Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea
The present study evaluates the Philippine medicinal plant Artemisia vulgaris for antagonistic activity at selected biogenic amine receptors on smooth muscle of the airways and gastrointestinal tract in order to explain its traditional use in asthma and hyperactive gut. The antagonistic activity of...
Gespeichert in:
| Veröffentlicht in: | Journal of ethnopharmacology 2011-09, Vol.137 (1), p.808-816 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 816 |
|---|---|
| container_issue | 1 |
| container_start_page | 808 |
| container_title | Journal of ethnopharmacology |
| container_volume | 137 |
| creator | Natividad, Gaudencio M. Broadley, Kenneth J. Kariuki, Benson Kidd, Emma J. Ford, William R. Simons, Claire |
| description | The present study evaluates the Philippine medicinal plant Artemisia vulgaris for antagonistic activity at selected biogenic amine receptors on smooth muscle of the airways and gastrointestinal tract in order to explain its traditional use in asthma and hyperactive gut.
The antagonistic activity of chloroform crude extract (AV-CHCl3) and methanol crude extract (AV-MeOH) of Artemisia vulgaris was studied against concentration–response curves for contractions of the guinea pig ileum and trachea to 5-hydroxytrptamine (5-HT2 receptors), methacholine (M3 muscarinic receptors), histamine (H1 receptors) and β-phenylethylamine (trace amine-associated receptors, TAAR1).
The Artemisia vulgaris chloroform (AV-CHCl3) and methanol (AV-MeOH) extract showed histamine H1 antagonism in the ileum and trachea. Further analysis of AV-CHCl3 isolated two major components, yomogin and 1,2,3,4-diepoxy-11(13)-eudesmen-12,8-olide. Yomogin, a sesquiterpene lactone, exhibited a novel histamine H1 receptor antagonism in the ileum.
The presence of a specific, competitive histamine receptor antagonist and smooth muscle relaxant activity in Artemisia vulgaris extracts on the smooth muscle in ileum and trachea explains its traditional use in the treatment of asthma and hyperactive gut. |
| doi_str_mv | 10.1016/j.jep.2011.06.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_884847532</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378874111004715</els_id><sourcerecordid>884847532</sourcerecordid><originalsourceid>FETCH-LOGICAL-c382t-ac3cb5fff235322b4e363ab76b73de906db593a2ce8fb6da13b9781d9f27c39f3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0EoreFB2CDvEGsEvyT2IlYXVVAkSp1064txxkHX-Xaqe1U8Bo8Mb4_wK6r2Xxzzsw5CL2jpKaEik-7egdLzQilNRE1adgLtKGdZJVsJX-JNoTLrupkQy_QZUo7QoikDXmNLhiVgkkhNuj31mQXfMLB4m3MsHfJafy0zpOOLmH4maM2OWHtR-xSmHWGESdIj6vLEBfwgOcCBA-FmbTzKeMIBpYcYsJ7GJ3Ozk_YBH9UKl4Hq2l1HjRe3ITdDOv-qH8AfoB-g15ZPSd4e55X6OHrl_vrm-r27tv36-1tZXjHcqUNN0NrrWW85YwNDXDB9SDFIPkIPRHj0PZcMwOdHcSoKR962dGxt0wa3lt-hT6edJcYHldIWZXnDcyz9hDWpLqu6RpZtAtJT6SJIaUIVi3R7XX8pShRhybUTpUm1KEJRYQqTZSd92f1dSgx_Nv4G30BPpwBnYyebdTeuPSfa1rSkqP55xMHJYsnB1El48CbEm0JOqsxuGfO-ANnB6qV</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>884847532</pqid></control><display><type>article</type><title>Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Natividad, Gaudencio M. ; Broadley, Kenneth J. ; Kariuki, Benson ; Kidd, Emma J. ; Ford, William R. ; Simons, Claire</creator><creatorcontrib>Natividad, Gaudencio M. ; Broadley, Kenneth J. ; Kariuki, Benson ; Kidd, Emma J. ; Ford, William R. ; Simons, Claire</creatorcontrib><description>The present study evaluates the Philippine medicinal plant Artemisia vulgaris for antagonistic activity at selected biogenic amine receptors on smooth muscle of the airways and gastrointestinal tract in order to explain its traditional use in asthma and hyperactive gut.
The antagonistic activity of chloroform crude extract (AV-CHCl3) and methanol crude extract (AV-MeOH) of Artemisia vulgaris was studied against concentration–response curves for contractions of the guinea pig ileum and trachea to 5-hydroxytrptamine (5-HT2 receptors), methacholine (M3 muscarinic receptors), histamine (H1 receptors) and β-phenylethylamine (trace amine-associated receptors, TAAR1).
