Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad
Highlights ► we assessed the potency of mOPV3 kept at ambient temperatures during a polio vaccination campaign in Chad ► 20 vials were exposed to temperatures of up to 47.1 ∘C, and kept outside 2–8 ∘C range for up to 86.9 hours ► laboratory tests confirmed that all vials still met the potency releas...
Gespeichert in:
| Veröffentlicht in: | Vaccine 2011-08, Vol.29 (34), p.5652-5656 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 5656 |
|---|---|
| container_issue | 34 |
| container_start_page | 5652 |
| container_title | Vaccine |
| container_volume | 29 |
| creator | Zipursky, Simona Boualam, Liliane Cheikh, Dah Ould Fournier-Caruana, Jacqueline Hamid, Djabar Janssen, Mathias Kartoglu, Umit Waeterloos, Genevieve Ronveaux, Olivier |
| description | Highlights ► we assessed the potency of mOPV3 kept at ambient temperatures during a polio vaccination campaign in Chad ► 20 vials were exposed to temperatures of up to 47.1 ∘C, and kept outside 2–8 ∘C range for up to 86.9 hours ► laboratory tests confirmed that all vials still met the potency release specifications - VVMs performed as expected, giving an early warning when cumulative levels of heat could have affected potency ► certain types of OPV can be kept at ambient temperature for limited periods of time, provided a VVM is used. |
| doi_str_mv | 10.1016/j.vaccine.2011.06.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_885051166</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0264410X11008759</els_id><sourcerecordid>879105263</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-6e1f537ec2f787a016891be21aac6ac2b8e3fe73d09720fbc8bab87f069afa803</originalsourceid><addsrcrecordid>eNqFkk1r3DAQhk1padK0P6GtoJSedquxbFm-tISlXxDoIQ30JsbyeFcbW9pKdmDz6ytntw3kktMw8LzvfGbZa-BL4CA_bpc3aIx1tMw5wJLLZQpPslNQlVjkJain2SnPZbEogP8-yV7EuOWclwLq59lJDrKu60KeZrfnMVKM1q3ZuCG28yM5s2e-Yz5gn_LeenasxK5pNzI_jdG2NCOzwvi-ZWaD1rF2CrMPMoej9S7J7TBMzt7epczgsEO7diyhqw22L7NnHfaRXh3jWXb19cuv1ffFxc9vP1bnFwtTCjEuJEFXiopM3lWqwjS7qqGhHBCNRJM3ikRHlWh5XeW8a4xqsFFVx2WNHSouzrIPB99d8H8miqMebDTU9-jIT1ErVfISQMrHyaoGXuZSJPLdA3Lrp5BGjhqKWgFwCXmiygNlgo8xUKd3wQ4Y9hq4nq-ot_q4Wz1fUXOpU0i6N0f3qRmo_a_6d7YEvD8CGA32XUBnbLznigJqUajEvT1wHXqN65CYq8tUqeQcEnK3nM8HgtIFbiwFHY1NL0CtDWRG3Xr7aLOfHjiY3jqb2rqmPcX7veiYa64v56ecfzLtiKuqrMVfSXHcAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1498110612</pqid></control><display><type>article</type><title>Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>ProQuest Central UK/Ireland</source><creator>Zipursky, Simona ; Boualam, Liliane ; Cheikh, Dah Ould ; Fournier-Caruana, Jacqueline ; Hamid, Djabar ; Janssen, Mathias ; Kartoglu, Umit ; Waeterloos, Genevieve ; Ronveaux, Olivier</creator><creatorcontrib>Zipursky, Simona ; Boualam, Liliane ; Cheikh, Dah Ould ; Fournier-Caruana, Jacqueline ; Hamid, Djabar ; Janssen, Mathias ; Kartoglu, Umit ; Waeterloos, Genevieve ; Ronveaux, Olivier</creatorcontrib><description>Highlights ► we assessed the potency of mOPV3 kept at ambient temperatures during a polio vaccination campaign in Chad ► 20 vials were exposed to temperatures of up to 47.1 ∘C, and kept outside 2–8 ∘C range for up to 86.9 hours ► laboratory tests confirmed that all vials still met the potency release specifications - VVMs performed as expected, giving an early warning when cumulative levels of heat could have affected potency ► certain types of OPV can be kept at ambient temperature for limited periods of time, provided a VVM is used.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2011.06.011</identifier><identifier>PMID: 21699946</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Africa ; Allergy and Immunology ; Ambient temperature ; Applied microbiology ; Biological and medical sciences ; Campaign ; Chad ; Clinical Laboratory Techniques ; Cold ; Cold chain ; Controlled temperature chain (CTC) ; cumulative exposure ; Drug Storage ; Fundamental and applied biological sciences. Psychology ; Hot Temperature ; Human viral diseases ; Humans ; Immunization ; Immunization logistics ; Infectious diseases ; Laboratory tests ; Mass Vaccination ; Medical sciences ; Microbiology ; Oral polio vaccine (OPV) ; Polio ; Poliomyelitis ; Poliomyelitis - prevention & control ; Poliovirus Vaccine, Oral - immunology ; Refrigeration ; Vaccine ; Vaccine vial monitor (VVM) ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral diseases ; Viral diseases of the nervous system</subject><ispartof>Vaccine, 2011-08, Vol.29 (34), p.5652-5656</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Aug 5, 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c533t-6e1f537ec2f787a016891be21aac6ac2b8e3fe73d09720fbc8bab87f069afa803</citedby><cites>FETCH-LOGICAL-c533t-6e1f537ec2f787a016891be21aac6ac2b8e3fe73d09720fbc8bab87f069afa803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1498110612?