Impaired MMN/P3a complex in first-episode psychosis: Cognitive and psychosocial associations
Mismatch negativity (MMN) is a neurophysiological indicator of the brain's ability to extract relevant information from an irrelevant background. The P3a orienting response often accompanies MMN in deviance detection paradigms. Both MMN and P3a have been described as reliable biomarkers of schi...
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| Veröffentlicht in: | Progress in neuro-psychopharmacology & biological psychiatry 2010-08, Vol.34 (6), p.822-829 |
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| creator | Hermens, Daniel F. Ward, Philip B. Hodge, M. Antoinette Redoblado Kaur, Manreena Naismith, Sharon L. Hickie, Ian B. |
| description | Mismatch negativity (MMN) is a neurophysiological indicator of the brain's ability to extract relevant information from an irrelevant background. The P3a orienting response often accompanies MMN in deviance detection paradigms. Both MMN and P3a have been described as reliable biomarkers of schizophrenia. MMN/P3a impairments are associated with deficits in verbal memory and attentional switching, reflecting dysfunctions in the temporal and frontal systems, respectively. It remains unresolved whether MMN/P3a are robust biomarkers of psychosis in first-episode patients. Thirty-four young people (18 to 30
years) were assessed in this study; 17 first-episode psychosis (FEP) patients were compared to 17 healthy controls. To elicit MMN/P3a, a two-tone passive auditory oddball paradigm with 8% duration deviants was used; event-related potentials were recorded at frontal, central and temporal (mastoid) sites. Neuropsychological assessments included processing speed, attentional switching, simple attention, and verbal learning and memory. Social functioning and quality of life measures were also obtained. The FEP group showed significantly reduced MMN amplitudes compared to controls. The FEP group also showed significantly reduced P3a amplitudes at frontal and central sites compared with controls. As expected, the FEP group also showed significant deficits in attention and verbal learning/memory. Correlational analyses found strong associations between fronto-central MMN/P3a peak amplitude and cognitive/psychosocial functioning. This study provides evidence of early neurobiological markers in young people with FEP. These findings suggest that MMN/P3a impairments are present at early stages of psychosis and that fundamental pre-attentive/deviance detection deficits may mark the beginning of progressive underlying changes with illness onset. Such deficits in FEP appear to have important links with higher-order cognitive and psychosocial functioning. |
| doi_str_mv | 10.1016/j.pnpbp.2010.03.019 |
| format | Article |
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years) were assessed in this study; 17 first-episode psychosis (FEP) patients were compared to 17 healthy controls. To elicit MMN/P3a, a two-tone passive auditory oddball paradigm with 8% duration deviants was used; event-related potentials were recorded at frontal, central and temporal (mastoid) sites. Neuropsychological assessments included processing speed, attentional switching, simple attention, and verbal learning and memory. Social functioning and quality of life measures were also obtained. The FEP group showed significantly reduced MMN amplitudes compared to controls. The FEP group also showed significantly reduced P3a amplitudes at frontal and central sites compared with controls. As expected, the FEP group also showed significant deficits in attention and verbal learning/memory. Correlational analyses found strong associations between fronto-central MMN/P3a peak amplitude and cognitive/psychosocial functioning. This study provides evidence of early neurobiological markers in young people with FEP. These findings suggest that MMN/P3a impairments are present at early stages of psychosis and that fundamental pre-attentive/deviance detection deficits may mark the beginning of progressive underlying changes with illness onset. Such deficits in FEP appear to have important links with higher-order cognitive and psychosocial functioning.</description><identifier>ISSN: 0278-5846</identifier><identifier>EISSN: 1878-4216</identifier><identifier>DOI: 10.1016/j.pnpbp.2010.03.019</identifier><identifier>PMID: 20302901</identifier><identifier>CODEN: PNPPD7</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Attention - physiology ; Biological and medical sciences ; Brain Mapping ; Cerebral Cortex - physiopathology ; Electroencephalography ; Evoked Potentials - physiology ; Female ; First episode ; Humans ; Male ; Medical sciences ; Memory - physiology ; Mismatch negativity ; Neuropharmacology ; Neuropsychological Tests ; Neuropsychology ; P3a ; Pharmacology. Drug treatments ; Psychosis ; Psychosocial ; Psychotic Disorders - physiopathology ; Psychotic Disorders - psychology ; Quality of Life - psychology ; Reaction Time - physiology ; Signal Processing, Computer-Assisted</subject><ispartof>Progress in neuro-psychopharmacology & biological psychiatry, 2010-08, Vol.34 (6), p.822-829</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright (c) 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-70a248b5680acd58982b517c076031bdd9aac46fb87629b9792b3d7fe4b7d1953</citedby><cites>FETCH-LOGICAL-c486t-70a248b5680acd58982b517c076031bdd9aac46fb87629b9792b3d7fe4b7d1953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.pnpbp.2010.03.