HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities

Cryptococcus neoformans causes life-threatening meningoencephalitis, particularly prevalent in AIDS patients. The interrelationship between C. neoformans and HIV-1 is intriguing, as both pathogens elicit severe neuropathological complications. We have previously demonstrated that the HIV-1 gp41 ecto...

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Veröffentlicht in:	Biochemical journal 2011-09, Vol.438 (3), p.457-466
Hauptverfasser:	Huang, Sheng-He, Wu, Chu-Hua, Jiang, Shibo, Bahner, Ingrid, Lossinsky, Albert S, Jong, Ambrose Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Binding Sites Brain - blood supply Brain - metabolism Brain - microbiology Cell Membrane - metabolism Cell Membrane - microbiology Cells, Cultured Cryptococcosis - metabolism Cryptococcus neoformans - physiology Endothelial Cells - metabolism Endothelial Cells - microbiology Endothelium, Vascular - cytology Endothelium, Vascular - microbiology HIV Envelope Protein gp41 - chemistry HIV Envelope Protein gp41 - genetics HIV Envelope Protein gp41 - metabolism HIV-1 - metabolism Humans Intercellular Adhesion Molecule-1 - genetics Intercellular Adhesion Molecule-1 - metabolism Microscopy, Electron, Transmission Microscopy, Fluorescence Mutation Protein Kinase C-alpha - metabolism
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