1-Aminobenzotriazole, a Known Cytochrome P450 Inhibitor, Is a Substrate and Inhibitor of N-Acetyltransferase

1-Aminobenzotriazole (ABT) has been used widely as a nonselective in vitro and in vivo inhibitor of cytochrome P450 enzymes. To date, however, it has not been evaluated as an inhibitor of UDP-glucuronosyltransferase (UGT), sulfotransferase (SULT), and N-acetyltransferase (NAT). In the present study,...

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Veröffentlicht in:	Drug metabolism and disposition 2011-09, Vol.39 (9), p.1674-1679
Hauptverfasser:	SUN, Q, HARPER, T. W, DIERKS, E. A, ZHANG, L, CHANG, S, RODRIGUES, A. D, MARATHE, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - metabolism Acetylation - drug effects Animals Arylamine N-Acetyltransferase - antagonists & inhibitors Arylamine N-Acetyltransferase - metabolism Biological and medical sciences Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Glucuronosyltransferase - metabolism Humans Isoenzymes - antagonists & inhibitors Isoenzymes - metabolism Male Medical sciences Microsomes, Liver - enzymology Microsomes, Liver - metabolism Pharmacology. Drug treatments Procainamide - metabolism Rats Rats, Sprague-Dawley Sulfotransferases - metabolism Triazoles - metabolism Triazoles - pharmacology Umbelliferones - metabolism
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