Development of a metabolic network design and optimization framework incorporating implementation constraints: A succinate production case study

We have developed a pathway design and optimization scheme that accommodates genetically and/or environmentally derived operational constraints. We express the full set of theoretically optimal pathways in terms of the underlying elementary flux modes and then examine the sensitivity of the optimal...

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Veröffentlicht in:	Metabolic engineering 2006, Vol.8 (1), p.46-57
Hauptverfasser:	Cox, Steven J., Shalel Levanon, Sagit, Sanchez, Ailen, Lin, Henry, Peercy, Brad, Bennett, George N., San, Ka-Yiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Elementary flux mode Escherichia coli Escherichia coli - metabolism Models, Biological Operational constraints Pathway design and optimization Sensitivity Succinate production Succinic Acid - metabolism
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