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23116697$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20302901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hermens, Daniel F.</creatorcontrib><creatorcontrib>Ward, Philip B.</creatorcontrib><creatorcontrib>Hodge, M. Antoinette Redoblado</creatorcontrib><creatorcontrib>Kaur, Manreena</creatorcontrib><creatorcontrib>Naismith, Sharon L.</creatorcontrib><creatorcontrib>Hickie, Ian B.</creatorcontrib><title>Impaired MMN/P3a complex in first-episode psychosis: Cognitive and psychosocial associations</title><title>Progress in neuro-psychopharmacology & biological psychiatry</title><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><description>Mismatch negativity (MMN) is a neurophysiological indicator of the brain's ability to extract relevant information from an irrelevant background. The P3a orienting response often accompanies MMN in deviance detection paradigms. Both MMN and P3a have been described as reliable biomarkers of schizophrenia. MMN/P3a impairments are associated with deficits in verbal memory and attentional switching, reflecting dysfunctions in the temporal and frontal systems, respectively. It remains unresolved whether MMN/P3a are robust biomarkers of psychosis in first-episode patients. Thirty-four young people (18 to 30
years) were assessed in this study; 17 first-episode psychosis (FEP) patients were compared to 17 healthy controls. To elicit MMN/P3a, a two-tone passive auditory oddball paradigm with 8% duration deviants was used; event-related potentials were recorded at frontal, central and temporal (mastoid) sites. Neuropsychological assessments included processing speed, attentional switching, simple attention, and verbal learning and memory. Social functioning and quality of life measures were also obtained. The FEP group showed significantly reduced MMN amplitudes compared to controls. The FEP group also showed significantly reduced P3a amplitudes at frontal and central sites compared with controls. As expected, the FEP group also showed significant deficits in attention and verbal learning/memory. Correlational analyses found strong associations between fronto-central MMN/P3a peak amplitude and cognitive/psychosocial functioning. This study provides evidence of early neurobiological markers in young people with FEP. These findings suggest that MMN/P3a impairments are present at early stages of psychosis and that fundamental pre-attentive/deviance detection deficits may mark the beginning of progressive underlying changes with illness onset. Such deficits in FEP appear to have important links with higher-order cognitive and psychosocial functioning.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Attention - physiology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Electroencephalography</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>First episode</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory - physiology</subject><subject>Mismatch negativity</subject><subject>Neuropharmacology</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>P3a</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychosis</subject><subject>Psychosocial</subject><subject>Psychotic Disorders - physiopathology</subject><subject>Psychotic Disorders - psychology</subject><subject>Quality of Life - psychology</subject><subject>Reaction Time - physiology</subject><subject>Signal Processing, Computer-Assisted</subject><issn>0278-5846</issn><issn>1878-4216</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUlvFDEQRi1ERIbAL0BCfUGcelK2u70gcYhGLJGycIAbkuWtwaPutrF7IvLvcTITuJFTlcrvK5WeEXqFYY0Bs9PtOs3JpDWBOgG6BiyfoBUWXLQdwewpWgGpfS86doyel7IFAEyBPkPHBCgQCXiFvp9PSYfsXXN5eXX6herGximN_ncT5mYIuSytT6FE55tUbu3PWEJ512zijzks4cY3enYPD9EGPTa63DdLiHN5gY4GPRb_8lBP0LePH75uPrcX15_ON2cXre0EW1oOmnTC9EyAtq4XUhDTY26BM6DYOCe1th0bjOCMSCO5JIY6PvjOcIdlT0_Q2_3elOOvnS-LmkKxfhz17OOuKCF66Amw7lGSd9WKxFRWku5Jm2Mp2Q8q5TDpfKswqDv_aqvu_as7_wqoqsGaen3YvzOTd38zD8Ir8OYA6GL1OGQ921D-cRRjxiSv3Ps956u3m-CzKjb42XpXP8suysXw30P-AHNzpDE</recordid><startdate>20100816</startdate><enddate>20100816</enddate><creator>Hermens, Daniel F.</creator><creator>Ward, Philip B.</creator><creator>Hodge, M. Antoinette Redoblado</creator><creator>Kaur, Manreena</creator><creator>Naismith, Sharon L.</creator><creator>Hickie, Ian B.