Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation
Abstract Profilin-1, a regulator of actin polymerization, has recently been linked to vascular hypertrophy and remodeling. Whether profilin-1 is involved in angiotensin (Ang) II-induced proliferation of vascular smooth muscle cells leading to vascular remodeling in hypertension remains unclear. The...
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| Veröffentlicht in: | Vascular pharmacology 2011-07, Vol.55 (1), p.34-41 |
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| creator | Cheng, Jin-Fang Ni, Guo-Hua Chen, Mei-Fang Li, Yuan-Jian Wang, Yong-Jin Wang, Chang-Lu Yuan, Qiong Shi, Rui-Zheng Hu, Chang-Ping Yang, Tian-Lun |
| description | Abstract Profilin-1, a regulator of actin polymerization, has recently been linked to vascular hypertrophy and remodeling. Whether profilin-1 is involved in angiotensin (Ang) II-induced proliferation of vascular smooth muscle cells leading to vascular remodeling in hypertension remains unclear. The present study was designed to analyze the correlation of profilin-1 and vascular remodeling during hypertension and to evaluate the role of profilin-1 in proliferation of vascular smooth muscle cells and the underlying mechanisms. The vascular morphology and the expression of profilin-1 in arterial tissues of spontaneously hypertensive rats and Wistar–Kyoto rats were assessed. The profilin-1 expression was significantly increased concomitantly with definite vascular remodeling by evaluating the media thickness, lumen diameter, media thickness-to-lumen diameter ratio and mean nuclear area in artery media in spontaneously hypertensive rats, which was inhibited by treatment with losartan. In cultured rat aortic smooth muscle cells (RASMCs), Ang II induced profilin-1 expression in a dose- and time-dependent manner. Knockdown of profilin-1 using small hairpin RNA inhibited Ang II-induced proliferation of RASMCs. Moreover, blockade of JAK2/STAT3 signaling pathway also inhibited Ang II-induced proliferation of RASMCs and profilin-1 expression. These results suggest that profilin-1 mediates the proliferation of RASMCs induced by Ang II via activation of Ang II type 1 receptor/JAK2/STAT3 signaling pathway, which may contribute to vascular remodeling in hypertension. |
| doi_str_mv | 10.1016/j.vph.2011.04.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_884848389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1537189111000358</els_id><sourcerecordid>884848389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c407t-fb1f1c868e1752c89792e5a61626adcfa4c90ce22d086e436568bcf43a4eda313</originalsourceid><addsrcrecordid>eNp9kUFv1DAQhS0EoqXwA7ig3DgleGLHsYWEhKoCK1XqgfaILK8zpl4Se7GTSP33ONrCgUPlg-fw3vP4e4S8BdoABfHh0KzH-6alAA3lDaXsGTkH2auaCa6el7ljfQ1SwRl5lfOBUpBSqJfkrIVOCsbUOfmxC2scV5wwzFV01TFF50cfaqh8qEz46eOMIZd5t6t9GBaLQ7WabJfRpCpPMc731bRkO2JlcRy3gNE7TGb2MbwmL5wZM755vC_I3Zer28tv9fXN193l5-vactrPtduDAyuFROi71krVqxY7I0C0wgzWGW4Vtdi2A5UCOROdkHvrODMcB8OAXZD3p9zy-u8F86wnn7d1TMC4ZC0lL4dJVZRwUtoUc07o9DH5yaQHDVRvUPVBF6h6g6op1wVq8bx7TF_2Ew7_HH8pFsHHkwDLH1ePSWfrMRRUPqGd9RD9k_Gf_nPbUoC3ZvyFD5gPcUmhwNOgc6up_r61upUKQIu9k-wPruOdlA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>884848389</pqid></control><display><type>article</type><title>Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Cheng, Jin-Fang ; Ni, Guo-Hua ; Chen, Mei-Fang ; Li, Yuan-Jian ; Wang, Yong-Jin ; Wang, Chang-Lu ; Yuan, Qiong ; Shi, Rui-Zheng ; Hu, Chang-Ping ; Yang, Tian-Lun</creator><creatorcontrib>Cheng, Jin-Fang ; Ni, Guo-Hua ; Chen, Mei-Fang ; Li, Yuan-Jian ; Wang, Yong-Jin ; Wang, Chang-Lu ; Yuan, Qiong ; Shi, Rui-Zheng ; Hu, Chang-Ping ; Yang, Tian-Lun</creatorcontrib><description>Abstract Profilin-1, a regulator of actin polymerization, has recently been linked to vascular hypertrophy and remodeling. Whether profilin-1 is involved in angiotensin (Ang) II-induced proliferation of vascular smooth muscle cells leading to vascular remodeling in hypertension remains unclear. The present study was designed to analyze the correlation of profilin-1 and vascular remodeling during hypertension and to evaluate the role of profilin-1 in proliferation of vascular smooth muscle cells and the underlying mechanisms. The vascular morphology and the expression of profilin-1 in arterial tissues of spontaneously hypertensive rats and Wistar–Kyoto rats were assessed. The profilin-1 expression was significantly increased concomitantly with definite vascular remodeling by evaluating the media thickness, lumen diameter, media thickness-to-lumen diameter ratio and mean nuclear area in artery media in spontaneously hypertensive rats, which was inhibited by treatment with losartan. In cultured rat aortic smooth muscle cells (RASMCs), Ang II induced profilin-1 expression in a dose- and time-dependent manner. Knockdown of profilin-1 using small hairpin RNA inhibited Ang II-induced proliferation of RASMCs. Moreover, blockade of JAK2/STAT3 signaling pathway also inhibited Ang II-induced proliferation of RASMCs and profilin-1 expression. These results suggest that profilin-1 mediates the proliferation of RASMCs induced by Ang II via activation of Ang II type 1 receptor/JAK2/STAT3 signaling pathway, which may contribute to vascular remodeling in hypertension.</description><identifier>ISSN: 1537-1891</identifier><identifier>EISSN: 1879-3649</identifier><identifier>DOI: 10.1016/j.vph.2011.04.003</identifier><identifier>PMID: 21586339</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Angiotensin II ; Angiotensin II - metabolism ; Angiotensin II - pharmacology ; Animals ; Aorta, Thoracic - drug effects ; Aorta, Thoracic - metabolism ; Blood Pressure - drug effects ; Cardiovascular ; Cell Growth Processes - drug effects ; Cell Growth Processes - physiology ; Cells, Cultured ; Gene Knockdown Techniques - methods ; Hypertension ; Hypertension - metabolism ; Janus Kinase 2 - antagonists & inhibitors ; Janus Kinase 2 - metabolism ; Losartan - pharmacology ; Male ; Mesenteric Arteries - cytology ; Mesenteric Arteries - drug effects ; Mesenteric Arteries - metabolism ; Muscle, Smooth, Vascular - cytology ; Muscle, Smooth, Vascular - drug effects ; Muscle, Smooth, Vascular - metabolism ; Myocytes, Smooth Muscle - cytology ; Myocytes, Smooth Muscle - drug effects ; Myocytes, Smooth Muscle - metabolism ; Profilin-1 ; Profilins - antagonists & inhibitors ; Profilins - genetics ; Profilins - metabolism ; Proliferation ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Receptor, Angiotensin, Type 1 - metabolism ; Signal Transduction - drug effects ; STAT3 Transcription Factor - antagonists & inhibitors ; STAT3 Transcription Factor - metabolism ; Vascular smooth muscle cells</subject><ispartof>Vascular pharmacology, 2011-07, Vol.55 (1), p.34-41</ispartof><rights>Elsevier Inc.</rights><rights>2011 Elsevier Inc.