Genotoxicity of the copper antineoplastic coordination complexes casiopeinas
► Four different casiopeinas were studied to determinate if they are actual genotoxins. ► The main mechanism of action of these compounds seems to be through ROS generation. ► The results suggest that casiopeinas produce DNA damage and trigger apoptosis. Casiopeinas is the generic name of a group of...
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| Veröffentlicht in: | Toxicology in vitro 2011-10, Vol.25 (7), p.1376-1384 |
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| container_title | Toxicology in vitro |
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| creator | Serment-Guerrero, J. Cano-Sanchez, P. Reyes-Perez, E. Velazquez-Garcia, F. Bravo-Gomez, M.E. Ruiz-Azuara, L. |
| description | ► Four different casiopeinas were studied to determinate if they are actual genotoxins. ► The main mechanism of action of these compounds seems to be through ROS generation. ► The results suggest that casiopeinas produce DNA damage and trigger apoptosis.
Casiopeinas is the generic name of a group of coordination complexes with a central copper atom bound to organic ligands, designed to be an alternative to cancer therapy. Indeed, some of these compounds can reduce implanted tumors in mice. Casiopeinas were expressly designed to interact with the genetic material, so the aim of the present work is to determine if these compounds have genotoxic activity. The results indicate that casiopeinas produce DNA fragmentation and base oxidation and suggest that their mode of action is related to reactive oxygen species (ROS) generation after copper reduction. |
| doi_str_mv | 10.1016/j.tiv.2011.05.008 |
| format | Article |
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Casiopeinas is the generic name of a group of coordination complexes with a central copper atom bound to organic ligands, designed to be an alternative to cancer therapy. Indeed, some of these compounds can reduce implanted tumors in mice. Casiopeinas were expressly designed to interact with the genetic material, so the aim of the present work is to determine if these compounds have genotoxic activity. The results indicate that casiopeinas produce DNA fragmentation and base oxidation and suggest that their mode of action is related to reactive oxygen species (ROS) generation after copper reduction.</description><subject>Animals</subject><subject>Antineoplastic</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Casiopeinas</subject><subject>Comet Assay</subject><subject>Copper - chemistry</subject><subject>Copper - toxicity</subject><subject>Copper chelates</subject><subject>DNA Fragmentation - drug effects</subject><subject>DNA Repair</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Lymphocytes - drug effects</subject><subject>Mice</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Mutagenicity Tests</subject><subject>Organometallic Compounds - chemistry</subject><subject>Organometallic Compounds - toxicity</subject><subject>Oxidation-Reduction</subject><subject>Plasmids</subject><subject>ROS</subject><subject>Structure-Activity Relationship</subject><issn>0887-2333</issn><issn>1879-3177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kDFPwzAQhS0EglL4ASwoG1PC2bEdV0wIQUGqxAKz5TgX4SqNg-0i-Pe4KjAyne7uvae7j5ALChUFKq_XVXIfFQNKKxAVgDogM6qaRVnTpjkkM1CqKVld1yfkNMY1AAjF4JicMCqzv2Yzslri6JP_dNalr8L3RXrDwvppwlCYMbkR_TSYmJzNUx86N5rk_JibzTTgJ8bCmuj8hHkRz8hRb4aI5z91Tl4f7l_uHsvV8_Lp7nZVWi5lKhuhVD6Ng6KtaBGUoTVTklHW9RzNAmTLF9Ki4oJTZTsE3nNGzQKhBVS0npOrfe4U_PsWY9IbFy0Og8nnbqNWSggJXIqspHulDT7GgL2egtuY8KUp6B1DvdaZod4x1CB0Zpg9lz_p23aD3Z_jF1oW3OwFmH_8cBh0tA5Hi50LaJPuvPsn_hvC64JB</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Serment-Guerrero, J.</creator><creator>Cano-Sanchez, P.</creator><creator>Reyes-Perez, E.</creator><creator>Velazquez-Garcia, F.</creator><creator>Bravo-Gomez, M.E.</creator><creator>Ruiz-Azuara, L.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201110</creationdate><title>Genotoxicity of the copper antineoplastic coordination complexes casiopeinas</title><author>Serment-Guerrero, J. ; Cano-Sanchez, P. ; Reyes-Perez, E. ; Velazquez-Garcia, F. ; Bravo-Gomez, M.E. ; Ruiz-Azuara, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-75880884081b5be08a13286212df4ea906b496ce845418cde04f421a9e0b0e813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antineoplastic</topic><topic>Antineoplastic Agents - chemistry</topic><topic>Antineoplastic Agents - toxicity</topic><topic>Casiopeinas</topic><topic>Comet Assay</topic><topic>Copper - chemistry</topic><topic>Copper - toxicity</topic><topic>Copper chelates</topic><topic>DNA Fragmentation - drug effects</topic><topic>DNA Repair</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Lymphocytes - drug effects</topic><topic>Mice</topic><topic>Models, Molecular</topic><topic>Molecular Structure</topic><topic>Mutagenicity Tests</topic><topic>Organometallic Compounds - chemistry</topic><topic>Organometallic Compounds - toxicity</topic><topic>Oxidation-Reduction</topic><topic>Plasmids</topic><topic>ROS</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Serment-Guerrero, J.</creatorcontrib><creatorcontrib>Cano-Sanchez, P.</creatorcontrib><creatorcontrib>Reyes-Perez, E.</creatorcontrib><creatorcontrib>Velazquez-Garcia, F.</creatorcontrib><creatorcontrib>Bravo-Gomez, M.E.</creatorcontrib><creatorcontrib>Ruiz-Azuara, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Toxicology in vitro</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Serment-Guerrero, J.</au><au>Cano-Sanchez, P.</au><au>Reyes-Perez, E.</au><au>Velazquez-Garcia, F.</au><au>Bravo-Gomez, M.E.</au><au>Ruiz-Azuara, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genotoxicity of the copper antineoplastic coordination complexes casiopeinas</atitle><jtitle>Toxicology in vitro</jtitle><addtitle>Toxicol In Vitro</addtitle><date>2011-10</date><risdate>2011</risdate><volume>25</volume><issue>7</issue><spage>1376</spage><epage>1384</epage><pages>1376-1384</pages><issn>0887-2333</issn><eissn>1879-3177</eissn><abstract>► Four different casiopeinas were studied to determinate if they are actual genotoxins. ► The main mechanism of action of these compounds seems to be through ROS generation. ► The results suggest that casiopeinas produce DNA damage and trigger apoptosis.
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antineoplastic Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Casiopeinas Comet Assay Copper - chemistry Copper - toxicity Copper chelates DNA Fragmentation - drug effects DNA Repair HeLa Cells Humans Lymphocytes - drug effects Mice Models, Molecular Molecular Structure Mutagenicity Tests Organometallic Compounds - chemistry Organometallic Compounds - toxicity Oxidation-Reduction Plasmids ROS Structure-Activity Relationship |
| title | Genotoxicity of the copper antineoplastic coordination complexes casiopeinas |
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