Reticulin fibres anchor leukaemic blasts in the marrow of patients with acute lymphoblastic leukaemia

Abstract Reticulin fibrosis has been recognized in childhood ALL at diagnosis as part of the altered stromal structure in the bone marrow (BM). Increased fibre density is correlated with a higher concentration of leukaemia cells in the BM and lower numbers of blasts in peripheral blood. We hypothesi...

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Veröffentlicht in:	Medical hypotheses 2011-09, Vol.77 (3), p.333-335
Hauptverfasser:	Nath, Shriram V, Nicholson, Ian, Tapp, Heather, Zola, Heddy, Zannettino, Andrew C.W, Revesz, Tamas
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cytokines - metabolism Fibrosis - metabolism Humans Intercellular Signaling Peptides and Proteins - metabolism Internal Medicine Lymphocyte Count Precursor Cell Lymphoblastic Leukemia-Lymphoma - metabolism Reticulin - metabolism Stromal Cells - metabolism
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