</rights><rights>Copyright © 2011 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-fb1f1c868e1752c89792e5a61626adcfa4c90ce22d086e436568bcf43a4eda313</citedby><cites>FETCH-LOGICAL-c407t-fb1f1c868e1752c89792e5a61626adcfa4c90ce22d086e436568bcf43a4eda313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1537189111000358$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21586339$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cheng, Jin-Fang</creatorcontrib><creatorcontrib>Ni, Guo-Hua</creatorcontrib><creatorcontrib>Chen, Mei-Fang</creatorcontrib><creatorcontrib>Li, Yuan-Jian</creatorcontrib><creatorcontrib>Wang, Yong-Jin</creatorcontrib><creatorcontrib>Wang, Chang-Lu</creatorcontrib><creatorcontrib>Yuan, Qiong</creatorcontrib><creatorcontrib>Shi, Rui-Zheng</creatorcontrib><creatorcontrib>Hu, Chang-Ping</creatorcontrib><creatorcontrib>Yang, Tian-Lun</creatorcontrib><title>Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation</title><title>Vascular pharmacology</title><addtitle>Vascul Pharmacol</addtitle><description>Abstract Profilin-1, a regulator of actin polymerization, has recently been linked to vascular hypertrophy and remodeling. Whether profilin-1 is involved in angiotensin (Ang) II-induced proliferation of vascular smooth muscle cells leading to vascular remodeling in hypertension remains unclear. The present study was designed to analyze the correlation of profilin-1 and vascular remodeling during hypertension and to evaluate the role of profilin-1 in proliferation of vascular smooth muscle cells and the underlying mechanisms. The vascular morphology and the expression of profilin-1 in arterial tissues of spontaneously hypertensive rats and Wistar–Kyoto rats were assessed. The profilin-1 expression was significantly increased concomitantly with definite vascular remodeling by evaluating the media thickness, lumen diameter, media thickness-to-lumen diameter ratio and mean nuclear area in artery media in spontaneously hypertensive rats, which was inhibited by treatment with losartan. In cultured rat aortic smooth muscle cells (RASMCs), Ang II induced profilin-1 expression in a dose- and time-dependent manner. Knockdown of profilin-1 using small hairpin RNA inhibited Ang II-induced proliferation of RASMCs. Moreover, blockade of JAK2/STAT3 signaling pathway also inhibited Ang II-induced proliferation of RASMCs and profilin-1 expression. These results suggest that profilin-1 mediates the proliferation of RASMCs induced by Ang II via activation of Ang II type 1 receptor/JAK2/STAT3 signaling pathway, which may contribute to vascular remodeling in hypertension.</description><subject>Angiotensin II</subject><subject>Angiotensin II - metabolism</subject><subject>Angiotensin II - pharmacology</subject><subject>Animals</subject><subject>Aorta, Thoracic - drug effects</subject><subject>Aorta, Thoracic - metabolism</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiovascular</subject><subject>Cell Growth Processes - drug effects</subject><subject>Cell Growth Processes - physiology</subject><subject>Cells, Cultured</subject><subject>Gene Knockdown Techniques - methods</subject><subject>Hypertension</subject><subject>Hypertension - metabolism</subject><subject>Janus Kinase 2 - antagonists & inhibitors</subject><subject>Janus Kinase 2 - metabolism</subject><subject>Losartan - pharmacology</subject><subject>Male</subject><subject>Mesenteric Arteries - cytology</subject><subject>Mesenteric Arteries - drug effects</subject><subject>Mesenteric Arteries - metabolism</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Muscle, Smooth, Vascular - drug effects</subject><subject>Muscle, Smooth, Vascular - metabolism</subject><subject>Myocytes, Smooth Muscle - cytology</subject><subject>Myocytes, Smooth Muscle - drug effects</subject><subject>Myocytes, Smooth Muscle - metabolism</subject><subject>Profilin-1</subject><subject>Profilins - antagonists & inhibitors</subject><subject>Profilins - genetics</subject><subject>Profilins - metabolism</subject><subject>Proliferation</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Receptor, Angiotensin, Type 