Increased Bone Formation and Bone Mass Induced by Sclerostin Antibody Is Not Affected by Pretreatment or Cotreatment with Alendronate in Osteopenic, Ovariectomized Rats

Clinical studies have revealed a blunting of the bone anabolic effects of parathyroid hormone treatment in osteoporotic patients in the setting of pre- or cotreatment with the antiresorptive agent alendronate (ALN). Sclerostin monoclonal antibody (Scl-Ab) is currently under clinical investigation as...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2011-09, Vol.152 (9), p.3312-3322
Hauptverfasser:	Li, Xiaodong, Ominsky, Michael S, Warmington, Kelly S, Niu, Qing-Tian, Asuncion, Franklin J, Barrero, Mauricio, Dwyer, Denise, Grisanti, Mario, Stolina, Marina, Kostenuik, Paul J, Simonet, William S, Paszty, Chris, Ke, Hua Zhu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acid Phosphatase - blood Alendronate - pharmacology Alendronate - therapeutic use Alendronic acid Animals Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Biological and medical sciences Bisphosphonates Bone and Bones - drug effects Bone and Bones - immunology Bone density Bone Density - drug effects Bone Density - immunology Bone Density Conservation Agents - pharmacology Bone Density Conservation Agents - therapeutic use Bone Diseases, Metabolic - blood Bone Diseases, Metabolic - drug therapy Bone Diseases, Metabolic - immunology Bone growth Bone mass Bone mineral density Bone Morphogenetic Proteins - immunology Bone strength Cancellous bone Cortical bone Disease Models, Animal Diseases of the osteoarticular system Female Fundamental and applied biological sciences. Psychology Genetic Markers - immunology Isoenzymes - blood Medical sciences Menopause Monoclonal antibodies Osteocalcin Osteocalcin - blood Osteogenesis Osteogenesis - drug effects Osteogenesis - immunology Osteopenia Osteoporosis Osteoporosis. Osteomalacia. Paget disease Ovariectomy Parathyroid hormone Post-menopause Pretreatment Rats Rats, Sprague-Dawley SOST protein Tartrate-Resistant Acid Phosphatase Vertebrates: endocrinology
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