely detected in MDR K. pneumoniae . Approximately 71.9% of armA -positive MDR K. pneumoniae simultaneously co-carried qnrB and blaDHA . Moreover, 78.1% and 63.6%, respectively, of armA -positive and rmtB -positive MDR K. pneumoniae strains harboured qnr alleles and 53.1% and 59.1% harboured aac(6 ′ )-Ib-cr . In addition, MDR E. coli strains exhibited a low prevalence of qnr alleles and aac(6 ′ )-Ib-cr . PFGE analysis revealed divergent genetic relatedness, suggesting horizontal dissemination of armA and rmtB along with common β-lactamases and PMQR determinants amongst clinical MDR E. coli and K. pneumoniae isolates.</description><identifier>ISSN: 0924-8579</identifier><identifier>EISSN: 1872-7913</identifier><identifier>DOI: 10.1016/j.ijantimicag.2011.04.021</identifier><identifier>PMID: 21724374</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>16S rRNA methylase ; alleles ; amikacin ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; beta-lactamase ; beta-Lactamases - genetics ; beta-Lactamases - isolation & purification ; Biological and medical sciences ; cefotaxime ; ciprofloxacin ; Conjugation, Genetic - physiology ; DNA, Bacterial - analysis ; Drug Resistance, Bacterial - drug effects ; Drug Resistance, Bacterial - genetics ; Drug Resistance, Multiple, Bacterial - genetics ; Escherichia coli ; Escherichia coli - enzymology ; Escherichia coli - genetics ; Escherichia coli - isolation & purification ; Escherichia coli Proteins - genetics ; genetic relationships ; Humans ; Infectious Disease ; Klebsiella pneumoniae ; Klebsiella pneumoniae - enzymology ; Klebsiella pneumoniae - genetics ; Klebsiella pneumoniae - isolation & purification ; Medical sciences ; Methyltransferases - genetics ; Microbial Sensitivity Tests ; Multidrug-resistant ; multiple drug resistance ; Pharmacology. Drug treatments ; phenotype ; plasmids ; Plasmids - metabolism ; polymerase chain reaction ; Prevalence ; pulsed-field gel electrophoresis ; RNA, Ribosomal, 16S - metabolism</subject><ispartof>International journal of antimicrobial agents, 2011-10, Vol.38 (4), p.348-351</ispartof><rights>Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2011 Elsevier B.V. and the International Society of Chemotherapy</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-651a44c03b3a393165d6eb5f4ad95fe484b9e07b7fa8fe623a09636330dad74e3</citedby><cites>FETCH-LOGICAL-c485t-651a44c03b3a393165d6eb5f4ad95fe484b9e07b7fa8fe623a09636330dad74e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijantimicag.2011.04.021$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24500597$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21724374$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Jiyong</creatorcontrib><creatorcontrib>Ye, Liyan</creatorcontrib><creatorcontrib>Wang, Weiwei</creatorcontrib><creatorcontrib>Luo, Yanping</creatorcontrib><creatorcontrib>Zhang, Youjiang</creatorcontrib><creatorcontrib>Han, Li</creatorcontrib><title>Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates</title><title>International journal of antimicrobial agents</title><addtitle>Int J Antimicrob Agents</addtitle><description>Abstract In this study, 112 Escherichia coli and 55 Klebsiella pneumoniae isolates with a multidrug-resistant (MDR) phenotype were collected from 2007 to 2009. All isolates simultaneously exhibited resistance to cefotaxime (or ceftazidime), ciprofloxacin (or levofloxacin) and amikacin. Plasmid-mediated 16S rRNA methylases, including armA , rmtA , rmtB , rmtC , rmtD , rmtE and npmA , were detected by polymerase chain reaction (PCR) amplification. Common β-lactamase genes, including blaTEM , blaSHV , blaCTX-M , blaPER , blaVEB , blaGES and blaOXA , as well as plasmid-mediated blaAmpC and plasmid-mediated quinolone resistance (PMQR) determinants, including qnrA , qnrB , qnrS , qepA and aac(6 ′ )-Ib-cr , were also screened. The transferable capacity of resistance plasmids was established by conjugation testing. The genetic relatedness of isolates was analysed by pulsed-field gel electrophoresis (PFGE). Only armA and rmtB genes were detected in this study. Data showed that 93.8% of MDR E. coli and 94.5% of MDR K. pneumoniae carried at least one of armA or rmtB . The armA and rmtB genes were present in 11.6% and 82.1% of MDR E. coli , respectively. In parallel, 58.2% and 40.0% of MDR K. pneumoniae were armA - and rmtB -positive, respectively. Furthermore, the qepA gene was present in 66.3% of rmtB -carrying MDR E. coli , but it was rarely detected in MDR K. pneumoniae . Approximately 71.9% of armA -positive MDR K. pneumoniae simultaneously co-carried qnrB and blaDHA . Moreover, 78.1% and 63.6%, respectively, of armA -positive and rmtB -positive MDR K. pneumoniae strains harboured qnr alleles and 53.1% and 59.1% harboured aac(6 ′ )-Ib-cr . In addition, MDR E. coli strains exhibited a low prevalence of qnr alleles and aac(6 ′ )-Ib-cr . PFGE analysis revealed divergent genetic relatedness, suggesting horizontal dissemination of armA and rmtB along with common β-lactamases and PMQR determinants amongst clinical MDR E. coli and K. pneumoniae isolates.