Markers of susceptibility to acute rheumatic fever: the B-cell antigen D8/17 is not robust as a marker in South Africa
Acute rheumatic fever and its chronic sequelae, rheumatic cardiac disease, and neuropsychiatric movement disorders, remain major public health problems in South Africa. Early identification and treatment of streptococcal pharyngitis in susceptible individuals would prevent rheumatic cardiac disease....
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| Veröffentlicht in: | Cardiology in the young 2011-06, Vol.21 (3), p.328-333 |
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| creator | Walker, Kathleen G. Cooper, Margaret McCabe, Karin Hughes, Jane Mathiassen, Wendy Lawrenson, John Wilmshurst, Jo M. |
| description | Acute rheumatic fever and its chronic sequelae, rheumatic cardiac disease, and neuropsychiatric movement disorders, remain major public health problems in South Africa. Early identification and treatment of streptococcal pharyngitis in susceptible individuals would prevent rheumatic cardiac disease. The B-cell antigen D8/17 is a marker of susceptibility to rheumatic fever in some populations.
We assessed the significance of the D8/17 marker in a group of South Africans. Blood was collected from 107 individuals; 40 patients had previous confirmed rheumatic fever, 20 were first-degree relatives, and 47 were controls. The expression of D8/17 in each sample was analysed by flow cytometry. The mean proportion of B-cells that were D8/17 positive was 0.5% in the index cases, 0.47% in their relatives, and 0.27% in the controls. There was a significant difference between the index cases and the controls, p = 0.03, but the mean percentage positive in each group was very low.
Patients with a history of rheumatic fever had statistically increased expression of the D8/17 marker. However, the actual percentages in this observational study were markedly lower than in other populations, ranging from 0.14%-1.53% compared to 11.6%-39.3%. The D8/17 marker would be an impractical screening tool in the South African population. |
| doi_str_mv | 10.1017/S1047951111000035 |
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We assessed the significance of the D8/17 marker in a group of South Africans. Blood was collected from 107 individuals; 40 patients had previous confirmed rheumatic fever, 20 were first-degree relatives, and 47 were controls. The expression of D8/17 in each sample was analysed by flow cytometry. The mean proportion of B-cells that were D8/17 positive was 0.5% in the index cases, 0.47% in their relatives, and 0.27% in the controls. There was a significant difference between the index cases and the controls, p = 0.03, but the mean percentage positive in each group was very low.
Patients with a history of rheumatic fever had statistically increased expression of the D8/17 marker. However, the actual percentages in this observational study were markedly lower than in other populations, ranging from 0.14%-1.53% compared to 11.6%-39.3%. The D8/17 marker would be an impractical screening tool in the South African population.</description><identifier>ISSN: 1047-9511</identifier><identifier>EISSN: 1467-1107</identifier><identifier>DOI: 10.1017/S1047951111000035</identifier><identifier>PMID: 21303578</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Antibodies, Monoclonal ; Biomarkers - blood ; Case-Control Studies ; Colleges & universities ; Family medical history ; Female ; Fever ; Flow Cytometry ; Humans ; Isoantigens - blood ; Male ; Rheumatic fever ; Rheumatic Fever - blood ; South Africa</subject><ispartof>Cardiology in the young, 2011-06, Vol.21 (3), p.328-333</ispartof><rights>Copyright © Cambridge University Press 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-ef9318602d420cfb4c21c048031f7c22a53acddffc607f6435d27a6114095d913</citedby><cites>FETCH-LOGICAL-c371t-ef9318602d420cfb4c21c048031f7c22a53acddffc607f6435d27a6114095d913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S1047951111000035/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27901,27902,55603</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21303578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walker, Kathleen G.</creatorcontrib><creatorcontrib>Cooper, Margaret</creatorcontrib><creatorcontrib>McCabe, Karin</creatorcontrib><creatorcontrib>Hughes, Jane</creatorcontrib><creatorcontrib>Mathiassen, Wendy</creatorcontrib><creatorcontrib>Lawrenson, John</creatorcontrib><creatorcontrib>Wilmshurst, Jo M.</creatorcontrib><title>Markers of susceptibility to acute rheumatic fever: the B-cell antigen D8/17 is not robust as a marker in South Africa</title><title>Cardiology in the young</title><addtitle>Cardiol Young</addtitle><description>Acute rheumatic fever and its chronic sequelae, rheumatic cardiac disease, and neuropsychiatric movement disorders, remain major public health problems in South Africa. Early identification and treatment of streptococcal pharyngitis in susceptible individuals would prevent rheumatic cardiac disease. The B-cell antigen D8/17 is a marker of susceptibility to rheumatic fever in some populations.
