Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI
Subcortical nuclei are increasingly targeted for deep brain stimulation (DBS) and for gene transfer to treat neurological and psychiatric disorders. For a successful outcome in patients, it is critical to place DBS electrodes or infuse viral vectors accurately within targeted nuclei. However current...
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| Veröffentlicht in: | NeuroImage (Orlando, Fla.) Fla.), 2011-09, Vol.58 (1), p.60-68 |
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| creator | Tani, Naoki Joly, Olivier Iwamuro, Hirokazu Uhrig, Lynn Wiggins, Christopher J. Poupon, Cyril Kolster, Hauke Vanduffel, Wim Le Bihan, Denis Palfi, Stéphane Jarraya, Béchir |
| description | Subcortical nuclei are increasingly targeted for deep brain stimulation (DBS) and for gene transfer to treat neurological and psychiatric disorders. For a successful outcome in patients, it is critical to place DBS electrodes or infuse viral vectors accurately within targeted nuclei. However current MRI approaches are still limited to localize brainstem and basal ganglia nuclei accurately. By combining ultra-high resolution structural MRI and contrast-enhanced MRI using iron oxide nanoparticles at high field (3
T and 7
T), we could precisely locate the subcortical nuclei, in particular the subthalamic nucleus in macaques, and validate this location by intracranial electrophysiological mapping. The present data pave the way to a clinical application.
[Display omitted]
► Identification of the subthalamic nucleus in the non-human primate using MRI at 3T and 7T. ► Contrast enhancement with P904, an ultra-small superparamagnetic iron oxide particle. ► Electrophysiological mapping confirmation of MRI findings. ► Direct visualization of subthalamic nucleus with P904. |
| doi_str_mv | 10.1016/j.neuroimage.2011.06.019 |
| format | Article |
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T and 7
T), we could precisely locate the subcortical nuclei, in particular the subthalamic nucleus in macaques, and validate this location by intracranial electrophysiological mapping. The present data pave the way to a clinical application.
[Display omitted]
► Identification of the subthalamic nucleus in the non-human primate using MRI at 3T and 7T. ► Contrast enhancement with P904, an ultra-small superparamagnetic iron oxide particle. ► Electrophysiological mapping confirmation of MRI findings. ► Direct visualization of subthalamic nucleus with P904.</description><identifier>ISSN: 1053-8119</identifier><identifier>EISSN: 1095-9572</identifier><identifier>DOI: 10.1016/j.neuroimage.2011.06.019</identifier><identifier>PMID: 21704174</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging - physiology ; Algorithms ; Animals ; Basal Ganglia - anatomy & histology ; Basal Ganglia - physiology ; Brain Mapping ; Brain research ; Brain Stem - anatomy & histology ; Brain Stem - physiology ; Contrast agents ; Electrophysiological Phenomena ; Electrophysiology ; Female ; High field ; Image Processing, Computer-Assisted ; Individuality ; Iron oxide ; Laboratory animals ; Macaca ; Macaca mulatta ; Magnetic Resonance Imaging - methods ; Male ; Microelectrodes ; MRI ; Neurosciences ; NMR ; Non human primate ; Nuclear magnetic resonance ; Parkinson's disease ; Patients ; Primates ; Probability ; Quality of life ; Scanners ; Signal-To-Noise Ratio ; Studies ; Subthalamic nucleus ; Subthalamic Nucleus - physiology</subject><ispartof>NeuroImage (Orlando, Fla.), 2011-09, Vol.58 (1), p.60-68</ispartof><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Sep 1, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-9b613d46080de89f90b9666cb5e20705c47ae4ada720f68cc9343cc08f4d1383</citedby><cites>FETCH-LOGICAL-c433t-9b613d46080de89f90b9666cb5e20705c47ae4ada720f68cc9343cc08f4d1383</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1549897043?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21704174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tani, Naoki</creatorcontrib><creatorcontrib>Joly, Olivier</creatorcontrib><creatorcontrib>Iwamuro, Hirokazu</creatorcontrib><creatorcontrib>Uhrig, Lynn</creatorcontrib><creatorcontrib>Wiggins, Christopher J.</creatorcontrib><creatorcontrib>Poupon, Cyril</creatorcontrib><creatorcontrib>Kolster, Hauke</creatorcontrib><creatorcontrib>Vanduffel, Wim</creatorcontrib><creatorcontrib>Le Bihan, Denis</creatorcontrib><creatorcontrib>Palfi, Stéphane</creatorcontrib><creatorcontrib>Jarraya, Béchir</creatorcontrib><title>Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI</title><title>NeuroImage (Orlando, Fla.)</title><addtitle>Neuroimage</addtitle><description>Subcortical nuclei are increasingly targeted for deep brain stimulation (DBS) and for gene transfer to treat neurological and psychiatric disorders. For a successful outcome in patients, it is critical to place DBS electrodes or infuse viral vectors accurately within targeted nuclei. However current MRI approaches are still limited to localize brainstem and basal ganglia nuclei accurately. By combining ultra-high resolution structural MRI and contrast-enhanced MRI using iron oxide nanoparticles at high field (3
T and 7
T), we could precisely locate the subcortical nuclei, in particular the subthalamic nucleus in macaques, and validate this location by intracranial electrophysiological mapping. The present data pave the way to a clinical application.