The Artemisia vulgaris chloroform (AV-CHCl3) and methanol (AV-MeOH) extract showed histamine H1 antagonism in the ileum and trachea. Further analysis of AV-CHCl3 isolated two major components, yomogin and 1,2,3,4-diepoxy-11(13)-eudesmen-12,8-olide. Yomogin, a sesquiterpene lactone, exhibited a novel histamine H1 receptor antagonism in the ileum.
The presence of a specific, competitive histamine receptor antagonist and smooth muscle relaxant activity in Artemisia vulgaris extracts on the smooth muscle in ileum and trachea explains its traditional use in the treatment of asthma and hyperactive gut.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2011.06.042</identifier><identifier>PMID: 21762766</identifier><identifier>CODEN: JOETD7</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antihistamine ; Artemisia - chemistry ; Artemisia vulgaris ; Asthma ; Biological and medical sciences ; Chloroform - chemistry ; Dose-Response Relationship, Drug ; General pharmacology ; Guinea Pigs ; Histamine H1 Antagonists - pharmacology ; Ileum ; Ileum - drug effects ; Ileum - metabolism ; In Vitro Techniques ; Lactones - pharmacology ; Male ; Medical sciences ; Methanol - chemistry ; Muscle Contraction - drug effects ; Muscle Relaxation - drug effects ; Muscle, Smooth - drug effects ; Muscle, Smooth - metabolism ; Neurotransmitter Agents - chemistry ; Neurotransmitter Agents - isolation & purification ; Neurotransmitter Agents - pharmacology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plants, Medicinal ; Receptor, Muscarinic M3 - drug effects ; Receptor, Muscarinic M3 - metabolism ; Receptors, G-Protein-Coupled - drug effects ; Receptors, G-Protein-Coupled - metabolism ; Receptors, Histamine H1 - drug effects ; Receptors, Histamine H1 - metabolism ; Receptors, Serotonin, 5-HT2 - drug effects ; Receptors, Serotonin, 5-HT2 - metabolism ; Sesquiterpenes, Eudesmane - chemistry ; Sesquiterpenes, Eudesmane - isolation & purification ; Sesquiterpenes, Eudesmane - pharmacology ; Sesquiterpenoids ; Solvents - chemistry ; Trachea - drug effects ; Trachea - metabolism</subject><ispartof>Journal of ethnopharmacology, 2011-09, Vol.137 (1), p.808-816</ispartof><rights>2011 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-ac3cb5fff235322b4e363ab76b73de906db593a2ce8fb6da13b9781d9f27c39f3</citedby><cites>FETCH-LOGICAL-c382t-ac3cb5fff235322b4e363ab76b73de906db593a2ce8fb6da13b9781d9f27c39f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874111004715$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24505032$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21762766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Natividad, Gaudencio M.</creatorcontrib><creatorcontrib>Broadley, Kenneth J.</creatorcontrib><creatorcontrib>Kariuki, Benson</creatorcontrib><creatorcontrib>Kidd, Emma J.</creatorcontrib><creatorcontrib>Ford, William R.</creatorcontrib><creatorcontrib>Simons, Claire</creatorcontrib><title>Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>The present study evaluates the Philippine medicinal plant Artemisia vulgaris for antagonistic activity at selected biogenic amine receptors on smooth muscle of the airways and gastrointestinal tract in order to explain its traditional use in asthma and hyperactive gut.
The antagonistic activity of chloroform crude extract (AV-CHCl3) and methanol crude extract (AV-MeOH) of Artemisia vulgaris was studied against concentration–response curves for contractions of the guinea pig ileum and trachea to 5-hydroxytrptamine (5-HT2 receptors), methacholine (M3 muscarinic receptors), histamine (H1 receptors) and β-phenylethylamine (trace amine-associated receptors, TAAR1).
The Artemisia vulgaris chloroform (AV-CHCl3) and methanol (AV-MeOH) extract showed histamine H1 antagonism in the ileum and trachea. Further analysis of AV-CHCl3 isolated two major components, yomogin and 1,2,3,4-diepoxy-11(13)-eudesmen-12,8-olide. Yomogin, a sesquiterpene lactone, exhibited a novel histamine H1 receptor antagonism in the ileum.
