Production of anticancer polyenes through precursor-directed biosynthesis

The biosynthesis of the pyrrolyl moiety of the fungal metabolite rumbrin originates from pyrrole-2-carboxylic acid. In an effort to produce novel derivatives with enhanced biological activity a series of substituted pyrrole-2-carboxylates were synthesised and incubated with the producing organism, A...

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Veröffentlicht in:	Organic & biomolecular chemistry 2011-01, Vol.9 (18), p.6306-6311
Hauptverfasser:	Clark, Benjamin R, O'Connor, Stephen, Fox, Deirdre, Leroy, Jacques, Murphy, Cormac D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cytotoxicity Fungi - chemistry HeLa Cells Humans Inhibitory Concentration 50 Lung cancer Metabolites Neoplasms - drug therapy polyenes Polyenes - chemistry Polyenes - pharmacology Proline - analogs & derivatives Proline - chemistry Proline - pharmacology Pyrones - chemistry Pyrones - pharmacology Pyrroles - chemistry Pyrroles - pharmacology Tumor cell lines
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