Effects of C7 substitutions in a high affinity microtubule-binding taxane on antitumor activity and drug transport

Some C-7 modified analogs of 3, a taxane with high affinity for binding to microtubules were prepared. Most of the analogs, bearing less lipophilic C-7 substituents than propionyl in 3, exhibited comparable binding affinities to microtubules but less cytotoxicity against drug-sensitive and multidrug...

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