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24419348$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21699946$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zipursky, Simona</creatorcontrib><creatorcontrib>Boualam, Liliane</creatorcontrib><creatorcontrib>Cheikh, Dah Ould</creatorcontrib><creatorcontrib>Fournier-Caruana, Jacqueline</creatorcontrib><creatorcontrib>Hamid, Djabar</creatorcontrib><creatorcontrib>Janssen, Mathias</creatorcontrib><creatorcontrib>Kartoglu, Umit</creatorcontrib><creatorcontrib>Waeterloos, Genevieve</creatorcontrib><creatorcontrib>Ronveaux, Olivier</creatorcontrib><title>Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights ► we assessed the potency of mOPV3 kept at ambient temperatures during a polio vaccination campaign in Chad ► 20 vials were exposed to temperatures of up to 47.1 ∘C, and kept outside 2–8 ∘C range for up to 86.9 hours ► laboratory tests confirmed that all vials still met the potency release specifications - VVMs performed as expected, giving an early warning when cumulative levels of heat could have affected potency ► certain types of OPV can be kept at ambient temperature for limited periods of time, provided a VVM is used.</description><subject>Africa</subject><subject>Allergy and Immunology</subject><subject>Ambient temperature</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Campaign</subject><subject>Chad</subject><subject>Clinical Laboratory Techniques</subject><subject>Cold</subject><subject>Cold chain</subject><subject>Controlled temperature chain (CTC)</subject><subject>cumulative exposure</subject><subject>Drug Storage</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hot Temperature</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunization logistics</subject><subject>Infectious diseases</subject><subject>Laboratory tests</subject><subject>Mass Vaccination</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Oral polio vaccine (OPV)</subject><subject>Polio</subject><subject>Poliomyelitis</subject><subject>Poliomyelitis - prevention & control</subject><subject>Poliovirus Vaccine, Oral - immunology</subject><subject>Refrigeration</subject><subject>Vaccine</subject><subject>Vaccine vial monitor (VVM)</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><subject>Viral diseases</subject><subject>Viral diseases of the nervous system</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk1r3DAQhk1padK0P6GtoJSedquxbFm-tISlXxDoIQ30JsbyeFcbW9pKdmDz6ytntw3kktMw8LzvfGbZa-BL4CA_bpc3aIx1tMw5wJLLZQpPslNQlVjkJain2SnPZbEogP8-yV7EuOWclwLq59lJDrKu60KeZrfnMVKM1q3ZuCG28yM5s2e-Yz5gn_LeenasxK5pNzI_jdG2NCOzwvi-ZWaD1rF2CrMPMoej9S7J7TBMzt7epczgsEO7diyhqw22L7NnHfaRXh3jWXb19cuv1ffFxc9vP1bnFwtTCjEuJEFXiopM3lWqwjS7qqGhHBCNRJM3ikRHlWh5XeW8a4xqsFFVx2WNHSouzrIPB99d8H8miqMebDTU9-jIT1ErVfISQMrHyaoGXuZSJPLdA3Lrp5BGjhqKWgFwCXmiygNlgo8xUKd3wQ4Y9hq4nq-ot_q4Wz1fUXOpU0i6N0f3qRmo_a_6d7YEvD8CGA32XUBnbLznigJqUajEvT1wHXqN65CYq8tUqeQcEnK3nM8HgtIFbiwFHY1NL0CtDWRG3Xr7aLOfHjiY3jqb2rqmPcX7veiYa64v56ecfzLtiKuqrMVfSXHcAg</recordid><startdate>20110805</startdate><enddate>20110805</enddate><creator>Zipursky, Simona</creator><creator>Boualam, Liliane</creator><creator>Cheikh, Dah Ould</creator><creator>Fournier-Caruana, Jacqueline</creator><creator>Hamid, Djabar</creator><creator>Janssen, Mathias</creator><creator>Kartoglu, Umit</creator><creator>Waeterloos, Genevieve</creator><creator>Ronveaux, Olivier</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7T5</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110805</creationdate><title>Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad</title><author>Zipursky, Simona ; Boualam, Liliane ; Cheikh, Dah Ould ; Fournier-Caruana, Jacqueline ; Hamid, Djabar ; Janssen, Mathias ; Kartoglu, Umit ; Waeterloos, Genevieve ; Ronveaux, Olivier</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-6e1f537ec2f787a016891be21aac6ac2b8e3fe73d09720fbc8bab87f069afa803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Africa</topic><topic>Allergy and Immunology</topic><topic>Ambient temperature</topic><topic>Applied microbiology</topic><topic>Biological and