Cytotoxic activity of secondary metabolites derived from Artemisia annua L. towards cancer cells in comparison to its designated active constituent artemisinin

Artemisia annua L. (sweet wormwood, qinhao) has traditionally been used in Chinese medicine. The isolation of artemisinin from Artemisia annua and its worldwide accepted application in malaria therapy is one of the showcase success stories of phytomedicine during the past decades. Artemisinin-type c...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2011-08, Vol.18 (11), p.959-969
Hauptverfasser:	Efferth, Thomas, Herrmann, Florian, Tahrani, Ahmed, Wink, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - pharmacology Artemisia annua Artemisia annua - chemistry Artemisinin Artemisinins - pharmacology Cancer Cyclohexanols - pharmacology Dose-Response Relationship, Drug Drug resistance Drug Resistance, Neoplasm Drug Screening Assays, Antitumor - methods HeLa Cells - drug effects Humans Microarray Molecular Structure Monoterpenes - pharmacology Natural products Oligonucleotide Array Sequence Analysis Parasitic Sensitivity Tests - methods Pharmacogenomics Plant Extracts - chemistry Plant Extracts - pharmacology Scopoletin - pharmacology Trypanocidal Agents - pharmacology Trypanosoma Trypanosoma brucei brucei - cytology Trypanosoma brucei brucei - drug effects
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