Differential effects of esculetin and daphnetin on in vitro cell proliferation and in vivo estrogenicity

Esculetin (6,7-dihydroxycoumarin) and daphnetin (7,8-dihydroxycoumarin) are secondary metabolites of plants used in folk medicine. These compounds have showed great antiproliferative activity in several tumor cell lines and have been proposed as potential anticancer agents. However, the estrogenic p...

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Veröffentlicht in:	European journal of pharmacology 2011-10, Vol.668 (1-2), p.35-41
Hauptverfasser:	Jiménez-Orozco, Fausto Alejandro, Rosales, Ana Alejandra Román, Vega-López, Armando, Domínguez-López, Maria Lilia, García-Mondragón, Ma. Juana, Maldonado-Espinoza, Amelia, Lemini, Cristina, Mendoza-Patiño, Nicandro, Mandoki, Juan José
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antineoplastic agents Antiproliferative effect Biological and medical sciences carcinoma cell cycle Cell Cycle Proteins - metabolism Cell Line, Tumor cell proliferation Cell Proliferation - drug effects Coumarin Cyclin D1 Daphnetin Esculetin estrogenic properties Estrogenicity Estrogens - pharmacology Female Flow Cytometry gene expression Humans Medical sciences Mice Organ Size - drug effects Pharmacology. Drug treatments postmenopause secondary metabolites therapeutics traditional medicine Umbelliferones - pharmacology Uterus - growth & development
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