A new oral vaccine candidate based on the microencapsulation by spray-drying of inactivated Vibrio cholerae

Abstract The aim of this work was to evaluate the microencapsulation by spray-drying of inactivated Vibrio cholerae , using methacrylic copolymers Eudragit® L30D-55 and FS30D. The microparticles obtained presented a particle size around 3.0 μm. The preparation temperature affected the morphology and...

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Veröffentlicht in:	Vaccine 2011-08, Vol.29 (34), p.5758-5764
Hauptverfasser:	Año, Gemma, Esquisabel, Amaia, Pastor, Marta, Talavera, Arturo, Cedré, Bárbara, Fernández, Sonsire, Sifontes, Sergio, Aranguren, Yisabel, Falero, Gustavo, García, Luis, Solís, Rosa Lydia, Pedraz, José Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Allergy and Immunology Animals Applied microbiology bacteria Bacteriology Biological and medical sciences Candidates Cholera Cholera - immunology Cholera - prevention & control Cholera vaccine Cholera Vaccines - administration & dosage Cholera Vaccines - immunology composite polymers Desiccation Drug Compounding Drug dosages Drying Enteric microparticles Eudragit Fundamental and applied biological sciences. Psychology Microbial Viability - immunology Microbiology microencapsulation Microspheres Miscellaneous particle size Polymers Polymethacrylic Acids Rats Solvents Spray drying temperature Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Inactivated - immunology Vibrio cholerae Vibrio cholerae - immunology
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