[Display omitted]
► Identification of the subthalamic nucleus in the non-human primate using MRI at 3T and 7T. ► Contrast enhancement with P904, an ultra-small superparamagnetic iron oxide particle. ► Electrophysiological mapping confirmation of MRI findings. ► Direct visualization of subthalamic nucleus with P904.</description><subject>Aging - physiology</subject><subject>Algorithms</subject><subject>Animals</subject><subject>Basal Ganglia - anatomy & histology</subject><subject>Basal Ganglia - physiology</subject><subject>Brain Mapping</subject><subject>Brain research</subject><subject>Brain Stem - anatomy & histology</subject><subject>Brain Stem - physiology</subject><subject>Contrast agents</subject><subject>Electrophysiological Phenomena</subject><subject>Electrophysiology</subject><subject>Female</subject><subject>High field</subject><subject>Image Processing, Computer-Assisted</subject><subject>Individuality</subject><subject>Iron oxide</subject><subject>Laboratory animals</subject><subject>Macaca</subject><subject>Macaca mulatta</subject><subject>Magnetic Resonance Imaging - 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Academic</collection><collection>Biotechnology Research Abstracts</collection><jtitle>NeuroImage (Orlando, Fla.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tani, Naoki</au><au>Joly, Olivier</au><au>Iwamuro, Hirokazu</au><au>Uhrig, Lynn</au><au>Wiggins, Christopher J.</au><au>Poupon, Cyril</au><au>Kolster, Hauke</au><au>Vanduffel, Wim</au><au>Le Bihan, Denis</au><au>Palfi, Stéphane</au><au>Jarraya, Béchir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI</atitle><jtitle>NeuroImage (Orlando, Fla.)</jtitle><addtitle>Neuroimage</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>58</volume><issue>1</issue><spage>60</spage><epage>68</epage><pages>60-68</pages><issn>1053-8119</issn><eissn>1095-9572</eissn><abstract>Subcortical nuclei are increasingly targeted for deep brain stimulation (DBS) and for gene transfer to treat neurological and psychiatric disorders. For a successful outcome in patients, it is critical to place DBS electrodes or infuse viral vectors accurately within targeted nuclei. However current MRI approaches are still limited to localize brainstem and basal ganglia nuclei accurately. By combining ultra-high resolution structural MRI and contrast-enhanced MRI using iron oxide nanoparticles at high field (3
T and 7
T), we could precisely locate the subcortical nuclei, in particular the subthalamic nucleus in macaques, and validate this location by intracranial electrophysiological mapping. The present data pave the way to a clinical application.
[Display omitted]
► Identification of the subthalamic nucleus in the non-human primate using MRI at 3T and 7T. ► Contrast enhancement with P904, an ultra-small superparamagnetic iron oxide particle. ► Electrophysiological mapping confirmation of MRI findings. ► Direct visualization of subthalamic nucleus with P904.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21704174</pmid><doi>10.1016/j.neuroimage.2011.06.019</doi><tpages>9</tpages></addata></record> |
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| subjects | Aging - physiology Algorithms Animals Basal Ganglia - anatomy & histology Basal Ganglia - physiology Brain Mapping Brain research Brain Stem - anatomy & histology Brain Stem - physiology Contrast agents Electrophysiological Phenomena Electrophysiology Female High field Image Processing, Computer-Assisted Individuality Iron oxide Laboratory animals Macaca Macaca mulatta Magnetic Resonance Imaging - methods Male Microelectrodes MRI Neurosciences NMR Non human primate Nuclear magnetic resonance Parkinson's disease Patients Primates Probability Quality of life Scanners Signal-To-Noise Ratio Studies Subthalamic nucleus Subthalamic Nucleus - physiology |
| title | Direct visualization of non-human primate subcortical nuclei with contrast-enhanced high field MRI |
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