1 - metabolism</subject><subject>Signal Transduction - drug effects</subject><subject>STAT3 Transcription Factor - antagonists & inhibitors</subject><subject>STAT3 Transcription Factor - metabolism</subject><subject>Vascular smooth muscle cells</subject><issn>1537-1891</issn><issn>1879-3649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFv1DAQhS0EoqXwA7ig3DgleGLHsYWEhKoCK1XqgfaILK8zpl4Se7GTSP33ONrCgUPlg-fw3vP4e4S8BdoABfHh0KzH-6alAA3lDaXsGTkH2auaCa6el7ljfQ1SwRl5lfOBUpBSqJfkrIVOCsbUOfmxC2scV5wwzFV01TFF50cfaqh8qEz46eOMIZd5t6t9GBaLQ7WabJfRpCpPMc731bRkO2JlcRy3gNE7TGb2MbwmL5wZM755vC_I3Zer28tv9fXN193l5-vactrPtduDAyuFROi71krVqxY7I0C0wgzWGW4Vtdi2A5UCOROdkHvrODMcB8OAXZD3p9zy-u8F86wnn7d1TMC4ZC0lL4dJVZRwUtoUc07o9DH5yaQHDVRvUPVBF6h6g6op1wVq8bx7TF_2Ew7_HH8pFsHHkwDLH1ePSWfrMRRUPqGd9RD9k_Gf_nPbUoC3ZvyFD5gPcUmhwNOgc6up_r61upUKQIu9k-wPruOdlA</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Cheng, Jin-Fang</creator><creator>Ni, Guo-Hua</creator><creator>Chen, Mei-Fang</creator><creator>Li, Yuan-Jian</creator><creator>Wang, Yong-Jin</creator><creator>Wang, Chang-Lu</creator><creator>Yuan, Qiong</creator><creator>Shi, Rui-Zheng</creator><creator>Hu, Chang-Ping</creator><creator>Yang, Tian-Lun</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110701</creationdate><title>Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation</title><author>Cheng, Jin-Fang ; Ni, Guo-Hua ; Chen, Mei-Fang ; Li, Yuan-Jian ; Wang, Yong-Jin ; Wang, Chang-Lu ; Yuan, Qiong ; Shi, Rui-Zheng ; Hu, Chang-Ping ; Yang, Tian-Lun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-fb1f1c868e1752c89792e5a61626adcfa4c90ce22d086e436568bcf43a4eda313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Angiotensin II</topic><topic>Angiotensin II - metabolism</topic><topic>Angiotensin II - pharmacology</topic><topic>Animals</topic><topic>Aorta, Thoracic - drug effects</topic><topic>Aorta, Thoracic - metabolism</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiovascular</topic><topic>Cell Growth Processes - drug effects</topic><topic>Cell Growth Processes - physiology</topic><topic>Cells, Cultured</topic><topic>Gene Knockdown Techniques - methods</topic><topic>Hypertension</topic><topic>Hypertension - metabolism</topic><topic>Janus Kinase 2 - antagonists & inhibitors</topic><topic>Janus Kinase 2 - metabolism</topic><topic>Losartan - pharmacology</topic><topic>Male</topic><topic>Mesenteric Arteries - cytology</topic><topic>Mesenteric Arteries - drug effects</topic><topic>Mesenteric Arteries - metabolism</topic><topic>Muscle, Smooth, Vascular - cytology</topic><topic>Muscle, Smooth, Vascular - drug effects</topic><topic>Muscle, Smooth, Vascular - metabolism</topic><topic>Myocytes, Smooth Muscle - cytology</topic><topic>Myocytes, Smooth Muscle - drug effects</topic><topic>Myocytes, Smooth Muscle - metabolism</topic><topic>Profilin-1</topic><topic>Profilins - antagonists & inhibitors</topic><topic>Profilins - genetics</topic><topic>Profilins - metabolism</topic><topic>Proliferation</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Receptor, Angiotensin, Type 1 - metabolism</topic><topic>Signal Transduction - drug effects</topic><topic>STAT3 Transcription Factor - antagonists & inhibitors</topic><topic>STAT3 Transcription Factor - metabolism</topic><topic>Vascular smooth muscle