Myocardial Protective Effect of Human Atrial Natriuretic Peptide in Cardiac Surgery: "hANP Shot" in Clinical Safety Trial

Background: We studied low-dose human atrial natriuretic peptide (hANP) infusion therapy during cardiac surgery and reported the cardiac and renal protective effects. The efficacy of a bolus injection of hANP (the "hANP shot") simultaneously with induction of cardioplegia has been proven i...

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Veröffentlicht in:	Circulation Journal 2011, Vol.75(9), pp.2144-2150
Hauptverfasser:	Sezai, Akira, Wakui, Shinji, Akiyama, Kenji, Hata, Mitsumasa, Yoshitake, Isamu, Unosawa, Satoshi, Shiono, Motomi, Hirayama, Atsushi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aldosterone - blood Angiotensin II - blood Arrhythmias, Cardiac - blood Arrhythmias, Cardiac - etiology Arrhythmias, Cardiac - prevention & control Atrial Natriuretic Factor - administration & dosage Atrial Natriuretic Factor - adverse effects Atrial natriuretic peptide Cardiotonic Agents - administration & dosage Cardiotonic Agents - adverse effects Coronary Artery Bypass Coronary artery bypass grafts surgery Creatine Kinase, MB Form - blood Cyclic GMP - blood Dose-Response Relationship, Drug Fatty Acid Binding Protein 3 Fatty Acid-Binding Proteins - blood Female Heart Arrest, Induced Humans Male Middle Aged Natriuretic Peptide, Brain - blood Natriuretic peptides Postoperative Complications - blood Postoperative Complications - prevention & control Renin - blood Troponin I - blood
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