Acute Disruption of Leptin Signaling in Vivo Leads to Increased Insulin Levels and Insulin Resistance

Leptin, an adipocyte-derived hormone, plays an essential role in the maintenance of normal body weight and energy expenditure, as well as glucose homeostasis. Indeed, leptin-deficient ob/ob mice are obese with profound hyperinsulinemia, insulin resistance, and often hyperglycemia. Interestingly, low...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-09, Vol.152 (9), p.3385-3395
Hauptverfasser:	Levi, Jasna, Gray, Sarah L, Speck, Madeleine, Huynh, Frank K, Babich, Sandra L, Gibson, William T, Kieffer, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Beta cells Biological and medical sciences Body composition Body weight Calorimetry, Indirect Cholesterol - metabolism Disruption Energy expenditure Energy Metabolism - physiology Fasting - metabolism Food composition Food intake Fundamental and applied biological sciences. Psychology Glucose Glucose - metabolism Glucose Clamp Technique Homeostasis Hyperglycemia Hyperinsulinemia Infusion Pumps, Implantable Insulin Insulin - blood Insulin resistance Insulin Resistance - physiology Leptin Leptin - antagonists & inhibitors Leptin - metabolism Lipids Liver Liver - metabolism Male Mice Obesity Parameter sensitivity Polyethylene glycol Respiratory quotient Sensitivity analysis Signal Transduction - physiology Triglycerides - metabolism Vertebrates: endocrinology
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