</description><subject>16S rRNA methylase</subject><subject>alleles</subject><subject>amikacin</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>beta-lactamase</subject><subject>beta-Lactamases - genetics</subject><subject>beta-Lactamases - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>cefotaxime</subject><subject>ciprofloxacin</subject><subject>Conjugation, Genetic - physiology</subject><subject>DNA, Bacterial - analysis</subject><subject>Drug Resistance, Bacterial - drug effects</subject><subject>Drug Resistance, Bacterial - genetics</subject><subject>Drug Resistance, Multiple, Bacterial - genetics</subject><subject>Escherichia coli</subject><subject>Escherichia coli - enzymology</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli - isolation & purification</subject><subject>Escherichia coli Proteins - genetics</subject><subject>genetic relationships</subject><subject>Humans</subject><subject>Infectious Disease</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - enzymology</subject><subject>Klebsiella pneumoniae - genetics</subject><subject>Klebsiella pneumoniae - isolation & purification</subject><subject>Medical sciences</subject><subject>Methyltransferases - genetics</subject><subject>Microbial Sensitivity Tests</subject><subject>Multidrug-resistant</subject><subject>multiple drug resistance</subject><subject>Pharmacology. Drug treatments</subject><subject>phenotype</subject><subject>plasmids</subject><subject>Plasmids - metabolism</subject><subject>polymerase chain reaction</subject><subject>Prevalence</subject><subject>pulsed-field gel electrophoresis</subject><subject>RNA, Ribosomal, 16S - metabolism</subject><issn>0924-8579</issn><issn>1872-7913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk2P0zAQhiMEYsvCXwBzQJwS_JmPC1Ipy4dYgUTZszVxJq2Lk3TtpFJ_CP8Xh3YBceLkg5-ZeTXPJMlzRjNGWf5ql9kd9KPtrIFNxiljGZUZ5exesmBlwdOiYuJ-sqAVl2mpiuoieRTCjlKmhFQPkwvOCi5FIRfJj7f2gD4g2Xs8gMPeIBlawvI18V8_L0mH4_boIAIb7DEQ8N2SQN8Q341vCHRDvwkjMc72MYsj3eRG2_hpk3oMNowxJbkKZovemq0FYgZnf5V_clgHi84B2fc4xT4WkNgwOBgxPE4etOACPjm_l8nNu6tvqw_p9Zf3H1fL69TIUo1prhhIaaioBYhKsFw1OdaqldBUqkVZyrpCWtRFC2WLORdAq1zkQtAGmkKiuExenvru_XA7YRh1Z4OZU_U4TEGXpaqooCWNZHUijR9C8Njqvbcd-KNmVM9S9E7_JUXPUjSVOkqJtU_PU6a6w-Z35Z2FCLw4AxDiFlsPvbHhDycVpaoqIvfsxLUwaNj4yNys46T4zcpI8UisTgTGrR0seh2MnaU21qMZdTPY_wr8-p8ud4K_4xHDbph8H7VopgPXVK_nO5vPjDFKORel-AkXntDe</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Yang, Jiyong</creator><creator>Ye, Liyan</creator><creator>Wang, Weiwei</creator><creator>Luo, Yanping</creator><creator>Zhang, Youjiang</creator><creator>Han, Li</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111001</creationdate><title>Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates</title><author>Yang, Jiyong ; Ye, Liyan ; Wang, Weiwei ; Luo, Yanping ; Zhang, Youjiang ; Han, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-651a44c03b3a393165d6eb5f4ad95fe484b9e07b7fa8fe623a09636330dad74e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>16S rRNA methylase</topic><topic>alleles</topic><topic>amikacin</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>beta-lactamase</topic><topic>beta-Lactamases - genetics</topic><topic>beta-Lactamases - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>cefotaxime</topic><topic>ciprofloxacin</topic><topic>Conjugation, Genetic - physiology</topic><topic>DNA, Bacterial - analysis</topic><topic>Drug Resistance, Bacterial - drug effects</topic><topic>Drug Resistance, Bacterial - genetics</topic><topic>Drug Resistance, Multiple, Bacterial - genetics</topic><topic>Escherichia coli</topic><topic>Escherichia coli - enzymology</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli - isolation & purification</topic><topic>Escherichia coli Proteins - genetics</topic><topic>genetic relationships</topic><topic>Humans</topic><topic>Infectious Disease</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - enzymology</topic><topic>Klebsiella pneumoniae - genetics</topic><topic>Klebsiella pneumoniae - isolation & purification</topic><topic>Medical sciences</topic><topic>Methyltransferases - genetics</topic><topic>Microbial