Genotoxicity of the copper antineoplastic coordination complexes casiopeinas

► Four different casiopeinas were studied to determinate if they are actual genotoxins. ► The main mechanism of action of these compounds seems to be through ROS generation. ► The results suggest that casiopeinas produce DNA damage and trigger apoptosis. Casiopeinas is the generic name of a group of...

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Veröffentlicht in:	Toxicology in vitro 2011-10, Vol.25 (7), p.1376-1384
Hauptverfasser:	Serment-Guerrero, J., Cano-Sanchez, P., Reyes-Perez, E., Velazquez-Garcia, F., Bravo-Gomez, M.E., Ruiz-Azuara, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Casiopeinas Comet Assay Copper - chemistry Copper - toxicity Copper chelates DNA Fragmentation - drug effects DNA Repair HeLa Cells Humans Lymphocytes - drug effects Mice Models, Molecular Molecular Structure Mutagenicity Tests Organometallic Compounds - chemistry Organometallic Compounds - toxicity Oxidation-Reduction Plasmids ROS Structure-Activity Relationship
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