FoxO3a Functions as a Key Integrator of Cellular Signals That Control Glioblastoma Stem‐like Cell Differentiation and Tumorigenicity

Glioblastoma is one of the most aggressive types of human cancer, with invariable and fatal recurrence even after multimodal intervention, for which cancer stem‐like cells (CSLCs) are now being held responsible. Our recent findings indicated that combinational inhibition of phosphoinositide‐3‐kinase...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2011-09, Vol.29 (9), p.1327-1337
Hauptverfasser:	Sunayama, Jun, Sato, Atsushi, Matsuda, Ken‐Ichiro, Tachibana, Ken, Watanabe, Eriko, Seino, Shizuka, Suzuki, Kaori, Narita, Yoshitaka, Shibui, Soichiro, Sakurada, Kaori, Kayama, Takamasa, Tomiyama, Arata, Kitanaka, Chifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Differentiation - physiology Extracellular signal‐regulated kinase Female Forkhead Box Protein O3 Forkhead Transcription Factors - biosynthesis Forkhead Transcription Factors - metabolism FoxO3a Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma stem cells Humans Male MAP Kinase Signaling System - drug effects Mice Mice, Inbred BALB C Mice, Nude Mitogen-Activated Protein Kinases - metabolism Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology p70S6K Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism Signal Transduction TOR Serine-Threonine Kinases - antagonists & inhibitors TOR Serine-Threonine Kinases - metabolism Tumor Cells, Cultured Up-Regulation
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