The n-butanolic extract of Opuntia ficus-indica var. saboten enhances long-term memory in the passive avoidance task in mice
Opuntia ficus-indica var. saboten Makino (Cactaceae) is used to treat burns, edema, dyspepsia, and asthma in traditional medicine. The present study investigated the beneficial effects of the n-butanolic extract of O. ficus-indica var. saboten (BOF) on memory performance in mice and attempts to unco...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2010-08, Vol.34 (6), p.1011-1017 |
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| creator | Kim, Jong Min Kim, Dong Hyun Park, Se Jin Park, Dong Hyun Jung, Seo Yun Kim, Hyoung Ja Lee, Yong Sup Jin, Changbae Ryu, Jong Hoon |
| description | Opuntia ficus-indica var.
saboten Makino (Cactaceae) is used to treat burns, edema, dyspepsia, and asthma in traditional medicine. The present study investigated the beneficial effects of the
n-butanolic extract of
O. ficus-indica var.
saboten (BOF) on memory performance in mice and attempts to uncover the mechanisms underlying its action. Memory performance was assessed with the passive avoidance task, and western blotting and immunohistochemistry were used to measure changes in protein expression and cell survival. After the oral administration of BOF for 7
days, the latency time in the passive avoidance task was significantly increased relative to vehicle-treated controls (
P
<
0.05). Western blotting revealed that the expression levels of brain-derived neurotrophic factor (BDNF), phosphorylated cAMP response element binding-protein (pCREB), and phosphorylated extracellular signal-regulated kinase (pERK) 1/2 were significantly increased in hippocampal tissue after 7
days of BOF administration (
P
<
0.05). Doublecortin and 5-bromo-2-deoxyuridine immunostaining also revealed that BOF significantly enhanced the survival of immature neurons, but did not affect neuronal cell proliferation in the subgranular zone of the hippocampal dentate gyrus. These results suggest that the subchronic administration of BOF enhances long-term memory, and that this effect is partially mediated by ERK-CREB-BDNF signaling and the survival of immature neurons. |
| doi_str_mv | 10.1016/j.pnpbp.2010.05.015 |
| format | Article |
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saboten Makino (Cactaceae) is used to treat burns, edema, dyspepsia, and asthma in traditional medicine. The present study investigated the beneficial effects of the
n-butanolic extract of
O. ficus-indica var.
saboten (BOF) on memory performance in mice and attempts to uncover the mechanisms underlying its action. Memory performance was assessed with the passive avoidance task, and western blotting and immunohistochemistry were used to measure changes in protein expression and cell survival. After the oral administration of BOF for 7
days, the latency time in the passive avoidance task was significantly increased relative to vehicle-treated controls (
P
<
0.05). Western blotting revealed that the expression levels of brain-derived neurotrophic factor (BDNF), phosphorylated cAMP response element binding-protein (pCREB), and phosphorylated extracellular signal-regulated kinase (pERK) 1/2 were significantly increased in hippocampal tissue after 7
days of BOF administration (
P
<
0.05). Doublecortin and 5-bromo-2-deoxyuridine immunostaining also revealed that BOF significantly enhanced the survival of immature neurons, but did not affect neuronal cell proliferation in the subgranular zone of the hippocampal dentate gyrus. These results suggest that the subchronic administration of BOF enhances long-term memory, and that this effect is partially mediated by ERK-CREB-BDNF signaling and the survival of immature neurons.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2010.05.015</identifier><identifier>PMID: 20493231</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Avoidance Learning - drug effects ; BDNF ; Biological and medical sciences ; Blotting, Western ; Brain-Derived Neurotrophic Factor - metabolism ; Cactaceae ; Cyclic AMP Response Element-Binding Protein - metabolism ; General pharmacology ; Hippocampus - drug effects ; Hippocampus - metabolism ; Immunohistochemistry ; Long-term memory ; Male ; Medical sciences ; Memory - drug effects ; Mice ; Mitogen-Activated Protein Kinase 1 - metabolism ; Mitogen-Activated Protein Kinase 3 - metabolism ; Neurogenesis ; Neurogenesis - drug effects ; Neurons - drug effects ; Neurons - metabolism ; Opuntia ; Opuntia ficus-indica ; Opuntia ficus-indica var. saboten ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phosphorylation - drug effects ; Plant Extracts - pharmacology ; Plant Stems ; Signal Transduction - drug effects</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2010-08, Vol.34 (6), p.1011-1017</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-b8cb5138d4f8b9185b0e78c298f5d95a84823684ca435c8caa87cf1cc3f84e473</citedby><cites>FETCH-LOGICAL-c486t-b8cb5138d4f8b9185b0e78c298f5d95a84823684ca435c8caa87cf1cc3f84e473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2010.05.015$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23116727$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20493231$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jong Min</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>Park, Se Jin</creatorcontrib><creatorcontrib>Park, Dong Hyun</creatorcontrib><creatorcontrib>Jung, Seo Yun</creatorcontrib><creatorcontrib>Kim, Hyoung Ja</creatorcontrib><creatorcontrib>Lee, Yong Sup</creatorcontrib><creatorcontrib>Jin, Changbae</creatorcontrib><creatorcontrib>Ryu, Jong Hoon</creatorcontrib><title>The n-butanolic extract of Opuntia ficus-indica var. saboten enhances long-term memory in the passive avoidance task in mice</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Opuntia ficus-indica var.
