Antiplatelet Activity of Obovatol, a Biphenolic Component of Magnolia Obovata, in Rat Arterial Thrombosis and Rabbit Platelet Aggregation

Aim: Thrombosis occurs in the coronary arteries via the activation of platelets, and leads to acute myocardial infarction and sudden death. Obovatol, a major biphenolic component of Magnolia Obovata leaves, displays anti-inflammatory and acyl Co-A cholesterol acyltrasferase inhibitory effects. The p...

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Veröffentlicht in:	Journal of Atherosclerosis and Thrombosis 2011, Vol.18(8), pp.659-669
Hauptverfasser:	Park, Eun-Seok, Lim, Yong, Lee, Seung-Ho, Kwon, Byoung-Mog, Yoo, Hwan-Soo, Hong, Jin-Tae, Yun, Yeo-Pyo
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Antiplatelet activity Arteries - pathology Biphenyl Compounds - pharmacology Calcium - metabolism Disease Models, Animal FeCl3-induced thrombosis model Humans Inhibitory Concentration 50 Magnolia - metabolism Male Obovatol Phenol - chemistry Phenyl Ethers - pharmacology Phospholipase C gamma - metabolism Phosphorylation Plant Extracts - pharmacology Platelet Aggregation - drug effects PLC-γ2 Rabbits Rats Rats, Sprague-Dawley Thrombosis Thrombosis - drug therapy
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