We assessed the significance of the D8/17 marker in a group of South Africans. Blood was collected from 107 individuals; 40 patients had previous confirmed rheumatic fever, 20 were first-degree relatives, and 47 were controls. The expression of D8/17 in each sample was analysed by flow cytometry. The mean proportion of B-cells that were D8/17 positive was 0.5% in the index cases, 0.47% in their relatives, and 0.27% in the controls. There was a significant difference between the index cases and the controls, p = 0.03, but the mean percentage positive in each group was very low.
Patients with a history of rheumatic fever had statistically increased expression of the D8/17 marker. However, the actual percentages in this observational study were markedly lower than in other populations, ranging from 0.14%-1.53% compared to 11.6%-39.3%. The D8/17 marker would be an impractical screening tool in the South African population.</description><subject>Antibodies, Monoclonal</subject><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Colleges & universities</subject><subject>Family medical history</subject><subject>Female</subject><subject>Fever</subject><subject>Flow Cytometry</subject><subject>Humans</subject><subject>Isoantigens - blood</subject><subject>Male</subject><subject>Rheumatic fever</subject><subject>Rheumatic Fever - blood</subject><subject>South Africa</subject><issn>1047-9511</issn><issn>1467-1107</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1P3DAQhq0KVGDLD-ilGnHpKeCJ4zjhRvmWQBwo58hxbNawibf-QOLf44VtkaiYy4w17zwz1kvId6T7SFEc3CKtRMsxB83B-BeyjVUtivwWG7nO7WLV3yI7ITxQiowh_Uq2SmRZLZpt8nQt_aP2AZyBkILSy2h7u7DxGaIDqVLU4Oc6jTJaBUY_aX8Ica7hV6H0YgFyivZeT3DSHKAAG2ByEbzrU4ggA0gYX_lgJ7h1Kc7hyHir5DeyaeQi6N11npG7s9PfxxfF1c355fHRVaGYwFho0zJsaloOVUmV6StVoqJVQxkaocpScibVMBijaipMXTE-lELWiBVt-dAim5Gfb9yld3-SDrEbbVgdLiftUuiahvOatSXPyr0PygeX_JSP65qatxVvM35G8E2kvAvBa9Mtvc0_fO6QditLuv8syTM_1uDUj3r4N_HXgyxga6gce2-He_2--nPsC9UVk58</recordid><startdate>201106</startdate><enddate>201106</enddate><creator>Walker, Kathleen G.</creator><creator>Cooper, Margaret</creator><creator>McCabe, Karin</creator><creator>Hughes, Jane</creator><creator>Mathiassen, Wendy</creator><creator>Lawrenson, John</creator><creator>Wilmshurst, Jo M.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7Z</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201106</creationdate><title>Markers of susceptibility to acute rheumatic fever: the B-cell antigen D8/17 is not robust as a marker in South Africa</title><author>Walker, Kathleen G. ; 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Early identification and treatment of streptococcal pharyngitis in susceptible individuals would prevent rheumatic cardiac disease. The B-cell antigen D8/17 is a marker of susceptibility to rheumatic fever in some populations.
We assessed the significance of the D8/17 marker in a group of South Africans. Blood was collected from 107 individuals; 40 patients had previous confirmed rheumatic fever, 20 were first-degree relatives, and 47 were controls. The expression of D8/17 in each sample was analysed by flow cytometry. The mean proportion of B-cells that were D8/17 positive was 0.5% in the index cases, 0.47% in their relatives, and 0.27% in the controls. There was a significant difference between the index cases and the controls, p = 0.03, but the mean percentage positive in each group was very low.
Patients with a history of rheumatic fever had statistically increased expression of the D8/17 marker. However, the actual percentages in this observational study were markedly lower than in other populations, ranging from 0.14%-1.53% compared to 11.6%-39.3%. The D8/17 marker would be an impractical screening tool in the South African population.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>21303578</pmid><doi>10.1017/S1047951111000035</doi><tpages>6</tpages></addata></record> |
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| subjects | Antibodies, Monoclonal Biomarkers - blood Case-Control Studies Colleges & universities Family medical history Female Fever Flow Cytometry Humans Isoantigens - blood Male Rheumatic fever Rheumatic Fever - blood South Africa |
| title | Markers of susceptibility to acute rheumatic fever: the B-cell antigen D8/17 is not robust as a marker in South Africa |
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