saboten Makino (Cactaceae) is used to treat burns, edema, dyspepsia, and asthma in traditional medicine. The present study investigated the beneficial effects of the
n-butanolic extract of
O. ficus-indica var.
saboten (BOF) on memory performance in mice and attempts to uncover the mechanisms underlying its action. Memory performance was assessed with the passive avoidance task, and western blotting and immunohistochemistry were used to measure changes in protein expression and cell survival. After the oral administration of BOF for 7
days, the latency time in the passive avoidance task was significantly increased relative to vehicle-treated controls (
P
<
0.05). Western blotting revealed that the expression levels of brain-derived neurotrophic factor (BDNF), phosphorylated cAMP response element binding-protein (pCREB), and phosphorylated extracellular signal-regulated kinase (pERK) 1/2 were significantly increased in hippocampal tissue after 7
days of BOF administration (
P
<
0.05). Doublecortin and 5-bromo-2-deoxyuridine immunostaining also revealed that BOF significantly enhanced the survival of immature neurons, but did not affect neuronal cell proliferation in the subgranular zone of the hippocampal dentate gyrus. These results suggest that the subchronic administration of BOF enhances long-term memory, and that this effect is partially mediated by ERK-CREB-BDNF signaling and the survival of immature neurons.</description><subject>Animals</subject><subject>Avoidance Learning - drug effects</subject><subject>BDNF</subject><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Brain-Derived Neurotrophic Factor - metabolism</subject><subject>Cactaceae</subject><subject>Cyclic AMP Response Element-Binding Protein - metabolism</subject><subject>General pharmacology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Immunohistochemistry</subject><subject>Long-term memory</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - drug effects</subject><subject>Mice</subject><subject>Mitogen-Activated Protein Kinase 1 - metabolism</subject><subject>Mitogen-Activated Protein Kinase 3 - metabolism</subject><subject>Neurogenesis</subject><subject>Neurogenesis - drug effects</subject><subject>Neurons - drug effects</subject><subject>Neurons - metabolism</subject><subject>Opuntia</subject><subject>Opuntia ficus-indica</subject><subject>Opuntia ficus-indica var. saboten</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphorylation - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Stems</subject><subject>Signal Transduction - drug effects</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2L1TAUhoMoznX0FwiSjbjqNZ9tunAhg18wMJtxHdLTUyfXNqlJenHAH2_rvepOVwnJc96E9yHkOWd7znj9-rCfw9zNe8HWE6b3jOsHZMdNYyoleP2Q7JhY99qo-oI8yfnAGOOSycfkQjDVSiH5jvy4vUMaqm4pLsTRA8XvJTkoNA70Zl5C8Y4OHpZc-dB7cPTo0p5m18WCgWK4cwEw0zGGL1XBNNEJp5juqQ-0rMmzy9kfkbpj9P2G0uLy1-128oBPyaPBjRmfnddL8vn9u9urj9X1zYdPV2-vK1CmLlVnoNNcml4Npmu50R3DxoBozaD7VjujjJC1UeCU1GDAOdPAwAHkYBSqRl6SV6fcOcVvC-ZiJ58Bx9EFjEu2xmimRSPUf8lGtYy3bbNlyhMJKeaccLBz8pNL95Yzu_mxB_vLj938WKbt6medenHOX7oJ-z8zv4WswMsz4DK4cUhraT7_5STndSO259-cOFx7O3pMNoPHteDeJ4Ri--j_-ZGfB-GwGQ</recordid><startdate>20100816</startdate><enddate>20100816</enddate><creator>Kim, Jong Min</creator><creator>Kim, Dong Hyun</creator><creator>Park, Se Jin</creator><creator>Park, Dong Hyun</creator><creator>Jung, Seo Yun</creator><creator>Kim, Hyoung Ja</creator><creator>Lee, Yong Sup</creator><creator>Jin, Changbae</creator><creator>Ryu, Jong Hoon</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20100816</creationdate><title>The n-butanolic extract of Opuntia ficus-indica var. saboten enhances long-term memory in the passive avoidance task in mice</title><author>Kim, Jong Min ; Kim, Dong Hyun ; Park, Se Jin ; Park, Dong Hyun ; Jung, Seo Yun ; Kim, Hyoung Ja ; Lee, Yong Sup ; Jin, Changbae ; Ryu, Jong Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-b8cb5138d4f8b9185b0e78c298f5d95a84823684ca435c8caa87cf1cc3f84e473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Avoidance Learning - drug effects</topic><topic>BDNF</topic><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Brain-Derived Neurotrophic Factor - metabolism</topic><topic>Cactaceae</topic><topic>Cyclic AMP Response Element-Binding Protein - metabolism</topic><topic>General