Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time

Jasmonic acid (JA) activates the transcriptional regulator ORCA3, which has a role in regulating the terpenoid indole alkaloid (TIA) pathway within Catharanthus roseus. The TIA pathway leads to the production of the anticancer drugs vinblastine and vincristine. This work explores the transient effec...

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Veröffentlicht in:	Metabolic engineering 2009-03, Vol.11 (2), p.76-86
Hauptverfasser:	Peebles, Christie A.M., Hughes, Erik H., Shanks, Jacqueline V., San, Ka-Yiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitumor agents Catharanthus - physiology Catharanthus roseus Cyclopentanes - administration & dosage Oxylipins - administration & dosage Plant metabolic engineering Plant Proteins - metabolism Plant Roots - metabolism Plants, Genetically Modified - genetics Plants, Genetically Modified - metabolism Q RT PCR Secologanin Tryptamine Alkaloids - metabolism Signal Transduction - drug effects Signal Transduction - physiology Transcript profiling Transcription Factors - metabolism Transcriptional Activation - drug effects Transcriptional Activation - physiology Transcriptional regulation Up-Regulation - drug effects Zinc finger-binding proteins
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