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>20100816</creationdate><title>Impaired MMN/P3a complex in first-episode psychosis: Cognitive and psychosocial associations</title><author>Hermens, Daniel F. ; Ward, Philip B. ; Hodge, M. Antoinette Redoblado ; Kaur, Manreena ; Naismith, Sharon L. ; Hickie, Ian B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-70a248b5680acd58982b517c076031bdd9aac46fb87629b9792b3d7fe4b7d1953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Attention - physiology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Electroencephalography</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>First episode</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory - physiology</topic><topic>Mismatch negativity</topic><topic>Neuropharmacology</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>P3a</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychosis</topic><topic>Psychosocial</topic><topic>Psychotic Disorders - physiopathology</topic><topic>Psychotic Disorders - psychology</topic><topic>Quality of Life - psychology</topic><topic>Reaction Time - physiology</topic><topic>Signal Processing, Computer-Assisted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hermens, Daniel F.</creatorcontrib><creatorcontrib>Ward, Philip B.</creatorcontrib><creatorcontrib>Hodge, M. Antoinette Redoblado</creatorcontrib><creatorcontrib>Kaur, Manreena</creatorcontrib><creatorcontrib>Naismith, Sharon L.</creatorcontrib><creatorcontrib>Hickie, Ian B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hermens, Daniel F.</au><au>Ward, Philip B.</au><au>Hodge, M. Antoinette Redoblado</au><au>Kaur, Manreena</au><au>Naismith, Sharon L.</au><au>Hickie, Ian B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired MMN/P3a complex in first-episode psychosis: Cognitive and psychosocial associations</atitle><jtitle>Progress in neuro-psychopharmacology & biological psychiatry</jtitle><addtitle>Prog Neuropsychopharmacol Biol Psychiatry</addtitle><date>2010-08-16</date><risdate>2010</risdate><volume>34</volume><issue>6</issue><spage>822</spage><epage>829</epage><pages>822-829</pages><issn>0278-5846</issn><eissn>1878-4216</eissn><coden>PNPPD7</coden><abstract>Mismatch negativity (MMN) is a neurophysiological indicator of the brain's ability to extract relevant information from an irrelevant background. The P3a orienting response often accompanies MMN in deviance detection paradigms. Both MMN and P3a have been described as reliable biomarkers of schizophrenia. MMN/P3a impairments are associated with deficits in verbal memory and attentional switching, reflecting dysfunctions in the temporal and frontal systems, respectively. It remains unresolved whether MMN/P3a are robust biomarkers of psychosis in first-episode patients. Thirty-four young people (18 to 30
years) were assessed in this study; 17 first-episode psychosis (FEP) patients were compared to 17 healthy controls. To elicit MMN/P3a, a two-tone passive auditory oddball paradigm with 8% duration deviants was used; event-related potentials were recorded at frontal, central and temporal (mastoid) sites. Neuropsychological assessments included processing speed, attentional switching, simple attention, and verbal learning and memory. Social functioning and quality of life measures were also obtained. The FEP group showed significantly reduced MMN amplitudes compared to controls. The FEP group also showed significantly reduced P3a amplitudes at frontal and central sites compared with controls. As expected, the FEP group also showed significant deficits in attention and verbal learning/memory. Correlational analyses found strong associations between fronto-central MMN/P3a peak amplitude and cognitive/psychosocial functioning. This study provides evidence of early neurobiological markers in young people with FEP. These findings suggest that MMN/P3a impairments are present at early stages of psychosis and that fundamental pre-attentive/deviance detection deficits may mark the beginning of progressive underlying changes with illness onset. Such deficits in FEP appear to have important links with higher-order cognitive and psychosocial functioning.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20302901</pmid><doi>10.1016/j.pnpbp.2010.03.019</doi><tpages>8</tpages></addata></record> |
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| ispartof | Progress in neuro-psychopharmacology & biological psychiatry, 2010-08, Vol.34 (6), p.822-829 |
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| subjects | Adolescent Adult Attention - physiology Biological and medical sciences Brain Mapping Cerebral Cortex - physiopathology Electroencephalography Evoked Potentials - physiology Female First episode Humans Male Medical sciences Memory - physiology Mismatch negativity Neuropharmacology Neuropsychological Tests Neuropsychology P3a Pharmacology. Drug treatments Psychosis Psychosocial Psychotic Disorders - physiopathology Psychotic Disorders - psychology Quality of Life - psychology Reaction Time - physiology Signal Processing, Computer-Assisted |
| title | Impaired MMN/P3a complex in first-episode psychosis: Cognitive and psychosocial associations |
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