cells</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cheng, Jin-Fang</creatorcontrib><creatorcontrib>Ni, Guo-Hua</creatorcontrib><creatorcontrib>Chen, Mei-Fang</creatorcontrib><creatorcontrib>Li, Yuan-Jian</creatorcontrib><creatorcontrib>Wang, Yong-Jin</creatorcontrib><creatorcontrib>Wang, Chang-Lu</creatorcontrib><creatorcontrib>Yuan, Qiong</creatorcontrib><creatorcontrib>Shi, Rui-Zheng</creatorcontrib><creatorcontrib>Hu, Chang-Ping</creatorcontrib><creatorcontrib>Yang, Tian-Lun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cheng, Jin-Fang</au><au>Ni, Guo-Hua</au><au>Chen, Mei-Fang</au><au>Li, Yuan-Jian</au><au>Wang, Yong-Jin</au><au>Wang, Chang-Lu</au><au>Yuan, Qiong</au><au>Shi, Rui-Zheng</au><au>Hu, Chang-Ping</au><au>Yang, Tian-Lun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation</atitle><jtitle>Vascular pharmacology</jtitle><addtitle>Vascul Pharmacol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>55</volume><issue>1</issue><spage>34</spage><epage>41</epage><pages>34-41</pages><issn>1537-1891</issn><eissn>1879-3649</eissn><abstract>Abstract Profilin-1, a regulator of actin polymerization, has recently been linked to vascular hypertrophy and remodeling. Whether profilin-1 is involved in angiotensin (Ang) II-induced proliferation of vascular smooth muscle cells leading to vascular remodeling in hypertension remains unclear. The present study was designed to analyze the correlation of profilin-1 and vascular remodeling during hypertension and to evaluate the role of profilin-1 in proliferation of vascular smooth muscle cells and the underlying mechanisms. The vascular morphology and the expression of profilin-1 in arterial tissues of spontaneously hypertensive rats and Wistar–Kyoto rats were assessed. The profilin-1 expression was significantly increased concomitantly with definite vascular remodeling by evaluating the media thickness, lumen diameter, media thickness-to-lumen diameter ratio and mean nuclear area in artery media in spontaneously hypertensive rats, which was inhibited by treatment with losartan. In cultured rat aortic smooth muscle cells (RASMCs), Ang II induced profilin-1 expression in a dose- and time-dependent manner. Knockdown of profilin-1 using small hairpin RNA inhibited Ang II-induced proliferation of RASMCs. Moreover, blockade of JAK2/STAT3 signaling pathway also inhibited Ang II-induced proliferation of RASMCs and profilin-1 expression. These results suggest that profilin-1 mediates the proliferation of RASMCs induced by Ang II via activation of Ang II type 1 receptor/JAK2/STAT3 signaling pathway, which may contribute to vascular remodeling in hypertension.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21586339</pmid><doi>10.1016/j.vph.2011.04.003</doi><tpages>8</tpages></addata></record> |
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| ispartof | Vascular pharmacology, 2011-07, Vol.55 (1), p.34-41 |
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| subjects | Angiotensin II Angiotensin II - metabolism Angiotensin II - pharmacology Animals Aorta, Thoracic - drug effects Aorta, Thoracic - metabolism Blood Pressure - drug effects Cardiovascular Cell Growth Processes - drug effects Cell Growth Processes - physiology Cells, Cultured Gene Knockdown Techniques - methods Hypertension Hypertension - metabolism Janus Kinase 2 - antagonists & inhibitors Janus Kinase 2 - metabolism Losartan - pharmacology Male Mesenteric Arteries - cytology Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - cytology Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Profilin-1 Profilins - antagonists & inhibitors Profilins - genetics Profilins - metabolism Proliferation Rats Rats, Inbred SHR Rats, Inbred WKY Receptor, Angiotensin, Type 1 - metabolism Signal Transduction - drug effects STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Vascular smooth muscle cells |
| title | Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation |
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