Knock-Out of the Potassium Channel TASK-1 Leads to a Prolonged QT Interval and a Disturbed QRS Complex

Background/Aims: The aim of the study was to characterize the whole cell current of the two-pore domain potassium channel TASK-1 (K2P3) in mouse ventricular cardiomyocytes (I TASK-1 ) and to analyze the cardiac phenotype of the TASK-1 -/- mice. Methods and Results: We have quantified the ventricular...

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Veröffentlicht in:	Cellular physiology and biochemistry 2011-01, Vol.28 (1), p.77-86
Hauptverfasser:	Decher, Niels, Wemhöner, Konstantin, Rinné, Susanne, Netter, Michael F., Zuzarte, Marylou, Aller, Maria I., Kaufmann, Susann G., Li, Xian Tao, Meuth, Sven G., Daut, Jürgen, Sachse, Frank B., Maier, Sebastian K.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Anesthetics, Inhalation - pharmacology Animals Electrophysiological Phenomena - physiology Heart Rate - drug effects Hemodynamics - physiology Isoflurane - pharmacology Long QT Syndrome - etiology Methoxamine - pharmacology Mice Mice, Knockout Myocytes, Cardiac - drug effects Myocytes, Cardiac - physiology Nerve Tissue Proteins - deficiency Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Original Paper ortho-Aminobenzoates - pharmacology Potassium Channels, Tandem Pore Domain - deficiency Potassium Channels, Tandem Pore Domain - genetics Potassium Channels, Tandem Pore Domain - metabolism Sulfonamides - pharmacology
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