medical sciences</topic><topic>Campaign</topic><topic>Chad</topic><topic>Clinical Laboratory Techniques</topic><topic>Cold</topic><topic>Cold chain</topic><topic>Controlled temperature chain (CTC)</topic><topic>cumulative exposure</topic><topic>Drug Storage</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hot Temperature</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunization</topic><topic>Immunization logistics</topic><topic>Infectious diseases</topic><topic>Laboratory tests</topic><topic>Mass Vaccination</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Oral polio vaccine (OPV)</topic><topic>Polio</topic><topic>Poliomyelitis</topic><topic>Poliomyelitis - prevention & control</topic><topic>Poliovirus Vaccine, Oral - immunology</topic><topic>Refrigeration</topic><topic>Vaccine</topic><topic>Vaccine vial monitor (VVM)</topic><topic>Vaccines</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</topic><topic>Viral diseases</topic><topic>Viral diseases of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zipursky, Simona</creatorcontrib><creatorcontrib>Boualam, Liliane</creatorcontrib><creatorcontrib>Cheikh, Dah Ould</creatorcontrib><creatorcontrib>Fournier-Caruana, Jacqueline</creatorcontrib><creatorcontrib>Hamid, Djabar</creatorcontrib><creatorcontrib>Janssen, Mathias</creatorcontrib><creatorcontrib>Kartoglu, Umit</creatorcontrib><creatorcontrib>Waeterloos, Genevieve</creatorcontrib><creatorcontrib>Ronveaux, Olivier</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zipursky, Simona</au><au>Boualam, Liliane</au><au>Cheikh, Dah Ould</au><au>Fournier-Caruana, Jacqueline</au><au>Hamid, Djabar</au><au>Janssen, Mathias</au><au>Kartoglu, Umit</au><au>Waeterloos, Genevieve</au><au>Ronveaux, Olivier</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2011-08-05</date><risdate>2011</risdate><volume>29</volume><issue>34</issue><spage>5652</spage><epage>5656</epage><pages>5652-5656</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Highlights ► we assessed the potency of mOPV3 kept at ambient temperatures during a polio vaccination campaign in Chad ► 20 vials were exposed to temperatures of up to 47.1 ∘C, and kept outside 2–8 ∘C range for up to 86.9 hours ► laboratory tests confirmed that all vials still met the potency release specifications - VVMs performed as expected, giving an early warning when cumulative levels of heat could have affected potency ► certain types of OPV can be kept at ambient temperature for limited periods of time, provided a VVM is used.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21699946</pmid><doi>10.1016/j.vaccine.2011.06.011</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0264-410X |
| ispartof | Vaccine, 2011-08, Vol.29 (34), p.5652-5656 |
| issn | 0264-410X 1873-2518 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_885051166 |
| source | MEDLINE; Elsevier ScienceDirect Journals; ProQuest Central UK/Ireland |
| subjects | Africa Allergy and Immunology Ambient temperature Applied microbiology Biological and medical sciences Campaign Chad Clinical Laboratory Techniques Cold Cold chain Controlled temperature chain (CTC) cumulative exposure Drug Storage Fundamental and applied biological sciences. Psychology Hot Temperature Human viral diseases Humans Immunization Immunization logistics Infectious diseases Laboratory tests Mass Vaccination Medical sciences Microbiology Oral polio vaccine (OPV) Polio Poliomyelitis Poliomyelitis - prevention & control Poliovirus Vaccine, Oral - immunology Refrigeration Vaccine Vaccine vial monitor (VVM) Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral diseases Viral diseases of the nervous system |
| title | Assessing the potency of oral polio vaccine kept outside of the cold chain during a national immunization campaign in Chad |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T02%3A13%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Assessing%20the%20potency%20of%20oral%20polio%20vaccine%20kept%20outside%20of%20the%20cold%20chain%20during%20a%20national%20immunization%20campaign%20in%20Chad&rft.jtitle=Vaccine&rft.au=Zipursky,%20Simona&rft.date=2011-08-05&rft.volume=29&rft.issue=34&rft.spage=5652&rft.epage=5656&rft.pages=5652-5656&rft.issn=0264-410X&rft.eissn=1873-2518&rft.coden=VACCDE&rft_id=info:doi/10.1016/j.vaccine.2011.06.011&rft_dat=%3Cproquest_cross%3E879105263%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1498110612&rft_id=info:pmid/21699946&rft_els_id=S0264410X11008759&rfr_iscdi=true |