pharmacology</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Immunohistochemistry</topic><topic>Long-term memory</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - drug effects</topic><topic>Mice</topic><topic>Mitogen-Activated Protein Kinase 1 - metabolism</topic><topic>Mitogen-Activated Protein Kinase 3 - metabolism</topic><topic>Neurogenesis</topic><topic>Neurogenesis - drug effects</topic><topic>Neurons - drug effects</topic><topic>Neurons - metabolism</topic><topic>Opuntia</topic><topic>Opuntia ficus-indica</topic><topic>Opuntia ficus-indica var. saboten</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Phosphorylation - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Stems</topic><topic>Signal Transduction - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jong Min</creatorcontrib><creatorcontrib>Kim, Dong Hyun</creatorcontrib><creatorcontrib>Park, Se Jin</creatorcontrib><creatorcontrib>Park, Dong Hyun</creatorcontrib><creatorcontrib>Jung, Seo Yun</creatorcontrib><creatorcontrib>Kim, Hyoung Ja</creatorcontrib><creatorcontrib>Lee, Yong Sup</creatorcontrib><creatorcontrib>Jin, Changbae</creatorcontrib><creatorcontrib>Ryu, Jong Hoon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jong Min</au><au>Kim, Dong Hyun</au><au>Park, Se Jin</au><au>Park, Dong Hyun</au><au>Jung, Seo Yun</au><au>Kim, Hyoung Ja</au><au>Lee, Yong Sup</au><au>Jin, Changbae</au><au>Ryu, Jong Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The n-butanolic extract of Opuntia ficus-indica var. saboten enhances long-term memory in the passive avoidance task in mice</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2010-08-16</date><risdate>2010</risdate><volume>34</volume><issue>6</issue><spage>1011</spage><epage>1017</epage><pages>1011-1017</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Opuntia ficus-indica var.
saboten Makino (Cactaceae) is used to treat burns, edema, dyspepsia, and asthma in traditional medicine. The present study investigated the beneficial effects of the
n-butanolic extract of
O. ficus-indica var.
saboten (BOF) on memory performance in mice and attempts to uncover the mechanisms underlying its action. Memory performance was assessed with the passive avoidance task, and western blotting and immunohistochemistry were used to measure changes in protein expression and cell survival. After the oral administration of BOF for 7
days, the latency time in the passive avoidance task was significantly increased relative to vehicle-treated controls (
P
<
0.05). Western blotting revealed that the expression levels of brain-derived neurotrophic factor (BDNF), phosphorylated cAMP response element binding-protein (pCREB), and phosphorylated extracellular signal-regulated kinase (pERK) 1/2 were significantly increased in hippocampal tissue after 7
days of BOF administration (
P
<
0.05). Doublecortin and 5-bromo-2-deoxyuridine immunostaining also revealed that BOF significantly enhanced the survival of immature neurons, but did not affect neuronal cell proliferation in the subgranular zone of the hippocampal dentate gyrus. These results suggest that the subchronic administration of BOF enhances long-term memory, and that this effect is partially mediated by ERK-CREB-BDNF signaling and the survival of immature neurons.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20493231</pmid><doi>10.1016/j.pnpbp.2010.05.015</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Avoidance Learning - drug effects BDNF Biological and medical sciences Blotting, Western Brain-Derived Neurotrophic Factor - metabolism Cactaceae Cyclic AMP Response Element-Binding Protein - metabolism General pharmacology Hippocampus - drug effects Hippocampus - metabolism Immunohistochemistry Long-term memory Male Medical sciences Memory - drug effects Mice Mitogen-Activated Protein Kinase 1 - metabolism Mitogen-Activated Protein Kinase 3 - metabolism Neurogenesis Neurogenesis - drug effects Neurons - drug effects Neurons - metabolism Opuntia Opuntia ficus-indica Opuntia ficus-indica var. saboten Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phosphorylation - drug effects Plant Extracts - pharmacology Plant Stems Signal Transduction - drug effects |
| title | The n-butanolic extract of Opuntia ficus-indica var. saboten enhances long-term memory in the passive avoidance task in mice |
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