The presence of a specific, competitive histamine receptor antagonist and smooth muscle relaxant activity in Artemisia vulgaris extracts on the smooth muscle in ileum and trachea explains its traditional use in the treatment of asthma and hyperactive gut.</description><subject>Animals</subject><subject>Antihistamine</subject><subject>Artemisia - chemistry</subject><subject>Artemisia vulgaris</subject><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Chloroform - chemistry</subject><subject>Dose-Response Relationship, Drug</subject><subject>General pharmacology</subject><subject>Guinea Pigs</subject><subject>Histamine H1 Antagonists - pharmacology</subject><subject>Ileum</subject><subject>Ileum - drug effects</subject><subject>Ileum - metabolism</subject><subject>In Vitro Techniques</subject><subject>Lactones - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Methanol - chemistry</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Relaxation - drug effects</subject><subject>Muscle, Smooth - drug effects</subject><subject>Muscle, Smooth - metabolism</subject><subject>Neurotransmitter Agents - chemistry</subject><subject>Neurotransmitter Agents - isolation & purification</subject><subject>Neurotransmitter Agents - pharmacology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Receptor, Muscarinic M3 - drug effects</subject><subject>Receptor, Muscarinic M3 - metabolism</subject><subject>Receptors, G-Protein-Coupled - drug effects</subject><subject>Receptors, G-Protein-Coupled - metabolism</subject><subject>Receptors, Histamine H1 - drug effects</subject><subject>Receptors, Histamine H1 - metabolism</subject><subject>Receptors, Serotonin, 5-HT2 - drug effects</subject><subject>Receptors, Serotonin, 5-HT2 - metabolism</subject><subject>Sesquiterpenes, Eudesmane - chemistry</subject><subject>Sesquiterpenes, Eudesmane - isolation & purification</subject><subject>Sesquiterpenes, Eudesmane - pharmacology</subject><subject>Sesquiterpenoids</subject><subject>Solvents - chemistry</subject><subject>Trachea - drug effects</subject><subject>Trachea - metabolism</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS0EoreFB2CDvEGsEvyT2IlYXVVAkSp1064txxkHX-Xaqe1U8Bo8Mb4_wK6r2Xxzzsw5CL2jpKaEik-7egdLzQilNRE1adgLtKGdZJVsJX-JNoTLrupkQy_QZUo7QoikDXmNLhiVgkkhNuj31mQXfMLB4m3MsHfJafy0zpOOLmH4maM2OWHtR-xSmHWGESdIj6vLEBfwgOcCBA-FmbTzKeMIBpYcYsJ7GJ3Ozk_YBH9UKl4Hq2l1HjRe3ITdDOv-qH8AfoB-g15ZPSd4e55X6OHrl_vrm-r27tv36-1tZXjHcqUNN0NrrWW85YwNDXDB9SDFIPkIPRHj0PZcMwOdHcSoKR962dGxt0wa3lt-hT6edJcYHldIWZXnDcyz9hDWpLqu6RpZtAtJT6SJIaUIVi3R7XX8pShRhybUTpUm1KEJRYQqTZSd92f1dSgx_Nv4G30BPpwBnYyebdTeuPSfa1rSkqP55xMHJYsnB1El48CbEm0JOqsxuGfO-ANnB6qV</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Natividad, Gaudencio M.</creator><creator>Broadley, Kenneth J.</creator><creator>Kariuki, Benson</creator><creator>Kidd, Emma J.</creator><creator>Ford, William R.</creator><creator>Simons, Claire</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20110901</creationdate><title>Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea</title><author>Natividad, Gaudencio M. ; Broadley, Kenneth J. ; Kariuki, Benson ; Kidd, Emma J. ; Ford, William R. ; Simons, Claire</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-ac3cb5fff235322b4e363ab76b73de906db593a2ce8fb6da13b9781d9f27c39f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Antihistamine</topic><topic>Artemisia - chemistry</topic><topic>Artemisia vulgaris</topic><topic>Asthma</topic><topic>Biological and medical sciences</topic><topic>Chloroform - chemistry</topic><topic>Dose-Response Relationship, Drug</topic><topic>General pharmacology</topic><topic>Guinea Pigs</topic><topic>Histamine H1 Antagonists - pharmacology</topic><topic>Ileum</topic><topic>Ileum - drug effects</topic><topic>Ileum - metabolism</topic><topic>In Vitro Techniques</topic><topic>Lactones - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Methanol - chemistry</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Relaxation - drug effects</topic><topic>Muscle, Smooth - drug effects</topic><topic>Muscle, Smooth - metabolism</topic><topic>Neurotransmitter Agents - chemistry</topic><topic>Neurotransmitter Agents - isolation & purification</topic><topic>Neurotransmitter Agents - pharmacology</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Receptor, Muscarinic M3 - drug effects</topic><topic>Receptor, Muscarinic M3 - metabolism</topic><topic>Receptors, G-Protein-Coupled - drug effects</topic><topic>Receptors, G-Protein-Coupled - metabolism</topic><topic>Receptors, Histamine H1 - drug effects</topic><topic>Receptors, Histamine H1 - metabolism</topic><topic>Receptors, Serotonin, 5-HT2 - drug effects</topic><topic>Receptors, Serotonin, 5-HT2 - metabolism</topic><topic>Sesquiterpenes, Eudesmane - chemistry</topic><topic>Sesquiterpenes, Eudesmane - isolation & purification</topic><topic>Sesquiterpenes, Eudesmane - pharmacology</topic><topic>Sesquiterpenoids</topic><topic>Solvents - chemistry</topic><topic>Trachea - drug effects</topic><topic>Trachea - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Natividad, Gaudencio M.</creatorcontrib><creatorcontrib>Broadley, Kenneth J.</creatorcontrib><creatorcontrib>Kariuki, Benson</creatorcontrib><creatorcontrib>Kidd, Emma J.</creatorcontrib><creatorcontrib>Ford, William R.</creatorcontrib><creatorcontrib>Simons, Claire</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Natividad, Gaudencio M.</au><au>Broadley, Kenneth J.</au><au>Kariuki, Benson</au><au>Kidd, Emma J.</au><au>Ford, William R.</au><au>Simons, Claire</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2011-09-01</date><risdate>2011</risdate><volume>137</volume><issue>1</issue><spage>808</spage><epage>816</epage><pages>808-816</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><coden>JOETD7</coden><abstract>The present study evaluates the Philippine medicinal plant Artemisia vulgaris for antagonistic activity at selected biogenic amine receptors on smooth muscle of the airways and gastrointestinal tract in order to explain its traditional use in asthma and hyperactive gut.
