Matrix Metalloproteinase-8 Is Overexpressed in Waldenström's Macroglobulinemia Cells, and Specific Inhibition of this Metalloproteinase Blocks Release of Soluble CD27

Abstract Soluble CD27 (sCD27) is produced by Waldenström's macroglobulinemia (WM) cells, with high levels found in WM patients which may facilitate disease expansion. Matrix metalloproteinases (MMP) may facilitate sCD27 release by cleavage of CD27. By gene expression analysis, we observed signi...

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Veröffentlicht in:	Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2011-02, Vol.11 (1), p.172-175
Hauptverfasser:	Zhou, Yangsheng, Liu, Xia, Xu, Lian, Tseng, Hsiuyi, Cao, Yang, Jiang, Jingrui, Ciccarelli, Bryan T, Yang, Guang, Patterson, Christopher J, Hunter, Zachary R, Treon, Steven P
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD19 - metabolism Bone Marrow Cells - metabolism Cluster Analysis Enzyme Inhibitors - pharmacology Gene Expression Profiling Gene Expression Regulation Hematology, Oncology and Palliative Medicine Humans Matrix Metalloproteinase 8 - genetics Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase Inhibitors Transfection Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics Tumor Necrosis Factor Receptor Superfamily, Member 7 - metabolism Waldenstrom Macroglobulinemia - enzymology Waldenstrom Macroglobulinemia - genetics
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