Sensitivity Tests</topic><topic>Multidrug-resistant</topic><topic>multiple drug resistance</topic><topic>Pharmacology. Drug treatments</topic><topic>phenotype</topic><topic>plasmids</topic><topic>Plasmids - metabolism</topic><topic>polymerase chain reaction</topic><topic>Prevalence</topic><topic>pulsed-field gel electrophoresis</topic><topic>RNA, Ribosomal, 16S - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Jiyong</creatorcontrib><creatorcontrib>Ye, Liyan</creatorcontrib><creatorcontrib>Wang, Weiwei</creatorcontrib><creatorcontrib>Luo, Yanping</creatorcontrib><creatorcontrib>Zhang, Youjiang</creatorcontrib><creatorcontrib>Han, Li</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of antimicrobial agents</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Jiyong</au><au>Ye, Liyan</au><au>Wang, Weiwei</au><au>Luo, Yanping</au><au>Zhang, Youjiang</au><au>Han, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates</atitle><jtitle>International journal of antimicrobial agents</jtitle><addtitle>Int J Antimicrob Agents</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>38</volume><issue>4</issue><spage>348</spage><epage>351</epage><pages>348-351</pages><issn>0924-8579</issn><eissn>1872-7913</eissn><abstract>Abstract In this study, 112 Escherichia coli and 55 Klebsiella pneumoniae isolates with a multidrug-resistant (MDR) phenotype were collected from 2007 to 2009. All isolates simultaneously exhibited resistance to cefotaxime (or ceftazidime), ciprofloxacin (or levofloxacin) and amikacin. Plasmid-mediated 16S rRNA methylases, including armA , rmtA , rmtB , rmtC , rmtD , rmtE and npmA , were detected by polymerase chain reaction (PCR) amplification. Common β-lactamase genes, including blaTEM , blaSHV , blaCTX-M , blaPER , blaVEB , blaGES and blaOXA , as well as plasmid-mediated blaAmpC and plasmid-mediated quinolone resistance (PMQR) determinants, including qnrA , qnrB , qnrS , qepA and aac(6 ′ )-Ib-cr , were also screened. The transferable capacity of resistance plasmids was established by conjugation testing. The genetic relatedness of isolates was analysed by pulsed-field gel electrophoresis (PFGE). Only armA and rmtB genes were detected in this study. Data showed that 93.8% of MDR E. coli and 94.5% of MDR K. pneumoniae carried at least one of armA or rmtB . The armA and rmtB genes were present in 11.6% and 82.1% of MDR E. coli , respectively. In parallel, 58.2% and 40.0% of MDR K. pneumoniae were armA - and rmtB -positive, respectively. Furthermore, the qepA gene was present in 66.3% of rmtB -carrying MDR E. coli , but it was rarely detected in MDR K. pneumoniae . Approximately 71.9% of armA -positive MDR K. pneumoniae simultaneously co-carried qnrB and blaDHA . Moreover, 78.1% and 63.6%, respectively, of armA -positive and rmtB -positive MDR K. pneumoniae strains harboured qnr alleles and 53.1% and 59.1% harboured aac(6 ′ )-Ib-cr . In addition, MDR E. coli strains exhibited a low prevalence of qnr alleles and aac(6 ′ )-Ib-cr . PFGE analysis revealed divergent genetic relatedness, suggesting horizontal dissemination of armA and rmtB along with common β-lactamases and PMQR determinants amongst clinical MDR E. coli and K. pneumoniae isolates.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>21724374</pmid><doi>10.1016/j.ijantimicag.2011.04.021</doi><tpages>4</tpages></addata></record> |
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| subjects | 16S rRNA methylase alleles amikacin Antibiotics. Antiinfectious agents. Antiparasitic agents beta-lactamase beta-Lactamases - genetics beta-Lactamases - isolation & purification Biological and medical sciences cefotaxime ciprofloxacin Conjugation, Genetic - physiology DNA, Bacterial - analysis Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - genetics Drug Resistance, Multiple, Bacterial - genetics Escherichia coli Escherichia coli - enzymology Escherichia coli - genetics Escherichia coli - isolation & purification Escherichia coli Proteins - genetics genetic relationships Humans Infectious Disease Klebsiella pneumoniae Klebsiella pneumoniae - enzymology Klebsiella pneumoniae - genetics Klebsiella pneumoniae - isolation & purification Medical sciences Methyltransferases - genetics Microbial Sensitivity Tests Multidrug-resistant multiple drug resistance Pharmacology. Drug treatments phenotype plasmids Plasmids - metabolism polymerase chain reaction Prevalence pulsed-field gel electrophoresis RNA, Ribosomal, 16S - metabolism |
| title | Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates |
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