The antagonistic activity of chloroform crude extract (AV-CHCl3) and methanol crude extract (AV-MeOH) of Artemisia vulgaris was studied against concentration–response curves for contractions of the guinea pig ileum and trachea to 5-hydroxytrptamine (5-HT2 receptors), methacholine (M3 muscarinic receptors), histamine (H1 receptors) and β-phenylethylamine (trace amine-associated receptors, TAAR1).
The Artemisia vulgaris chloroform (AV-CHCl3) and methanol (AV-MeOH) extract showed histamine H1 antagonism in the ileum and trachea. Further analysis of AV-CHCl3 isolated two major components, yomogin and 1,2,3,4-diepoxy-11(13)-eudesmen-12,8-olide. Yomogin, a sesquiterpene lactone, exhibited a novel histamine H1 receptor antagonism in the ileum.
The presence of a specific, competitive histamine receptor antagonist and smooth muscle relaxant activity in Artemisia vulgaris extracts on the smooth muscle in ileum and trachea explains its traditional use in the treatment of asthma and hyperactive gut.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>21762766</pmid><doi>10.1016/j.jep.2011.06.042</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-8741 |
| ispartof | Journal of ethnopharmacology, 2011-09, Vol.137 (1), p.808-816 |
| issn | 0378-8741 1872-7573 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_884847532 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antihistamine Artemisia - chemistry Artemisia vulgaris Asthma Biological and medical sciences Chloroform - chemistry Dose-Response Relationship, Drug General pharmacology Guinea Pigs Histamine H1 Antagonists - pharmacology Ileum Ileum - drug effects Ileum - metabolism In Vitro Techniques Lactones - pharmacology Male Medical sciences Methanol - chemistry Muscle Contraction - drug effects Muscle Relaxation - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Neurotransmitter Agents - chemistry Neurotransmitter Agents - isolation & purification Neurotransmitter Agents - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plants, Medicinal Receptor, Muscarinic M3 - drug effects Receptor, Muscarinic M3 - metabolism Receptors, G-Protein-Coupled - drug effects Receptors, G-Protein-Coupled - metabolism Receptors, Histamine H1 - drug effects Receptors, Histamine H1 - metabolism Receptors, Serotonin, 5-HT2 - drug effects Receptors, Serotonin, 5-HT2 - metabolism Sesquiterpenes, Eudesmane - chemistry Sesquiterpenes, Eudesmane - isolation & purification Sesquiterpenes, Eudesmane - pharmacology Sesquiterpenoids Solvents - chemistry Trachea - drug effects Trachea - metabolism |
| title | Actions of Artemisia vulgaris extracts and isolated sesquiterpene lactones against receptors mediating contraction of guinea pig ileum and trachea |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T18%3A50%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Actions%20of%20Artemisia%20vulgaris%20extracts%20and%20isolated%20sesquiterpene%20lactones%20against%20receptors%20mediating%20contraction%20of%20guinea%20pig%20ileum%20and%20trachea&rft.jtitle=Journal%20of%20ethnopharmacology&rft.au=Natividad,%20Gaudencio%20M.&rft.date=2011-09-01&rft.volume=137&rft.issue=1&rft.spage=808&rft.epage=816&rft.pages=808-816&rft.issn=0378-8741&rft.eissn=1872-7573&rft.coden=JOETD7&rft_id=info:doi/10.1016/j.jep.2011.06.042&rft_dat=%3Cproquest_cross%3E884847532%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=884847532&rft_id=info:pmid/21762766&rft_els_id=S0378874111004715&rfr_iscdi=true |